clobenpropit has been researched along with Pancreatic Neoplasms in 1 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three kinds of human pancreatic cancer cell lines (Panc-1, MiaPaCa-2, and AsPC-1) were used in this study." | 1.40 | Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer. ( Jeong, KS; Kim, YT; Lee, SH; Paik, WH; Park, JM; Ryu, JK; Song, BJ; Yoon, YB, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paik, WH | 1 |
| Ryu, JK | 1 |
| Jeong, KS | 1 |
| Park, JM | 1 |
| Song, BJ | 1 |
| Lee, SH | 1 |
| Kim, YT | 1 |
| Yoon, YB | 1 |
1 other study available for clobenpropit and Pancreatic Neoplasms
| Article | Year |
|---|---|
Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2014 |