clobetasol and Genital-Diseases--Female

To observe the clinical effects of short-term application of ultrapotent topical corticosteroid on symptomatic genital lesions of lichen sclerosus in pediatric patients.. Case series of 10 prepubertal girls with genital lichen sclerosus. Ultrapotent topical corticosteroids were applied twice daily for 6 to 8 weeks and patients were reexamined at completion of treatment. Long-term follow-up over 6 months to 3 years.. Pediatric dermatology clinic (referral center).. Ten prepubertal girls with typical clinical features of genital and/or perianal lichen sclerosus.. Topical ultrapotent corticosteroid ointment was applied sparingly to affected areas for 6 to 8 weeks.. Improvement of erythema, whitening erosions, and atrophy. Subjective improvement of symptoms.. All patients showed partial or total subsistence of signs and symptoms of lichen sclerosus. Frequency and severity of recurrences varied, but patients responded within a few days to reapplication of ultrapotent topical corticosteroid. No significant adverse effects were noted after the initial 6- to 8-week course of therapy or during the 6-month to 3-year follow-up period.. A 6- to 8-week course of ultrapotent topical corticosteroid is a safe and effective treatment for genital lichen sclerosus in pediatric patients.

Topics: Administration, Topical; Anti-Inflammatory Agents; Betamethasone; Child; Child, Preschool; Clobetasol; Female; Follow-Up Studies; Genital Diseases, Female; Glucocorticoids; Humans; Lichen Sclerosus et Atrophicus

Topics: Child, Preschool; Clobetasol; Diagnosis, Differential; Female; Genital Diseases, Female; Glucocorticoids; Humans; Lichen Sclerosus et Atrophicus; Ointments; Triamcinolone

Topics: Anesthetics, Local; Anti-Inflammatory Agents; Child; Clobetasol; Diagnosis, Differential; Female; Fever; Genital Diseases, Female; Genitalia, Female; Humans; Lidocaine; Pain; Ulcer