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clobazam and Substance Withdrawal Syndrome

clobazam has been researched along with Substance Withdrawal Syndrome in 8 studies

Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.

Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Research Excerpts

ExcerptRelevanceReference
"Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal."9.05A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983)
"To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)."5.40Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014)
"Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal."5.05A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983)
" In one approach, mice were chronically treated with either diazepam, clonazepam, clobazam or the novel anxiolytic and anticonvulsant beta-carboline derivative abecarnil for 4 weeks, at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole."3.69Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil. ( Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C, 1996)
"To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)."1.40Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014)
"Three patients aged 16, 19, and 65 years with a 13- to 36-year history of partial epilepsy were receiving a therapeutic dosage of carbamazepine or phenobarbital plus either clobazam (CLB) or valproate (VPA)."1.30Negative myoclonic status due to antiepileptic drug tapering: report of three cases. ( Aguglia, U; Gambardella, A; Oliveri, RL; Quattrone, A; Russo, C; Zappia, M, 1997)
" During chronic administration of clobazam, 10 mg/kg 3 times daily, marked tolerance developed to the anticonvulsant and adverse (ataxiogenic and sedative) effects of the benzodiazepine."1.28Development of tolerance to clobazam in fully kindled rats: effects of intermittent flumazenil administration. ( Löscher, W; Rundfeldt, C, 1990)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tolbert, D1
Harris, SI1
Bekersky, I1
Lee, D1
Isojarvi, J1
Petursson, H1
Lader, MH1
de Figueiredo, R1
Franchini, A1
Martinho, A1
Hindmarch, I1
Lapierre, YD1
Tremblay, A1
Gagnon, A1
Monpremier, P1
Berliss, H1
Oyewumi, LK1
Mukherjee, PK1
Löscher, W2
Rundfeldt, C2
Hönack, D1
Ebert, U1
Gambardella, A1
Aguglia, U1
Oliveri, RL1
Russo, C1
Zappia, M1
Quattrone, A1

Trials

3 trials available for clobazam and Substance Withdrawal Syndrome

ArticleYear
Differences in the effect of two benzodiazepines in the treatment of anxious outpatients.
    International pharmacopsychiatry, 1981, Volume: 16, Issue:1

    Topics: Adult; Ambulatory Care; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Clinical T

1981
A therapeutic and discontinuation study of clobazam and diazepam in anxiety neurosis.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:9

    Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clinical Trials a

1982
A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism.
    The Journal of international medical research, 1983, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Alcoholism; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinone

1983

Other Studies

5 other studies available for clobazam and Substance Withdrawal Syndrome

ArticleYear
Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome.
    Epilepsy & behavior : E&B, 2014, Volume: 37

    Topics: Adult; Aged; Anticonvulsants; Anxiety Disorders; Benzodiazepines; Clobazam; Drug-Related Side Effect

2014
Withdrawal reaction from clobazam.
    British medical journal (Clinical research ed.), 1981, Jun-13, Volume: 282, Issue:6280

    Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clobazam; Humans;

1981
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Cloba

1996
Negative myoclonic status due to antiepileptic drug tapering: report of three cases.
    Epilepsia, 1997, Volume: 38, Issue:7

    Topics: Adolescent; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cerebral

1997
Development of tolerance to clobazam in fully kindled rats: effects of intermittent flumazenil administration.
    European journal of pharmacology, 1990, May-16, Volume: 180, Issue:2-3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones;

1990