clobenpropit has been researched along with Melanoma in 1 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously reported that histamine at micromolar concentrations reduces the proliferation of melanoma cell lines." | 7.77 | Role of H4 receptor in histamine-mediated responses in human melanoma. ( Bergoc, RM; Cricco, GP; Croci, M; Martinel Lamas, DJ; Massari, NA; Medina, VA; Rivera, ES; Sambuco, L, 2011) |
| "We have previously reported that histamine at micromolar concentrations reduces the proliferation of melanoma cell lines." | 3.77 | Role of H4 receptor in histamine-mediated responses in human melanoma. ( Bergoc, RM; Cricco, GP; Croci, M; Martinel Lamas, DJ; Massari, NA; Medina, VA; Rivera, ES; Sambuco, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Massari, NA | 1 |
| Medina, VA | 1 |
| Martinel Lamas, DJ | 1 |
| Cricco, GP | 1 |
| Croci, M | 1 |
| Sambuco, L | 1 |
| Bergoc, RM | 1 |
| Rivera, ES | 1 |
1 other study available for clobenpropit and Melanoma
| Article | Year |
|---|---|
Role of H4 receptor in histamine-mediated responses in human melanoma.
Topics: Cell Differentiation; Cell Growth Processes; Cell Line, Tumor; Guanidines; Histamine; Humans; Imidaz | 2011 |