clobetasol and Facial-Dermatoses

Ingenol mebutate (IngMeb) is approved for treatment of actinic keratoses (AK) and may cause unpredictable local skin responses (LSR).. We sought to investigate whether IngMeb-induced LSR, pain, and pruritus could be alleviated with a topical glucocorticoid and, further, to assess efficacy, cosmetic outcome, and patient satisfaction in patients with severe photodamage.. In this blinded, randomized controlled clinical trial, patients with multiple AK and field cancerization of the face or scalp were treated in 2 areas with IngMeb (0.015%) daily for 3 days. After finalized IngMeb treatment, 1 area was randomized to receive topical clobetasol propionate (0.05%) twice daily for 4 days. Assessments included LSR (0-24; days 1, 4, 8, 15, 57), pain (0-10) and pruritus (0-3; days 1-15), AK clearance (days 15, 57), and cosmetic outcome (0-3; day 57).. Clobetasol propionate application had no influence on LSR (P = .939), pain (P = .500), pruritus (P = .312), or AK cure rate (P = .991). Overall, IngMeb cleared 86% of all AK lesions, exerting a therapeutic effect on all AK severity grades; cure rates were 88%, 70%, and 60% for grade I, II, and III AK, respectively. Skin texture improved significantly in remedied areas (2.0 vs 1.0; P < .001); no hypopigmentation, hyperpigmentation, or scarring were observed.. These results do not provide safety and efficacy beyond 2 months of follow-up.. Application of clobetasol propionate does not alleviate IngMeb-induced LSR after 3 days of IngMeb treatment.

Topics: Administration, Topical; Adrenal Cortex Hormones; Aged; Aged, 80 and over; Clobetasol; Denmark; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Facial Dermatoses; Female; Follow-Up Studies; Gels; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; Pruritus; Risk Assessment; Scalp Dermatoses; Severity of Illness Index; Single-Blind Method; Treatment Outcome

Photodynamic therapy (PDT) is an effective and established treatment for actinic keratoses (AK) and nonmelanoma skin cancer. The main side-effects of PDT are post-treatment erythema and oedema, and pain during illumination. Severe erythema after PDT enhances the down time associated with the treatment.. To evaluate in a randomized intraindividual study whether use of a topical corticosteroid just before and just after PDT would reduce treatment-induced erythema compared with conventional PDT.. Twenty-two patients with multiple AKs in the face and scalp were treated with methyl aminolaevulinate PDT in two symmetrical areas. One area was randomized to superpotent corticosteroid (clobetasol propionate) before and just after PDT. Objective and visual erythema, protoporphyrin IX (PpIX) fluorescence and pain were evaluated.. Topical corticosteroid significantly reduced PDT-induced erythema (P = 0·012). The complete lesion response rate 3 months after PDT, and PpIX fluorescence prior to illumination did not differ significantly between the two treated areas.. Superpotent corticosteroid before and just after PDT reduced the erythema 24 h after treatment of multiple AKs on the face and scalp. The use of topical corticosteroid did not affect the efficacy of PDT and may be an easy way to make PDT treatment of large visible areas more acceptable.

Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents; Clobetasol; Erythema; Facial Dermatoses; Female; Fluoroscopy; Glucocorticoids; Humans; Keratosis, Actinic; Male; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp Dermatoses; Treatment Outcome

Topics: Adult; Clobetasol; Double-Blind Method; Facial Dermatoses; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Cutaneous; Male; Ointments; Tacrolimus; Treatment Outcome

Topics: Alopecia; Clobetasol; Eyebrows; Facial Dermatoses; Female; Glucocorticoids; Hair Follicle; Humans; Hydroxychloroquine; Middle Aged; Treatment Outcome

Topics: Clobetasol; Cranial Sinuses; Cushing Syndrome; Facial Dermatoses; Glucocorticoids; Humans; Jugular Veins; Magnetic Resonance Imaging; Male; Phlebography; Sinus Thrombosis, Intracranial; Tomography, X-Ray Computed; Young Adult

Topics: Clobetasol; Facial Dermatoses; Female; Glucocorticoids; Humans; Keratosis, Actinic; Male; Scalp Dermatoses

Injections of bovine collagen are a common procedure for correction of folds in the face. However, this therapy is not free from side effects. We present a patient in whom a granulomatous inflammation occurred following implantation of this material. We therefore now insist on an observation interval of 4 weeks between test injection and actual treatment, as is recommended by the manufacturer.

