clobetasol and Granuloma-Annulare

We present further evidence that granuloma annulare and autoimmune thyroiditis may be associated. Only 11 cases have been previously reported with this association as far as we know. It may be advantageous to consider checking the thyroid-stimulating hormone and/or antithyroid antibodies before administering medications that could affect thyroid function in patients with granuloma annulare.

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Clobetasol; Female; Glucocorticoids; Granuloma Annulare; Humans; Thyroiditis, Autoimmune

The association of malignant lymphomas with non-necrotic epithelioid granulomas has been reported rarely since 1977. Hodgkin's disease-associated widespread cutaneous granuloma annulare (GA) has been reported in only eight patients. We report the second case of subcutaneous GA associated with Hodgkin's disease. A 73-year-old man with Epstein-Barr virus-associated Hodgkin's lymphoma and paraneoplastic subcutaneous GA, presented 3 months after the diagnosis of malignancy. Examination revealed a large, broad erythematous, indurated, subcutaneous plaque spanning the majority of the left lower back and flank with no associated symptoms. Initial biopsy was suggestive of morphea. Prompted by positron emission tomography (PET) findings of increased fluorodeoxyglucose (FDG) uptake, a second, deeper biopsy was performed, revealing subcutaneous palisaded granulomatous dermatitis. After complete workup, the diagnosis most strongly suggested subcutaneous GA. This case highlights the importance of deep incisional biopsies, the fluorodeoxyglucose - positron emission tomography (FDG-PET) findings in GA and the rare association of GA with Hodgkin's disease which may signal the presence of malignancy.

Topics: Aged; Anti-Inflammatory Agents; Back; Clobetasol; Diagnosis, Differential; Drug Therapy, Combination; Fluorodeoxyglucose F18; Granuloma Annulare; Hodgkin Disease; Humans; Male; Paraneoplastic Syndromes; Positron-Emission Tomography; Triamcinolone

Topics: Administration, Topical; Bone Plates; Clobetasol; Device Removal; Diagnosis, Differential; Fracture Fixation, Intramedullary; Glucocorticoids; Granuloma Annulare; Hand; Humans; Male; Middle Aged; Radius Fractures; Skin; Treatment Outcome

Topics: Adult; Clobetasol; Coloring Agents; Glucocorticoids; Granuloma Annulare; Humans; Hydrocortisone; Leg; Male; Tattooing

Topics: Aged, 80 and over; Anti-Inflammatory Agents; Clobetasol; Female; Granuloma Annulare; Humans; Hypercalcemia; Hyperparathyroidism; Models, Biological

A case of granuloma annulare that developed in a site of healed herpes zoster is reported. Polymerase chain reaction failed to detect VZV DNA in a biopsy specimen. The occurrence of different types of cutaneous reactions in a body area previously affected by herpes virus infection is known as Wolf's isotopic response. Pathogenesis may be due to a local neuroimmune dysregulation set off by herpesvirus-induced lesions of dermal sensory nerve fibres.

Topics: Antiviral Agents; Biopsy, Needle; Clobetasol; Drug Therapy, Combination; Female; Follow-Up Studies; Granuloma Annulare; Herpes Zoster; Humans; Immunohistochemistry; Middle Aged; Pentoxifylline; Risk Assessment; Scapula; Treatment Outcome