clobetasol and Hypoxia

clobetasol has been researched along with Hypoxia* in 1 studies

Other Studies

1 other study(ies) available for clobetasol and Hypoxia

Article	Year
The effect of topical steroids on cutaneous oxygen tension. The British journal of dermatology, 1992, Volume: 126, Issue:5 The precise mode of action of topically applied steroids is unknown. We have applied clobetasol propionate 0.05% ointment (Dermovate; Glaxo Pharmaceuticals) under occlusion to the forearm skin of 10 healthy volunteers for 6 h and monitored transcutaneous oxygen tension at the site for 19 h after its removal. Compared to the ointment base, the steroid-treated area was significantly hypoxic up to 13 h after application. The profound hypoxia present at the site of application of clobetasol propionate 0.05% ointment may account for some of its anti-inflammatory effects, and its atrophogenicity. Topics: Administration, Topical; Blood Gas Monitoring, Transcutaneous; Clobetasol; Humans; Hypoxia; Regional Blood Flow; Skin	1992

Article

Year

The effect of topical steroids on cutaneous oxygen tension.

The British journal of dermatology, 1992, Volume: 126, Issue:5

The precise mode of action of topically applied steroids is unknown. We have applied clobetasol propionate 0.05% ointment (Dermovate; Glaxo Pharmaceuticals) under occlusion to the forearm skin of 10 healthy volunteers for 6 h and monitored transcutaneous oxygen tension at the site for 19 h after its removal. Compared to the ointment base, the steroid-treated area was significantly hypoxic up to 13 h after application. The profound hypoxia present at the site of application of clobetasol propionate 0.05% ointment may account for some of its anti-inflammatory effects, and its atrophogenicity.

Topics: Administration, Topical; Blood Gas Monitoring, Transcutaneous; Clobetasol; Humans; Hypoxia; Regional Blood Flow; Skin

1992