clobazam has been researched along with Tuberous Sclerosis in 3 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Tuberous Sclerosis: Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clobazam (CLB) was recently approved by the FDA, but has not been evaluated in tuberous sclerosis complex (TSC)." | 7.79 | Clobazam therapy of refractory epilepsy in tuberous sclerosis complex. ( Caruso, PA; Jennesson, M; Paolini, JL; Thiele, EA; van Eeghen, AM, 2013) |
| "A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated within a paediatric epilepsy surgery program." | 5.42 | [Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis]. ( Blanco-Beregana, M; Budke, M; Fournier-Del Castillo, MC; Garcia-Fernandez, M; Garcia-Penas, JJ; Melero-Llorente, J; Perez-Jimenez, MÁ; Robles-Bermejo, F, 2015) |
| "Cannabidiol (CBD) has been shown to reduce seizures among patients with refractory epilepsies of various etiologies in recent clinical trials and an expanded access program (EAP)." | 4.02 | The long-term efficacy of cannabidiol in the treatment of refractory epilepsy. ( Bruno, PL; Fleming, B; Grinspoon, R; Patel, S; Skirvin, LA; Thiele, EA; Wade, C; Wolper, E, 2021) |
| "Clobazam (CLB) was recently approved by the FDA, but has not been evaluated in tuberous sclerosis complex (TSC)." | 3.79 | Clobazam therapy of refractory epilepsy in tuberous sclerosis complex. ( Caruso, PA; Jennesson, M; Paolini, JL; Thiele, EA; van Eeghen, AM, 2013) |
| "A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated within a paediatric epilepsy surgery program." | 1.42 | [Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis]. ( Blanco-Beregana, M; Budke, M; Fournier-Del Castillo, MC; Garcia-Fernandez, M; Garcia-Penas, JJ; Melero-Llorente, J; Perez-Jimenez, MÁ; Robles-Bermejo, F, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, S | 1 |
| Grinspoon, R | 1 |
| Fleming, B | 1 |
| Skirvin, LA | 1 |
| Wade, C | 1 |
| Wolper, E | 1 |
| Bruno, PL | 1 |
| Thiele, EA | 2 |
| Fournier-Del Castillo, MC | 1 |
| Melero-Llorente, J | 1 |
| Blanco-Beregana, M | 1 |
| Robles-Bermejo, F | 1 |
| Budke, M | 1 |
| Garcia-Fernandez, M | 1 |
| Garcia-Penas, JJ | 1 |
| Perez-Jimenez, MÁ | 1 |
| Jennesson, M | 1 |
| van Eeghen, AM | 1 |
| Caruso, PA | 1 |
| Paolini, JL | 1 |
3 other studies available for clobazam and Tuberous Sclerosis
| Article | Year |
|---|---|
The long-term efficacy of cannabidiol in the treatment of refractory epilepsy.
Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relations | 2021 |
[Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis].
Topics: Acetamides; Anticonvulsants; Benzodiazepines; Child; Clobazam; Cognition Disorders; Dibenzazepines; | 2015 |
Clobazam therapy of refractory epilepsy in tuberous sclerosis complex.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Epilepsy; Humans; M | 2013 |