clobetasol and Keratosis

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Breast Diseases; Clobetasol; Female; Glucocorticoids; Humans; Keratosis; Middle Aged; Mometasone Furoate; Nipples; Ointments; Pregnadienediols; Vasoconstrictor Agents

Topics: Administration, Topical; Clobetasol; Desmoglein 3; Exanthema; Female; Fluorescent Antibody Technique; Glucocorticoids; Humans; Injections, Intralesional; Keratosis; Middle Aged; Pemphigus; Scalp; Skin Diseases; Treatment Outcome; Triamcinolone

Topics: Abdomen; Amoxicillin-Potassium Clavulanate Combination; Anti-Inflammatory Agents; Benzimidazoles; Carnitine; Clobetasol; Dermatitis; Edema; Erythema; Female; Humans; Injections, Subcutaneous; Keratosis; Lipolysis; Mesotherapy; Middle Aged; Peptides; Phosphatidylcholines; Piperidines; Prednisone; Subcutaneous Fat; Thigh

Bevacizumab is a recombinant humanized antibody against vascular endothelial growth factor (VEGF). It is approved by the Food and Drug Administration (FDA) for metastatic colorectal cancer, advanced non-small cell lung cancer, metastatic renal cell cancer and glioblastoma. Bevacizumab has also been used off label in ophthalmology for age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, retinopathy of prematurity, and other chorioretinal vascular disorders. Numerous case reports have described various cutaneous reactions in response to bevacizumab therapy including acneiform eruptions and exfoliative dermatitis.. We report a case of a 63 year-old Caucasian female who presented with subacute cutaneous lupus erythematosus six weeks after initiating two intravitreal injections of bevacizumab for central serous choroidopathy.. We report the first documented case of a cutaneous lupus erythematosus eruption following bevacizumab administration as a monotherapy.

Topics: Administration, Topical; Angiogenesis Inhibitors; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Choroid Diseases; Clobetasol; Female; Humans; Injections; Keratosis; Lupus Erythematosus, Cutaneous; Middle Aged; Off-Label Use; Scalp; Skin; Vitreous Body

A 45-year-old white woman presented with several years' history of firm, shiny papules on the lateral hands with slight extension to the dorsal fingers. The lesions first appeared between the index fingers and thumbs on both hands. They gradually increased in number, coalescing into plaques and affecting the junction between the palmar and dorsal skin. The patient did not have involvement of her feet. She had been diagnosed previously with chronic eczema that had failed to respond to multiple topical medications. In addition, the patient's sister had similar lesions on both hands. The patient denied any symptoms of hyperhidrosis, excessive sun exposure, or trauma. The plaques were asymptomatic, but were cosmetically unappealing to the patient. On physical examination, small, firm, skin-colored, hyperkeratotic papules, coalescing into plaques, were located on the junction between the palmar and dorsal skin on both lateral margins of the thumb and on the radial side of the index finger (Fig. 1). There were no lesions on the feet. A biopsy taken from a papule on the patient's left hand was consistent histologically with acrokeratoelastoidosis. The biopsy showed marked degeneration of collagen in the dermis with solar elastosis and some smudging of the papillary dermal collagen (Fig. 2). She was treated with clobetasone cream to the affected areas on the hands. After 6 weeks of treatment, she reported no significant improvement.

Topics: Clobetasol; Elastic Tissue; Female; Glucocorticoids; Hand Dermatoses; Humans; Keratosis; Middle Aged; Skin Diseases, Genetic; Treatment Failure

Atrophic plaques with white borders are occasionally seen on sun-exposed areas of the skin. These patients are usually elderly and have solar elastosis. This condition is referred to as annular atrophic plaques of skin and we describe a typical case.

Topics: Aged; Atrophy; Biopsy; Chronic Disease; Clobetasol; Diagnosis, Differential; Epidermis; Humans; Keratosis; Male; Sclerosis; Skin Diseases