clobenpropit has been researched along with Inflammation in 2 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine is a well known mediator of allergic skin diseases and, with the discovery of the histamine H(4) receptor, the role of histamine is re-evaluated." | 7.75 | The histamine H receptor as a new target for treatment of canine inflammatory skin diseases. ( Bäumer, W; Kietzmann, M; Leurs, R; Rossbach, K; Sander, K; Stark, H, 2009) |
| "Histamine is a well known mediator of allergic skin diseases and, with the discovery of the histamine H(4) receptor, the role of histamine is re-evaluated." | 3.75 | The histamine H receptor as a new target for treatment of canine inflammatory skin diseases. ( Bäumer, W; Kietzmann, M; Leurs, R; Rossbach, K; Sander, K; Stark, H, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rossbach, K | 2 |
| Wendorff, S | 1 |
| Sander, K | 2 |
| Stark, H | 2 |
| Gutzmer, R | 1 |
| Werfel, T | 1 |
| Kietzmann, M | 2 |
| Bäumer, W | 2 |
| Leurs, R | 1 |
2 other studies available for clobenpropit and Inflammation
| Article | Year |
|---|---|
Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.
Topics: Animals; Dermatitis, Atopic; Dose-Response Relationship, Drug; Female; Haptens; Histamine H1 Antagon | 2009 |
The histamine H receptor as a new target for treatment of canine inflammatory skin diseases.
Topics: Animals; Calcium; Cell Line; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Female; Guanidine | 2009 |