clobenpropit has been researched along with Idiopathic Parkinson Disease in 2 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, A | 2 |
| Muresanu, DF | 2 |
| Patnaik, R | 1 |
| Menon, PK | 1 |
| Tian, ZR | 2 |
| Sahib, S | 1 |
| Castellani, RJ | 1 |
| Nozari, A | 2 |
| Lafuente, JV | 2 |
| Buzoianu, AD | 2 |
| Skaper, SD | 1 |
| Bryukhovetskiy, I | 1 |
| Manzhulo, I | 1 |
| Wiklund, L | 2 |
| Sharma, HS | 2 |
| Feng, L | 1 |
| Huang, H | 1 |
| Chen, L | 1 |
2 reviews available for clobenpropit and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy.
Topics: Corpus Striatum; Histamine; Humans; Imidazoles; Neuroprotective Agents; Parkinson Disease; Receptors | 2021 |
Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson's Disease.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Antibodies, Monoclonal; Brain; Drug Inverse Agonism; Histami | 2023 |