clobetasol and Warts

The effects of topical indomethacin and clobetasol propionate on erythema and oedema following low-dose cryotherapy to normal skin were examined using a single-blind technique. Both agents significantly reduced erythema, but neither had a significant effect on oedema. A further, controlled, double-blind study comparing topical indomethacin and inert gel base was performed after cryotherapy to hand warts. In this study, topical indomethacin had no significant effect on post-cryotherapy oedema, erythema, pain or blister formation 48 and 96 h after treatment. Both potent topical steroids and cyclo-oxygenase inhibitors reduce erythema after low-dose cryotherapy. In clinical practice, there is no evidence that topical indomethacin significantly inhibits the inflammatory response to cryotherapy.

Topics: Administration, Topical; Adolescent; Adult; Child; Clobetasol; Cryotherapy; Dermatitis; Double-Blind Method; Edema; Erythema; Female; Humans; Indomethacin; Male; Middle Aged; Postoperative Complications; Skinfold Thickness; Warts

A double-blind, randomized, placebo-controlled trial was carried out comparing the effects of clobetasol propionate ointment and the ointment base on the inflammation induced by cryotherapy of basal cell carcinomata and warts. A single application of the steroid was shown to be significantly better at reducing erythema, pain and swelling than the ointment base.

Topics: Adolescent; Adult; Aged; Betamethasone; Carcinoma, Basal Cell; Clinical Trials as Topic; Clobetasol; Cryosurgery; Dermatitis; Double-Blind Method; Erythema; Humans; Middle Aged; Ointments; Skin Diseases; Skin Neoplasms; Warts

Topics: Administration, Topical; Anti-Inflammatory Agents; Clobetasol; Diagnosis, Differential; Follow-Up Studies; Glucocorticoids; Humans; Infant; Male; Psoriasis; Warts