clobazam has been researched along with Substance Withdrawal Syndrome in 8 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
Excerpt | Relevance | Reference |
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"Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal." | 9.05 | A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983) |
"To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)." | 5.40 | Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014) |
"Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal." | 5.05 | A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983) |
" In one approach, mice were chronically treated with either diazepam, clonazepam, clobazam or the novel anxiolytic and anticonvulsant beta-carboline derivative abecarnil for 4 weeks, at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole." | 3.69 | Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil. ( Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C, 1996) |
"To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)." | 1.40 | Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014) |
"Three patients aged 16, 19, and 65 years with a 13- to 36-year history of partial epilepsy were receiving a therapeutic dosage of carbamazepine or phenobarbital plus either clobazam (CLB) or valproate (VPA)." | 1.30 | Negative myoclonic status due to antiepileptic drug tapering: report of three cases. ( Aguglia, U; Gambardella, A; Oliveri, RL; Quattrone, A; Russo, C; Zappia, M, 1997) |
" During chronic administration of clobazam, 10 mg/kg 3 times daily, marked tolerance developed to the anticonvulsant and adverse (ataxiogenic and sedative) effects of the benzodiazepine." | 1.28 | Development of tolerance to clobazam in fully kindled rats: effects of intermittent flumazenil administration. ( Löscher, W; Rundfeldt, C, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (50.00) | 18.7374 |
1990's | 3 (37.50) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (12.50) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Tolbert, D | 1 |
Harris, SI | 1 |
Bekersky, I | 1 |
Lee, D | 1 |
Isojarvi, J | 1 |
Petursson, H | 1 |
Lader, MH | 1 |
de Figueiredo, R | 1 |
Franchini, A | 1 |
Martinho, A | 1 |
Hindmarch, I | 1 |
Lapierre, YD | 1 |
Tremblay, A | 1 |
Gagnon, A | 1 |
Monpremier, P | 1 |
Berliss, H | 1 |
Oyewumi, LK | 1 |
Mukherjee, PK | 1 |
Löscher, W | 2 |
Rundfeldt, C | 2 |
Hönack, D | 1 |
Ebert, U | 1 |
Gambardella, A | 1 |
Aguglia, U | 1 |
Oliveri, RL | 1 |
Russo, C | 1 |
Zappia, M | 1 |
Quattrone, A | 1 |
3 trials available for clobazam and Substance Withdrawal Syndrome
Article | Year |
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Differences in the effect of two benzodiazepines in the treatment of anxious outpatients.
Topics: Adult; Ambulatory Care; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Clinical T | 1981 |
A therapeutic and discontinuation study of clobazam and diazepam in anxiety neurosis.
Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clinical Trials a | 1982 |
A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism.
Topics: Adolescent; Adult; Aged; Alcoholism; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinone | 1983 |
5 other studies available for clobazam and Substance Withdrawal Syndrome
Article | Year |
---|---|
Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome.
Topics: Adult; Aged; Anticonvulsants; Anxiety Disorders; Benzodiazepines; Clobazam; Drug-Related Side Effect | 2014 |
Withdrawal reaction from clobazam.
Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clobazam; Humans; | 1981 |
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Cloba | 1996 |
Negative myoclonic status due to antiepileptic drug tapering: report of three cases.
Topics: Adolescent; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cerebral | 1997 |
Development of tolerance to clobazam in fully kindled rats: effects of intermittent flumazenil administration.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; | 1990 |