clobenpropit has been researched along with Anxiety in 3 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission." | 7.81 | Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015) |
| " We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission." | 3.81 | Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015) |
| "In the present study, the influence of withdrawal from repeated administration of morphine on intra-ventral hippocampal microinjection of histamine-induced anxiety-like behavior was investigated in male Wistar rats." | 3.76 | Withdrawal from repeated administration of morphine alters histamine-induced anxiogenic effects produced by intra-ventral hippocampal microinjection. ( Khodarahmi, P; Oryan, S; Rezayof, A; Zarrindast, MR, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Femenía, T | 1 |
| Magara, S | 1 |
| DuPont, CM | 1 |
| Lindskog, M | 1 |
| Zarrindast, MR | 1 |
| Khodarahmi, P | 1 |
| Rezayof, A | 1 |
| Oryan, S | 1 |
| Pérez-García, C | 1 |
| Morales, L | 1 |
| Cano, MV | 1 |
| Sancho, I | 1 |
| Alguacil, LF | 1 |
3 other studies available for clobenpropit and Anxiety
| Article | Year |
|---|---|
Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Excit | 2015 |
Withdrawal from repeated administration of morphine alters histamine-induced anxiogenic effects produced by intra-ventral hippocampal microinjection.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Hippocampus; Histamine; Histamine Antagoni | 2010 |
Effects of histamine H3 receptor ligands in experimental models of anxiety and depression.
Topics: Analysis of Variance; Animals; Anxiety; Depression; Disease Models, Animal; Histamine Agonists; Hist | 1999 |