clobetasol and Granuloma

There is a lack of evidence on the best treatment option for umbilical granuloma. The primary aim of this study was to compare three treatments for umbilical granuloma: standard treatment with topical silver nitrate, clobetasol propionate cream (0.05%) and ethanol wipes. The secondary aim was to evaluate whether the treatment could be successfully administered by a parent at home, rather than in the outpatient clinic.. A total of 109 infants were randomised to one of three groups and 94 infants completed the assigned treatment: 30 infants received standard treatment with silver nitrate (99%) in the outpatient clinic, 30 infants had topical clobetasol propionate cream (0.05%) applied at home, and 34 infants received cleansing with ethanol wipes (82%) at home.. Silver nitrate and clobetasol propionate cream (0.05%) were significantly superior to ethanol wipes, with shorter healing times and higher resolution rates (p = 0.0001). Healing time and resolution rates were identical for silver nitrate and clobetasol propionate cream (0.05%). Mild side effects were occasionally reported, all of which were self-limiting.. Treating umbilical granuloma with topical clobetasol propionate cream (0.05%) at home is as effective as treating it with topical silver nitrate (99%) in the clinic.

Topics: Administration, Topical; Anti-Infective Agents, Local; Clobetasol; Ethanol; Female; Glucocorticoids; Granuloma; Humans; Infant; Male; Silver Nitrate; Skin Diseases; Umbilical Cord

Granuloma inframammary adultorum represents a variant of erosive papulonodular dermatosis; we report a case of a patient with bilateral erosive plaques and nodules predominantly located under the breast.

Topics: Administration, Cutaneous; Breast; Clobetasol; Dermoscopy; Female; Glucocorticoids; Granuloma; Humans; Middle Aged; Skin Diseases

Topics: Adult; Anticonvulsants; Clobetasol; Dermatitis; Drug Eruptions; Eating; Female; Glucocorticoids; Granuloma; Humans; Migraine Disorders; Skin; Skin Diseases; Topiramate; Treatment Outcome

Foreign body gingivitis (FBG) is a non-plaque induced chronic inflammatory process involving the marginal and/or attached gingiva. It results from the introduction of foreign particulate material, primarily dental prophylaxis paste and restorative dental materials, into the gingival tissues. Clinical presentation varies from an erythematous to vesiculoerosive-like process that may mimic a localized form of desquamative gingivitis or an erosive lichenoid process. Rarely, it may also present with a granular appearance. We describe the clinical presentation, differential diagnosis and clinical management of a 52-year-old Woman who presented with localized chronic inflammation of the maxillary anterior and left posterior gingiva secondary to the presence of foreign material.

Topics: Anti-Inflammatory Agents; Biopsy; Clobetasol; Diagnosis, Differential; Female; Foreign-Body Reaction; Gingival Diseases; Gingival Hyperplasia; Gingivitis; Glucocorticoids; Granuloma; Humans; Middle Aged

A well appearing 73-year-old Caucasian lady presented with a long-standing history of yellowish atrophic lesions on her limbs and trunk. The lesions were asymptomatic. These were found to be consistent with the diagnosis of Necrobiotic Xanthogranuloma (NXG) on histology. The reported patient did not have the characteristic skin changes and instead had unusual lesions reminiscent of morphoea not described in the literature. She reported no associated systemic symptoms.

Topics: Aged; Anti-Inflammatory Agents; Clobetasol; Female; Glucocorticoids; Granuloma; Humans; Necrobiotic Disorders; Paraproteinemias; Xanthomatosis

Tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of numerous inflammatory conditions, possibly facilitating the induction and maintenance of these diseases through lymphocyte activation and cytokine production. Inhibitors of TNF-alpha have proven efficacious in the treatment of autoimmune diseases such as psoriasis, rheumatoid arthritis, inflammatory bowel disease, and lymphoproliferative disorders. However, recent cases of adverse cutaneous reactions have been reported in anti-TNF-alpha therapy, most notably those of granulomatous morphology. We report a patient with rheumatoid arthritis who had been treated with etanercept (50 mg/wk) for 6.5 years. The patient subsequently developed pink and red papules on large areas of the upper and lower extremities. Skin biopsy specimens revealed both poorly formed and well-circumscribed nonnecrotizing epithelioid granulomas in the superficial dermis. Application of clobetasol propionate ointment 0.05% without discontinuation of anti-TNF-alpha therapy led to complete resolution of the skin lesions. While the precise mechanisms of physiologic and pathologic TNF activity remain to be determined, it is clear that granulomatous lesions may emerge as a complication of anti-TNF-alpha therapy. Treatment with topical corticosteroids may be sufficient to eliminate such lesions.

Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Clobetasol; Drug Eruptions; Etanercept; Female; Granuloma; Humans; Immunoglobulin G; Middle Aged; Receptors, Tumor Necrosis Factor

Orofacial granulomatosis (OFG) is a descriptive term used for granulomatous disorders of the face and oral cavity that may occur for a variety of reasons, some of which result in significant morbidity and mortality. Although rarely, a granular enlargements of the gingiva may be the first clinical manifestation of OFG, preceding other local or systemic manifestations.. We will report a case of OFG that showed an atypical and monosymptomatic onset with a generalized hyperplastic gingivitis that preceded other facial and mucosal features by several weeks.. Considering the variable clinical onset of OFG and its apparent increase in incidence, we emphasize that in some cases, the periodontologist, as first consulted health care professional, plays an important role to detect this disorder. Early diagnosis of OFG is a crucial step to prevent and cure its unsightly sequelae and sometimes avoid progression of systemic potentially life-threatening OFG-related diseases.. Thus, when none of the common causes of gingival enlargement can be detected, OFG diagnosis should be suspected.

Topics: Adult; Anti-Inflammatory Agents; Cheilitis; Clobetasol; Diagnosis, Differential; Disease Progression; Edema; Face; Female; Giant Cells; Gingival Hyperplasia; Glucocorticoids; Granuloma; Humans; Mouth Diseases; Triamcinolone

Actinic granuloma of O'Brien and giant molluscum contagiosum in immunocompetent adults are rare skin disorders. There have been no previous reports of these two conditions occurring together. We report this occurrence in a 57-year-old Caucasian woman.

Topics: Administration, Topical; Anti-Inflammatory Agents; Cautery; Clobetasol; Female; Forehead; Glucocorticoids; Granuloma; Humans; Middle Aged; Molluscum Contagiosum; Neck; Photosensitivity Disorders

Topics: Administration, Topical; Anti-Inflammatory Agents; Clobetasol; Glucocorticoids; Granuloma; Humans

The treatment of granuloma annulare is still unsatisfactory. A number of topical and systemic therapies have been tried, some of which can improve the condition, but serious side effects are possible with those reported so far. We treated a patient with disseminated granuloma annulare by local application of a vitamin E emulsion and achieved a marked improvement within as little as 12 days.

Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Breast Neoplasms; Clobetasol; Drug Therapy, Combination; Female; Granuloma; Humans; Paraneoplastic Syndromes; Skin Diseases; Vitamin E