clobetasol and Lip-Diseases

Lichen sclerosus et atrophicus is a depigmenting mucocutaneous disease most frequently affecting the female genitalia. Genital lesions are symptomatic and may be functionally debilitating. Oral lesions are of little significance other than the esthetic concerns of perioral lesions. In view of the rarity of reported cases, one lesion of the labial mucocutaneous area and a second of the palate are presented along with a description of the disease's clinical and histopathologic findings and a brief review of the literature. The lip lesion was partially resolved with topical corticosteroids and was then fully eliminated with topical testosterone. Histologic verification and examination for the simultaneous occurrence or absence of oral and the more common genital-cutaneous lesions is essential if meaningful information in the medical-dental literature is to be obtained in the future.

Topics: Administration, Topical; Adolescent; Anti-Inflammatory Agents; Antineoplastic Agents, Hormonal; Clobetasol; Diagnosis, Differential; Glucocorticoids; Humans; Lichen Planus, Oral; Lichen Sclerosus et Atrophicus; Lip Diseases; Male; Mouth Diseases; Palate, Soft; Testosterone

The objective of the present study was to compare a new type of symptomatic lichenoid reaction, specifically located on the mucosal side of the lips, and associated with microorganisms, with a matched group presenting with reticular oral lichen planus (OLP) of the buccal mucosa.. The mean age for both groups was 66 years with a predominance of women (62%). The lichenoid reaction group (n = 25) presented with a reticular reaction pattern embracing various degrees of erythema. Patients presenting with OLP had similar lesions confined to the buccal mucosa but not on the mucosal side of the lips.. In both groups, 80% were on any type of medication. However, 56% of the patients with lichenoid reactions medicated with more than three drugs compared with 29% (P < 0.05) in the OLP group. The former group more often used medicaments prescribed for cardiovascular diseases (48%vs 25%). Twenty-two of the patients with lichenoid reactions were treated with chlorhexidine. In 80% of these patients (n = 18), the lesions improved or completely healed, indicating a microbial association.. Lichenoid reactions present on the mucosal side of the lips may be initiated by microbial plaque precipitated on the buccal surfaces of the anterior teeth.

Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Cardiovascular Agents; Case-Control Studies; Chlorhexidine; Clobetasol; Composite Resins; Dental Calculus; Dental Restoration, Permanent; Erythema; Female; Glucocorticoids; Humans; Lichen Planus, Oral; Lichenoid Eruptions; Lip Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors

Lichen planus with simultaneous oral and genital involvement in males is a quite rare condition and often difficult to diagnose. The prevalence, treatment options, and management for this condition are far from being established, and research in this area primarily relies on anecdotes. We present the clinical features of eight cases of peno-gingival lichen planus and propose a management algorithm for this condition based on the best available published evidence.. Personal medical history was collected for all cases. Following careful examination of the oral and genital mucosae, pathology was obtained, previous treatments and duration of mucosal lesions ascertained, treatment initiated, and response evaluated at 8 weeks on both oral and genital lesions. The first-line drug was topical clobetasol propionate 0.05% cream in all cases; in case of failure, topical cyclosporin was used. A review of the literature on treatment options for this rare condition was performed based upon standard literature review practices.. Five cases presented gingival lesions that clinically resembled lichen planus. Glans penis was involved in all patients. All patients responded to treatment except for one. Oral candidiasis was the only observed side effect.. Genital lichen planus may be suspected in males when atrophic-erosive gingival lichen planus is found. A thorough multidisciplinary medical management and active early treatment are necessary to improve symptoms and prevent genital sequelae and, given the risk of squamous cell carcinoma, as a preventative strategy, although this area still needs investigation. Therapeutic trials relating to the treatment of peno-gingival lichen planus may be undertaken considering that current management relies exclusively on observations of case reports.

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Candidiasis, Oral; Cheek; Clobetasol; Cohort Studies; Follow-Up Studies; Gingival Diseases; Glucocorticoids; Humans; Lichen Planus; Lichen Planus, Oral; Lip Diseases; Male; Medical History Taking; Middle Aged; Penile Diseases; Remission Induction; Tongue Diseases; Treatment Outcome

A case of plasma cell mucositis is described for its rarity. A probable aetiological correlation with periodontitis is discussed. The patient showed good response to intralesional and topical steroids.

Topics: Clobetasol; Drug Therapy, Combination; Follow-Up Studies; Gingivitis; Humans; Injections, Intralesional; Lip Diseases; Male; Middle Aged; Mouth Mucosa; Plasma Cells; Treatment Outcome; Triamcinolone

Topics: Administration, Topical; Betamethasone; Clobetasol; Female; Humans; Lip Diseases; Middle Aged; Plasma Cells