clobetasol and Ovarian-Neoplasms

A massive extravasation of pegylated-liposomal doxorubicin (Doxil) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.

Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Antibiotics, Antineoplastic; Clobetasol; Doxorubicin; Edema; Erythema; Extravasation of Diagnostic and Therapeutic Materials; Female; Forearm; Glucocorticoids; Humans; Hypothermia, Induced; Infusions, Intravenous; Injections, Subcutaneous; Middle Aged; Ovarian Neoplasms; Polyethylene Glycols; Treatment Outcome