clobetasol and Porokeratosis

Porokeratosis is a disorder of clonal hyperproliferation of keratinocytes with several different clinical manifestations. Cutaneous lesions vary in their appearance and distribution. All variants share the distinguishing cornoid lamella on histopathological examination. We present an unusual case of disseminated porokeratosis of Mibelli in an immunocompetent patient.

Topics: Abdomen; Aged; Arm; Biopsy; Buttocks; Clobetasol; Dermatologic Agents; Groin; Humans; Immunocompetence; Leg; Male; Organ Specificity; Porokeratosis; Pruritus

Topics: Aged; Biopsy; Clobetasol; Dermatologic Agents; Glucocorticoids; Humans; Male; Nicotinic Acids; Porokeratosis; Scalp; Treatment Failure

[corrected] Prorokeratosis of Mibelli is a chronic disorder characterised by slightly atrophic plaques surrounded by keratotic border.. A 45-year-old with clobetazole propionate ointment for psoriasis over 15 years developed characteristic lesions of porokeratosis Mibelli on the elbows. Histopathological examination revealed the cornoid lamellae located on the edges of the specimen and psoriasiform acanthosis and a spongiotic pustule formation in the center of the specimen; thus, it was suggested as 'psoriasis encircled by porokeratosis'.. Development of porokeratosis may be explained by the local immunosuppressive effect of the prolonged application of the topical steroid.

Topics: Acanthosis Nigricans; Catheter Ablation; Clobetasol; Glucocorticoids; Humans; Immunocompromised Host; Male; Middle Aged; Porokeratosis; Psoriasis; Treatment Outcome