clobenpropit has been researched along with Age-Related Memory Disorders in 4 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission." | 7.81 | Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015) |
| " We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission." | 3.81 | Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. ( DuPont, CM; Femenía, T; Lindskog, M; Magara, S, 2015) |
| "Learning and memory deficits, as evaluated on elevated plus maze, followed by estimation of brain AChE activity demonstrated positive results with these protypical imidazole H(3)R-antagonists/inverse agonists." | 1.38 | Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models. ( Akhtar, M; Khanam, R; Mahmood, D; Pillai, KK, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Femenía, T | 1 |
| Magara, S | 1 |
| DuPont, CM | 1 |
| Lindskog, M | 1 |
| Mahmood, D | 1 |
| Khanam, R | 1 |
| Pillai, KK | 1 |
| Akhtar, M | 1 |
| Huang, YW | 1 |
| Hu, WW | 1 |
| Chen, Z | 2 |
| Zhang, LS | 1 |
| Shen, HQ | 1 |
| Timmerman, H | 1 |
| Leurs, R | 1 |
| Yanai, K | 1 |
4 other studies available for clobenpropit and Age-Related Memory Disorders
| Article | Year |
|---|---|
Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Excit | 2015 |
Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Catalepsy; Female; Histamine Antagonists; Im | 2012 |
Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interacti | 2004 |
Effect of histamine H3-receptor antagonist clobenpropit on spatial memory of radial maze performance in rats.
Topics: Animals; Brain; Histamine; Histamine Antagonists; Imidazoles; Injections, Intraventricular; Male; Ma | 2000 |