clobazam has been researched along with Low Back Ache in 3 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thermal QST have the potential to predict imipramine effect in chronic low back pain." | 5.27 | Predicting drug efficacy in chronic low back pain by quantitative sensory tests. ( Arendt-Nielsen, L; Bütikofer, L; Curatolo, M; Jüni, P; Schliessbach, J; Siegenthaler, A; Stamer, U; Vuilleumier, P, 2018) |
| "In this randomized, double blinded, placebo controlled cross-over study, patients with chronic low back pain are randomly assigned to imipramine, oxycodone or clobazam versus active placebo." | 5.20 | Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain. ( Arendt-Nielsen, L; Curatolo, M; Juni, P; Schliessbach, J; Siegenthaler, A; Vuilleumier, PH; Zeilhofer, HU, 2015) |
| "Chronic pain is frequently associated with hypersensitivity of the nervous system, and drugs that increase central inhibition are therefore a potentially effective treatment." | 2.84 | Analgesic effect of clobazam in chronic low-back pain but not in experimentally induced pain. ( Arendt-Nielsen, L; Bütikofer, L; Curatolo, M; Juni, P; Limacher, A; Schliessbach, J; Siegenthaler, A; Vuilleumier, PH; Zeilhofer, HU, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schliessbach, J | 3 |
| Vuilleumier, PH | 2 |
| Siegenthaler, A | 3 |
| Bütikofer, L | 2 |
| Limacher, A | 1 |
| Juni, P | 3 |
| Zeilhofer, HU | 2 |
| Arendt-Nielsen, L | 3 |
| Curatolo, M | 3 |
| Vuilleumier, P | 1 |
| Stamer, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain[NCT01179828] | Phase 3 | 150 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for clobazam and Low Back Ache
| Article | Year |
|---|---|
Analgesic effect of clobazam in chronic low-back pain but not in experimentally induced pain.
Topics: Adult; Aged; Anticonvulsants; Benzodiazepines; Chronic Pain; Clobazam; Cross-Over Studies; Double-Bl | 2017 |
Predicting drug efficacy in chronic low back pain by quantitative sensory tests.
Topics: Adult; Aged; Analgesics; Clobazam; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fe | 2018 |
Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain.
Topics: Adolescent; Adult; Aged; Analgesics; Benzodiazepines; Chronic Pain; Clinical Protocols; Clobazam; Cr | 2015 |