clobetasol and Acne-Vulgaris

Postinflammatory hyperpigmentation (PIH) is the most common adverse effect of laser treatment in dark-skinned individuals. Little is known whether PIH can be prevented or minimised. The objective of this study was to investigate the effect of short-term application of topical corticosteroids on the incidence of PIH after ablative fractional resurfacing in Asians. Forty subjects with skin phototype IV and atrophic acne scars were treated with a fractional CO2 laser on both sides of the face. Post-operatively, clobetasol propionate 0.05% ointment was applied to one randomly selected side of the face for the first 2 days, followed by an application of petrolatum jelly for the rest of the week (petrolatum was applied to the other side for 7 days). Assessments on the clinical outcome, the wound healing process and the occurrence of PIH were obtained once weekly for the first month and at 2 and 3 months post-treatment. The side of the face treated with petrolatum alone had significantly (p < 0.001) higher incidence of PIH (75%) after laser irradiation than the side of the face treated with topical corticosteroids and petrolatum (40%). The PIH occurring on the petrolatum-treated sides had significantly higher intensity (p < 0.001) and was spread over a significantly larger area (p < 0.001), compared with the corticosteroid- and petrolatum-treated sides. In conclusion, a short-term application of topical corticosteroids postoperatively is associated with a decreased risk of PIH after ablative fractional resurfacing.

Topics: Acne Vulgaris; Administration, Cutaneous; Adrenal Cortex Hormones; Asian People; Cicatrix; Clobetasol; Dermatitis; Dermatologic Surgical Procedures; Female; Humans; Hyperpigmentation; Laser Therapy; Lasers, Gas; Male; Single-Blind Method; Skin Pigmentation; Thailand; Time Factors; Treatment Outcome

Topics: Acne Vulgaris; Administration, Cutaneous; Administration, Topical; Adrenal Glands; Adult; Anti-Inflammatory Agents; Betamethasone Valerate; Circadian Rhythm; Clobetasol; Drug Tolerance; Female; Humans; Hydrocortisone; Male; Methylprednisolone; Occlusive Dressings; Ointments; Time Factors

A controlled trial of the anti-inflammatory effect of a steroid cream (clobetasol propionate) in 11 patients with moderate acne was assessed over a 3 week period. The placebo cream was the base of the steroid cream. Therapeutic effect was assessed by the number of active and less actively inflamed papules and pustules present at the beginning and end of the 3 week trial period. No significant change in lesion counts was observed. This result indicates that a potent topical steroid cream produces no short-term improvement in patients with moderate acne.

Topics: Acne Vulgaris; Adolescent; Adult; Betamethasone; Clobetasol; Drug Evaluation; Female; Humans; Male; Ointments

Acne fulminans is a severe form of acne characterized by painful, inflammatory nodules that progress into ulcers and concurrent systemic symptoms. Treatment of acne with isotretinoin can precipitate a syndrome called isotretinoin-induced acne fulminans without systemic symptoms. An exuberant granulation tissue response, another known adverse event associated with isotretinoin, can occur concurrently, inhibiting wound repair and complicating treatment. We report a case of isotretinoin-induced acne fulminans without systemic symptoms with exuberant granulation tissue response that was treated successfully with topical clobetasol ointment.

Topics: Acne Vulgaris; Adolescent; Anti-Inflammatory Agents; Clobetasol; Connective Tissue Diseases; Dermatologic Agents; Humans; Isotretinoin; Male

Topics: Acne Vulgaris; Acute Generalized Exanthematous Pustulosis; Adult; Azathioprine; Azithromycin; Clobetasol; Crohn Disease; Drug Substitution; Female; Gastrointestinal Agents; Glucocorticoids; Humans; Infliximab; Remission Induction; Skin; Treatment Outcome

Follicular mucinosis can be a primary idiopathic disease or a secondary disease associated with lymphoma. When it appears in childhood or adolescence, it is usually primary and self-limited. We describe four cases of follicular mucinosis occurring in early adulthood that have had protracted courses. Each presented as an unusual acneiform eruption. Two of the cases demonstrated a clonal genetic rearrangement of the T-cell receptor within the cutaneous lymphoid infiltrate, a finding not previously reported. Although its significance is not clear, the clonal lymphocytic expansion indicates a need for continued surveillance of these patients.

Topics: Acne Vulgaris; Administration, Topical; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Clobetasol; Clone Cells; Diagnosis, Differential; Female; Follow-Up Studies; Gene Rearrangement, T-Lymphocyte; Glucocorticoids; Humans; Isotretinoin; Keratolytic Agents; Lymphocytes; Male; Minocycline; Mucinosis, Follicular; Receptors, Antigen, T-Cell; Tetracycline; Tretinoin

Topics: Acne Vulgaris; Adolescent; Betamethasone; Clobetasol; Granulation Tissue; Humans; Inflammation; Isotretinoin; Male; Tretinoin