Page last updated: 2024-10-25

clobenpropit and Anxiety

clobenpropit has been researched along with Anxiety in 3 studies

clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
" We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission."7.81Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015)
" We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission."3.81Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015)
"In the present study, the influence of withdrawal from repeated administration of morphine on intra-ventral hippocampal microinjection of histamine-induced anxiety-like behavior was investigated in male Wistar rats."3.76Withdrawal from repeated administration of morphine alters histamine-induced anxiogenic effects produced by intra-ventral hippocampal microinjection. ( Khodarahmi, P; Oryan, S; Rezayof, A; Zarrindast, MR, 2010)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Femenía, T1
Magara, S1
DuPont, CM1
Lindskog, M1
Zarrindast, MR1
Khodarahmi, P1
Rezayof, A1
Oryan, S1
Pérez-García, C1
Morales, L1
Cano, MV1
Sancho, I1
Alguacil, LF1

Other Studies

3 other studies available for clobenpropit and Anxiety

ArticleYear
Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
    The international journal of neuropsychopharmacology, 2015, Mar-11, Volume: 18, Issue:9

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Excit

2015
Withdrawal from repeated administration of morphine alters histamine-induced anxiogenic effects produced by intra-ventral hippocampal microinjection.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:6

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Hippocampus; Histamine; Histamine Antagoni

2010
Effects of histamine H3 receptor ligands in experimental models of anxiety and depression.
    Psychopharmacology, 1999, Volume: 142, Issue:2

    Topics: Analysis of Variance; Animals; Anxiety; Depression; Disease Models, Animal; Histamine Agonists; Hist

1999