clobenpropit has been researched along with Drug Withdrawal Symptoms in 2 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, the influence of withdrawal from repeated administration of morphine on intra-ventral hippocampal microinjection of histamine-induced anxiety-like behavior was investigated in male Wistar rats." | 3.76 | Withdrawal from repeated administration of morphine alters histamine-induced anxiogenic effects produced by intra-ventral hippocampal microinjection. ( Khodarahmi, P; Oryan, S; Rezayof, A; Zarrindast, MR, 2010) |
| "Clobenpropit and histidine inhibit the revival of morphine-induced CPP in a dose dependent manner, indicating that endogenous histamine may inhibit relapse of morphine to some extent." | 1.35 | [Effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference]. ( Chen, Z; Gong, YX; Lu, M; Wang, HJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, HJ | 1 |
| Lu, M | 1 |
| Gong, YX | 1 |
| Chen, Z | 1 |
| Zarrindast, MR | 1 |
| Khodarahmi, P | 1 |
| Rezayof, A | 1 |
| Oryan, S | 1 |
2 other studies available for clobenpropit and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[Effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference].
Topics: Animals; Conditioning, Operant; Histidine; Imidazoles; Male; Morphine Dependence; Random Allocation; | 2009 |
Withdrawal from repeated administration of morphine alters histamine-induced anxiogenic effects produced by intra-ventral hippocampal microinjection.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Hippocampus; Histamine; Histamine Antagoni | 2010 |