clobetasol and Hypertrophy

Twenty-three patients with resistant psoriasis vulgaris were evaluated clinically and histologically before and after treatment with potent topically administered steroids. It was shown that psoriatic plaques are comprised of clinically and histologically distinct acute and chronic areas, each responding differently to treatment. Chronic areas, characterized by chronic inflammation, respond well to therapy; acute areas, characterized by acute inflammation, are resistant to therapy. It is suggested that the psoriagenic stimulus is greater within the therapy-resistant "hot spots." Future therapy aimed at hot spots may aid in the better control of psoriasis.

Topics: Administration, Topical; Betamethasone; Biopsy; Clobetasol; Drug Resistance; Humans; Hypertrophy; Psoriasis; Steroids; Triamcinolone

Verrucous or hypertrophic lichen planus is a chronic inflammatory skin disease characterized by extremely pruritic thick hyperkeratotic plaques and is resistant to topical treatment.. Herein, we report three clinical cases of hypertrophic lichen planus successfully treated with a combination of topical steroids daily in occlusion and trichloroacetic acid (TCA) 50% with peeling every week.. TCA is involved in regulating inflammation and scarring. Through its keratolytic properties it enhances the efficacy of topical steroids, whose action is hindered by hyperkeratosis.. The combination of TCA and topical steroids offers a good alternative for the treatment of hypertrophic lichen planus.

Topics: Aged, 80 and over; Anti-Inflammatory Agents; Clobetasol; Drug Therapy, Combination; Female; Humans; Hypertrophy; Keratolytic Agents; Lichen Planus; Male; Middle Aged; Pruritus; Trichloroacetic Acid

Topics: Administration, Topical; Clobetasol; Combined Modality Therapy; Glucocorticoids; Humans; Hypertrophy; Lasers, Gas; Lichen Planus; Skin