clobenpropit has been researched along with Convulsions, Grand Mal in 1 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In amygdaloid kindled seizures, electrodes were implanted into the right amygdala and electroencephalogram was recorded bipolarly; stimulation was applied bipolarly every day by a constant current stimulator and continued until a generalized convulsion was obtained." | 1.32 | Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia. ( Fujii, Y; Harada, C; Harusawa, S; Hirai, T; Kamei, C; Kurihara, T, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harada, C | 1 |
| Hirai, T | 1 |
| Fujii, Y | 1 |
| Harusawa, S | 1 |
| Kurihara, T | 1 |
| Kamei, C | 1 |
1 other study available for clobenpropit and Convulsions, Grand Mal
| Article | Year |
|---|---|
Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia.
Topics: Amygdala; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; | 2004 |