clobetasol and Coccidioidomycosis

Sweet syndrome (acute febrile neutrophilic dermatosis) may arise in association with a variety of underlying systemic diseases. Only 1 case of coccidioidomycosis-associated Sweet syndrome has previously been reported.. We describe 2 patients who developed Sweet syndrome during the onset of acute pulmonary coccidioidomycosis. Systemic antifungal therapy was given in both cases. Respiratory symptoms and skin lesions resolved within 5 weeks.. Sweet syndrome may be a presenting feature of coccidioidomycosis. Recognition of the underlying pulmonary infection is important so that inappropriate treatment with systemic corticosteroids can be avoided.

Topics: Administration, Oral; Administration, Topical; Aged; Biopsy, Needle; Clobetasol; Coccidioidomycosis; Drug Therapy, Combination; Female; Fluconazole; Follow-Up Studies; Humans; Immunohistochemistry; Lung Diseases, Fungal; Middle Aged; Risk Assessment; Severity of Illness Index; Sweet Syndrome; Treatment Outcome