Topics: Absorbable Implants; Administration, Topical; Animals; Anti-Inflammatory Agents; Biocompatible Materials; Cattle; Clobetasol; Collagen; Facial Dermatoses; Female; Glucocorticoids; Granuloma, Foreign-Body; Humans; Hypersensitivity, Delayed; Injections, Subcutaneous; Middle Aged; Skin Aging

Topics: Administration, Topical; Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Cetirizine; Clobetasol; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Immunoglobulins, Intravenous; Vasculitis, Leukocytoclastic, Cutaneous

A chronic pruriginous eruption of eosinophil-rich follicular papules and pustules is observed in AIDS patients. The pathogenesis of this disease, termed eosinophil folliculitis, is poorly understood and treatment is debated.. A 30-year-old woman with AIDS developed highly pruriginous lesions of 5 month duration localized on the face, the trunk and upper limbs. There were papulo-pustules and excoriated papules. The elementary lesion was a follicular pustula. The eosinophil count was normal. The pathology examination revealed a rich eosinophil infiltration around the hair follicles and sebaceous glands as well as follicular spongiosis. Search for demodex, pityrosporons and a large number of infectious agents was negative. Oral minocyclin was uneffective. Local high-dose corticosteroids produced a remarkable effect and led to complete remission in 9 months.. Most cases of eosinophil folliculitis associated with AIDS have been reported in men, but rarely in Europe. The remarkable efficacy of the local corticosteroid in this case was exceptional. This condition could result from inappropriate inflammatory reaction in AIDS induced by various factors including demodex and pityrosporon. Several therapeutic approaches have been proposed to eradicate the triggering factors and others to modify the immune response. The exceptional response to the short local treatment with corticosteroids would suggest that this approach could be proposed as first intention treatment in eosinophil folliculitis associated with AIDS.

Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Adult; Animals; Anti-Inflammatory Agents; Back; Betamethasone; Clobetasol; Drug Therapy, Combination; Eosinophilia; Facial Dermatoses; Female; Folliculitis; Glucocorticoids; Humans; Treatment Outcome

Topics: Administration, Cutaneous; Adult; Clobetasol; Eyelid Diseases; Facial Dermatoses; Female; Humans; Nose Diseases; Sarcoidosis; Skin Diseases

Topics: Adult; Clobetasol; Facial Dermatoses; Female; Humans; Nonprescription Drugs

Steroid creams applied topically to the skin are routinely used in the treatment of many dermatoses. Their use on the face in severe atopic eczema is relatively common. We report a series of three patients who whilst using topical facial steroids developed advanced glaucoma. A further two cases of ocular hypertension secondary to topical facial steroids are also described. This is the first series of cases to be reported demonstrating the potentially blinding complications of topical facial steroids. Recommendations are made with regard to screening such patients for glaucoma.

Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Clobetasol; Dermatitis, Atopic; Desoximetasone; Facial Dermatoses; Female; Glaucoma; Humans; Hydrocortisone; Male; Ocular Hypertension; Prednisolone; Vision Disorders; Visual Acuity

Topics: Administration, Cutaneous; Betamethasone; Clobetasol; Drug Administration Schedule; Facial Dermatoses; Female; Humans; Male; Ointments; Vitiligo

Topics: Adult; Betamethasone; Clobetasol; Dermatitis, Contact; Drug Eruptions; Facial Dermatoses; Hand Dermatoses; Humans; Male

Topics: Aged; Betamethasone; Clobetasol; Drug Eruptions; Eyelids; Facial Dermatoses; Female; Humans