clobenpropit has been researched along with Muscle Contraction in 6 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stark, H | 1 |
| Sadek, B | 1 |
| Krause, M | 1 |
| Hüls, A | 1 |
| Ligneau, X | 1 |
| Ganellin, CR | 1 |
| Arrang, JM | 1 |
| Schwartz, JC | 1 |
| Schunack, W | 1 |
| De Esch, IJ | 2 |
| Mills, JE | 1 |
| Perkins, TD | 1 |
| Romeo, G | 1 |
| Hoffmann, M | 1 |
| Wieland, K | 1 |
| Leurs, R | 2 |
| Menge, WM | 1 |
| Nederkoorn, PH | 1 |
| Dean, PM | 1 |
| Timmerman, H | 2 |
| Wijtmans, M | 1 |
| Celanire, S | 1 |
| Snip, E | 1 |
| Gillard, MR | 1 |
| Gelens, E | 1 |
| Collart, PP | 1 |
| Venhuis, BJ | 1 |
| Christophe, B | 1 |
| Hulscher, S | 1 |
| van der Goot, H | 1 |
| Lebon, F | 1 |
| Bakker, RA | 1 |
| Lallemand, BI | 1 |
| Talaga, PE | 1 |
| Poli, E | 1 |
| Pozzoli, C | 1 |
| Bertaccini, G | 1 |
| Hahn, A | 1 |
| Huber, A | 1 |
| Neumayer, N | 1 |
| Allescher, HD | 1 |
| Valentine, AF | 1 |
| Rizzo, CA | 1 |
| Rivelli, MA | 1 |
| Hey, JA | 1 |
6 other studies available for clobenpropit and Muscle Contraction
| Article | Year |
|---|---|
Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds.
Topics: Animals; Atrial Function; Cerebral Cortex; Drug Evaluation, Preclinical; Guinea Pigs; Haplorhini; He | 2000 |
Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.
Topics: Animals; Benzyl Compounds; Cerebral Cortex; Guinea Pigs; Histamine Antagonists; Histamine Release; I | 2001 |
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.
Topics: Animals; CHO Cells; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Cytochrome P-450 Enz | 2008 |
Is there a role for histamine H3-receptors in the control of intestinal peristalsis?
Topics: Animals; Guinea Pigs; Histamine Agonists; Histamine Antagonists; Imidazoles; Intestine, Small; Male; | 1997 |
Effect of interleukin-1beta on the ascending and descending reflex in rat small intestine.
Topics: Animals; Cyclooxygenase Inhibitors; Electric Stimulation; Histamine Antagonists; Imidazoles; In Vitr | 1998 |
Pharmacological characterization of histamine H3 receptors in human saphenous vein and guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Aged; Animals; Dose-Response Relationship, Drug; Electric Stimulation; | 1999 |