clobenpropit has been researched along with Acute Confusional Senile Dementia in 2 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The in vitro model of Alzheimer's disease was constructed with A beta42-treated PC12 cells." | 1.34 | [Reversing effect of histamine on neurotoxicity induced by beta-amyloid1-42]. ( Chen, Z; Dai, HB; Fu, QL; Shen, Y, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patnaik, R | 1 |
| Sharma, A | 1 |
| Skaper, SD | 1 |
| Muresanu, DF | 1 |
| Lafuente, JV | 1 |
| Castellani, RJ | 1 |
| Nozari, A | 1 |
| Sharma, HS | 1 |
| Fu, QL | 1 |
| Dai, HB | 1 |
| Shen, Y | 1 |
| Chen, Z | 1 |
2 other studies available for clobenpropit and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Histamine H3 Inverse Agonist BF 2649 or Antagonist with Partial H4 Agonist Activity Clobenpropit Reduces Amyloid Beta Peptide-Induced Brain Pathology in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Drug Inverse Agonism; Drug Partial Agonism | 2018 |
[Reversing effect of histamine on neurotoxicity induced by beta-amyloid1-42].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Diphenhydramine; Dose-Response Re | 2007 |