clobenpropit has been researched along with Disease Models, Animal in 9 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission." | 7.81 | Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015) |
| " We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission." | 3.81 | Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015) |
| "The study investigated the effect of subchronic dosing (once daily, 7 days) of histamine H3 receptor (H3R) antagonists, ciproxifan (CPX) (3 mg/kg, i." | 1.43 | Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801. ( Akhtar, M; Goswami, D; Jahan, K; Mahmood, D, 2016) |
| "In amygdaloid kindled seizures, electrodes were implanted into the right amygdala and electroencephalogram was recorded bipolarly; stimulation was applied bipolarly every day by a constant current stimulator and continued until a generalized convulsion was obtained." | 1.32 | Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia. ( Fujii, Y; Harada, C; Harusawa, S; Hirai, T; Kamei, C; Kurihara, T, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Femenía, T | 1 |
| Magara, S | 1 |
| DuPont, CM | 1 |
| Lindskog, M | 1 |
| Mahmood, D | 1 |
| Akhtar, M | 1 |
| Jahan, K | 1 |
| Goswami, D | 1 |
| Yokota, E | 1 |
| Kuyama, S | 1 |
| Ogawa, M | 1 |
| Kamei, C | 2 |
| Jethwa, PH | 1 |
| Barrett, P | 1 |
| Turnbull, Y | 1 |
| Enright, RA | 1 |
| Warner, A | 1 |
| Murphy, M | 1 |
| Ebling, FJ | 1 |
| Godlewski, G | 1 |
| Malinowska, B | 1 |
| Schlicker, E | 1 |
| Harada, C | 1 |
| Hirai, T | 1 |
| Fujii, Y | 1 |
| Harusawa, S | 1 |
| Kurihara, T | 1 |
| Badenhorst, HE | 1 |
| Maharaj, DS | 1 |
| Malan, SF | 1 |
| Daya, S | 1 |
| van Dyk, S | 1 |
| Pérez-García, C | 1 |
| Morales, L | 1 |
| Cano, MV | 1 |
| Sancho, I | 1 |
| Alguacil, LF | 1 |
9 other studies available for clobenpropit and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Excit | 2015 |
Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Histam | 2016 |
Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice.
Topics: Animals; Capsaicin; Cetirizine; Disease Models, Animal; Female; Histamine; Histamine Agonists; Hista | 2008 |
The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster.
Topics: Animals; Body Temperature; Cell Line, Transformed; Cricetinae; Disease Models, Animal; Eating; Hista | 2009 |
Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats.
Topics: Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Blood Pressure; Camphane | 2004 |
Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia.
Topics: Amygdala; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; | 2004 |
Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates.
Topics: Animals; Antioxidants; Aspirin; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; His | 2005 |
Effects of histamine H3 receptor ligands in experimental models of anxiety and depression.
Topics: Analysis of Variance; Animals; Anxiety; Depression; Disease Models, Animal; Histamine Agonists; Hist | 1999 |