clobenpropit has been researched along with Chronic Disease in 1 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 7.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| "To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)." | 3.72 | [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, LS | 1 |
| Shen, HQ | 1 |
| Jin, CL | 1 |
| Hu, WW | 1 |
| Zhao, MH | 1 |
| Chen, Z | 1 |
1 other study available for clobenpropit and Chronic Disease
| Article | Year |
|---|---|
[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole].
Topics: Animals; Brain; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Histamine; Histidine; I | 2004 |