clobenpropit has been researched along with Seizures in 8 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of seizures in mice and subsequent changes in brain histamine levels were estimated." | 7.77 | Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms. ( Khanam, R; Manocha, A; Uma Devi, P; Vohora, D, 2011) |
| "The purpose of this study was to investigate whether or not clobenpropit, a selective and potent histamine H(3) receptor antagonist, can protect from pentylenetetrazole (35 mg/kg)-kindled seizures in rats." | 7.72 | Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats. ( Chen, J; Chen, Z; Leurs, R; Ren, K; Timmerman, H; Wei, E; Ye, B; Zhang, L; Zhang, W, 2003) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 7.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| "In the maximal electroshock seizure threshold test, clobenpropit dose-dependently raised the electroconvulsive threshold for tonic (hindlimb extension) seizures, but a significant increase of about 15% was determined only at the high dose of 40 mg/kg i." | 5.30 | Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice. ( Fischer, W; van der Goot, H, 1998) |
| " Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of seizures in mice and subsequent changes in brain histamine levels were estimated." | 3.77 | Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms. ( Khanam, R; Manocha, A; Uma Devi, P; Vohora, D, 2011) |
| "The purpose of this study was to investigate whether or not clobenpropit, a selective and potent histamine H(3) receptor antagonist, can protect from pentylenetetrazole (35 mg/kg)-kindled seizures in rats." | 3.72 | Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats. ( Chen, J; Chen, Z; Leurs, R; Ren, K; Timmerman, H; Wei, E; Ye, B; Zhang, L; Zhang, W, 2003) |
| "The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats." | 3.70 | The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats. ( Fujii, Y; Fukunaga, M; Ishizawa, K; Kakinoki, H; Kamei, C, 1998) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 3.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| "In amygdaloid kindled seizures, electrodes were implanted into the right amygdala and electroencephalogram was recorded bipolarly; stimulation was applied bipolarly every day by a constant current stimulator and continued until a generalized convulsion was obtained." | 1.32 | Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia. ( Fujii, Y; Harada, C; Harusawa, S; Hirai, T; Kamei, C; Kurihara, T, 2004) |
| "In the maximal electroshock seizure threshold test, clobenpropit dose-dependently raised the electroconvulsive threshold for tonic (hindlimb extension) seizures, but a significant increase of about 15% was determined only at the high dose of 40 mg/kg i." | 1.30 | Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice. ( Fischer, W; van der Goot, H, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uma Devi, P | 1 |
| Manocha, A | 1 |
| Khanam, R | 1 |
| Vohora, D | 1 |
| Zhang, LS | 1 |
| Chen, Z | 3 |
| Huang, YW | 1 |
| Hu, WW | 1 |
| Wei, EQ | 1 |
| Yanai, K | 1 |
| Zhang, L | 1 |
| Ren, K | 1 |
| Leurs, R | 2 |
| Chen, J | 1 |
| Zhang, W | 1 |
| Ye, B | 1 |
| Wei, E | 1 |
| Timmerman, H | 2 |
| Harada, C | 1 |
| Hirai, T | 1 |
| Fujii, Y | 3 |
| Harusawa, S | 1 |
| Kurihara, T | 1 |
| Kamei, C | 3 |
| Yokoyama, H | 1 |
| Onodera, K | 1 |
| Maeyama, K | 1 |
| Sakurai, E | 1 |
| Iinuma, K | 1 |
| Watanabe, T | 1 |
| Kakinoki, H | 1 |
| Ishizawa, K | 2 |
| Fukunaga, M | 1 |
| Fischer, W | 1 |
| van der Goot, H | 1 |
| Okuma, C | 1 |
| Sugimoto, Y | 1 |
8 other studies available for clobenpropit and Seizures
| Article | Year |
|---|---|
Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms.
Topics: Animals; Anticonvulsants; Brain; Drug Interactions; Electroshock; Female; Histamine; Histamine H3 An | 2011 |
Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Histamine; Histamine Release; Histidine; | 2003 |
Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats.
Topics: Animals; Dose-Response Relationship, Drug; Imidazoles; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2003 |
Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia.
Topics: Amygdala; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; | 2004 |
Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Electroshock; Histamine Agonists; Histamine Antago | 1994 |
The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats.
Topics: Amygdala; Animals; Brain Chemistry; Enzyme Inhibitors; Histamine Antagonists; Histamine N-Methyltran | 1998 |
Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Differential Threshold; Electroshock; His | 1998 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, | 2000 |