clobetasol and Eye-Diseases

Clobetasone butyrate, a new corticosteroid with a high topical activity, has been compared with prednisolone phosphate and a placebo in the treatment of inflammation following cataract extraction. These 2 steroids were more effective in relieving postoperative inflammation than placebo (P less than 0.05), though no obvious clinical differences between the 2 compounds emerged from this investigation. However, a single-blind comparative study against betamethasone phosphate in patients suspected of having steroid-induced glaucoma showed that, while betamethasone phosphate significantly raised intraocular pressure, clobetasone butyrate had only a minimal effect, and this difference was statistically significant (P less than 0.02).

Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Betamethasone; Cataract Extraction; Clinical Trials as Topic; Clobetasol; Double-Blind Method; Eye Diseases; Female; Humans; Inflammation; Intraocular Pressure; Male; Middle Aged; Prednisolone