clobenpropit has been researched along with Obesity in 2 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leptin is a key signal linking peripheral adiposity levels to the regulation of energy homeostasis in the brain." | 5.35 | Comparison of the effect of an H(3)-inverse agonist on energy intake and hypothalamic histamine release in normal mice and leptin resistant mice with high fat diet-induced obesity. ( Hatano, K; Ishizuka, T; Murotani, T; Yamatodani, A, 2008) |
| "Leptin is a key signal linking peripheral adiposity levels to the regulation of energy homeostasis in the brain." | 1.35 | Comparison of the effect of an H(3)-inverse agonist on energy intake and hypothalamic histamine release in normal mice and leptin resistant mice with high fat diet-induced obesity. ( Hatano, K; Ishizuka, T; Murotani, T; Yamatodani, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jethwa, PH | 1 |
| Barrett, P | 1 |
| Turnbull, Y | 1 |
| Enright, RA | 1 |
| Warner, A | 1 |
| Murphy, M | 1 |
| Ebling, FJ | 1 |
| Ishizuka, T | 1 |
| Hatano, K | 1 |
| Murotani, T | 1 |
| Yamatodani, A | 1 |
2 other studies available for clobenpropit and Obesity
| Article | Year |
|---|---|
The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster.
Topics: Animals; Body Temperature; Cell Line, Transformed; Cricetinae; Disease Models, Animal; Eating; Hista | 2009 |
Comparison of the effect of an H(3)-inverse agonist on energy intake and hypothalamic histamine release in normal mice and leptin resistant mice with high fat diet-induced obesity.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Chromatography, High Pressure Liquid; | 2008 |