clobetasol and Folliculitis

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Clobetasol; Crystallization; Female; Folliculitis; Glucocorticoids; Herpes Zoster; Humans; Immune Checkpoint Inhibitors; Kidney Neoplasms; Male; Middle Aged; Necrosis; Neuralgia; Nivolumab; Skin; Treatment Outcome; Young Adult

Primary cicatricial alopecia (PCA) is a dermatological challenge. Because no large-scale epidemiological study regarding PCA is available yet, we investigated the National Health Insurance Service-National Sample Cohort for patients diagnosed with PCA. The annual and overall rates of incidence and prevalence of PCA during the study period (2004-2013) were estimated. Distribution of PCA subtypes, disease co-occurrence rates and frequently prescribed medications were also evaluated. The overall incidence was 6.10 (95% confidence interval [CI], 5.62-6.60) per 100 000 person-years. The incidence rate was stable over time (risk ratio [RR] = 1.012, P = 0.201) and lower in female patients (RR = 0.718, P < 0.001). The overall prevalence was 20.93 (95% CI, 17.97-23.86) per 100 000 persons. The average duration of PCA was calculated as 3.23 years. Approximately 70% of the patients were below the age of 45 years. Folliculitis decalvans and dissecting cellulitis were the most common subtypes of PCA. Logistic regression analysis showed that PCA was significantly associated with thyroid disorders (adjusted odds ratio = 1.64, P < 0.001). Clobetasol was the most frequently prescribed topical agent. Corticosteroids were the most common oral agents used, followed by tetracycline antibiotics. Our study is the first large-scale study reporting the epidemiology of PCA. We found a preponderance of males and neutrophil-associated subtypes of PCA, and PCA was related to thyroid disorders.

Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Age Distribution; Alopecia; Anti-Bacterial Agents; Asian People; Cellulitis; Child; Child, Preschool; Cicatrix; Clobetasol; Female; Folliculitis; Glucocorticoids; Humans; Incidence; Infant; Infant, Newborn; Male; Middle Aged; Prevalence; Republic of Korea; Retrospective Studies; Risk Factors; Sex Distribution; Skin; Young Adult

The fact that this patient's rash was limited to his chest provided an important diagnostic clue.

Topics: Acantholysis; Acneiform Eruptions; Administration, Oral; Administration, Topical; Biopsy; Clobetasol; Dermatitis, Seborrheic; Dermatologic Agents; Diagnosis, Differential; Drug Eruptions; Folliculitis; Histamine Antagonists; Humans; Ichthyosis; Male; Middle Aged; Skin; Terfenadine; Treatment Outcome

Topics: Alopecia; Anti-Bacterial Agents; Anti-Inflammatory Agents; Clobetasol; Diagnosis, Differential; Doxycycline; Folliculitis; Humans; Male; Scalp Dermatoses; Treatment Outcome; Young Adult

A chronic pruriginous eruption of eosinophil-rich follicular papules and pustules is observed in AIDS patients. The pathogenesis of this disease, termed eosinophil folliculitis, is poorly understood and treatment is debated.. A 30-year-old woman with AIDS developed highly pruriginous lesions of 5 month duration localized on the face, the trunk and upper limbs. There were papulo-pustules and excoriated papules. The elementary lesion was a follicular pustula. The eosinophil count was normal. The pathology examination revealed a rich eosinophil infiltration around the hair follicles and sebaceous glands as well as follicular spongiosis. Search for demodex, pityrosporons and a large number of infectious agents was negative. Oral minocyclin was uneffective. Local high-dose corticosteroids produced a remarkable effect and led to complete remission in 9 months.. Most cases of eosinophil folliculitis associated with AIDS have been reported in men, but rarely in Europe. The remarkable efficacy of the local corticosteroid in this case was exceptional. This condition could result from inappropriate inflammatory reaction in AIDS induced by various factors including demodex and pityrosporon. Several therapeutic approaches have been proposed to eradicate the triggering factors and others to modify the immune response. The exceptional response to the short local treatment with corticosteroids would suggest that this approach could be proposed as first intention treatment in eosinophil folliculitis associated with AIDS.

Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Adult; Animals; Anti-Inflammatory Agents; Back; Betamethasone; Clobetasol; Drug Therapy, Combination; Eosinophilia; Facial Dermatoses; Female; Folliculitis; Glucocorticoids; Humans; Treatment Outcome