clobenpropit has been researched along with Epilepsy in 1 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 7.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 3.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, LS | 1 |
| Shen, HQ | 1 |
| Jin, CL | 1 |
| Hu, WW | 1 |
| Zhao, MH | 1 |
| Chen, Z | 1 |
1 other study available for clobenpropit and Epilepsy
| Article | Year |
|---|---|
[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole].
Topics: Animals; Brain; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Histamine; Histidine; I | 2004 |