clobenpropit has been researched along with Dermatitis, Atopic in 2 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Dermatitis, Atopic: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rossbach, K | 1 |
| Wendorff, S | 1 |
| Sander, K | 1 |
| Stark, H | 2 |
| Gutzmer, R | 2 |
| Werfel, T | 2 |
| Kietzmann, M | 1 |
| Bäumer, W | 1 |
| Mommert, S | 1 |
| Gschwandtner, M | 1 |
| Zwingmann, K | 1 |
2 other studies available for clobenpropit and Dermatitis, Atopic
| Article | Year |
|---|---|
Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.
Topics: Animals; Dermatitis, Atopic; Dose-Response Relationship, Drug; Female; Haptens; Histamine H1 Antagon | 2009 |
The histamine H4 receptor is functionally expressed on T(H)2 cells.
Topics: Cells, Cultured; Dermatitis, Atopic; Histamine H3 Antagonists; Humans; Imidazoles; Interleukin-4; In | 2009 |