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clobazam and Epilepsy, Temporal Lobe

clobazam has been researched along with Epilepsy, Temporal Lobe in 12 studies

Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.

Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).

Research Excerpts

ExcerptRelevanceReference
"Here, one such patient became seizure free, allowing us to identify and compare the changes in hippocampal electrophysiology associated with ANT stimulation and seizure freedom."5.91Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography. ( Brandman, DM; Bullinger, K; Gross, RE; Isbaine, F; Skelton, HM, 2023)
"Clobazam is a benzodiazepine with known antiepileptic action; however, it is not considered first line therapy in the treatment of epilepsy."5.33Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosis. ( Cendes, F; Ferreira, CM; Guerreiro, CA; Li, LM; Montenegro, MA, 2005)
" Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy."4.76[Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983)
"Here, one such patient became seizure free, allowing us to identify and compare the changes in hippocampal electrophysiology associated with ANT stimulation and seizure freedom."1.91Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography. ( Brandman, DM; Bullinger, K; Gross, RE; Isbaine, F; Skelton, HM, 2023)
"Conclusions Depressive disorders are common, underdiagnosed and undertreated in patients with refractory MTLE."1.48Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy. ( Cendes, F; de Oliveira Cardoso, TAM; Gonçalves, EB; Yasuda, CL, 2018)
"Carbamazepine was progressively withdrawn and the patient was progressively switched to zonisamide."1.35Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. ( Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R, 2009)
"Clobazam is a benzodiazepine with known antiepileptic action; however, it is not considered first line therapy in the treatment of epilepsy."1.33Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosis. ( Cendes, F; Ferreira, CM; Guerreiro, CA; Li, LM; Montenegro, MA, 2005)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19905 (41.67)18.7374
1990's1 (8.33)18.2507
2000's3 (25.00)29.6817
2010's2 (16.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Skelton, HM1
Brandman, DM1
Bullinger, K1
Isbaine, F1
Gross, RE1
Androsova, G1
Krause, R1
Borghei, M1
Wassenaar, M1
Auce, P1
Avbersek, A1
Becker, F1
Berghuis, B1
Campbell, E1
Coppola, A1
Francis, B1
Wolking, S1
Cavalleri, GL1
Craig, J1
Delanty, N1
Koeleman, BPC1
Kunz, WS1
Lerche, H1
Marson, AG1
Sander, JW1
Sills, GJ1
Striano, P1
Zara, F1
Sisodiya, SM1
Depondt, C1
Gonçalves, EB1
de Oliveira Cardoso, TAM1
Yasuda, CL1
Cendes, F2
da Rocha, FF1
Bamberg, TO1
Lage, NV1
Correa, H1
Teixeira, AL1
Crespel, A1
Velizarova, R1
Genton, P1
Coubes, P1
Gélisse, P1
Montenegro, MA1
Ferreira, CM1
Li, LM1
Guerreiro, CA1
Loiseau, P1
Pechadre, JC1
Beudin, P1
Devoize, JL1
Gibert, J1
Maher, J1
McLachlan, RS1
Bravaccio, F1
D'Ambrosio, G1
De Rosa, A1
Tata, MR1
Volpe, E1
Larrieu, JL1
Lagueny, A1
Ferrer, X1
Julien, J1
Heller, AJ1
Ring, HA1
Reynolds, EH1

Reviews

1 review available for clobazam and Epilepsy, Temporal Lobe

ArticleYear
[Benzodiazepines in the treatment of epilepsy].
    L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam

1983

Trials

1 trial available for clobazam and Epilepsy, Temporal Lobe

ArticleYear
Antiepileptic drug treatment following temporal lobectomy.
    Neurology, 1998, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama

1998

Other Studies

10 other studies available for clobazam and Epilepsy, Temporal Lobe

ArticleYear
Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography.
    Stereotactic and functional neurosurgery, 2023, Volume: 101, Issue:6

    Topics: Biomarkers; Clobazam; Deep Brain Stimulation; Drug Resistant Epilepsy; Electrocorticography; Epileps

2023
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
    Epilepsia, 2017, Volume: 58, Issue:10

    Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam;

2017
Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy.
    The Journal of international medical research, 2018, Volume: 46, Issue:2

    Topics: Adult; Anticonvulsants; Antidepressive Agents; Benzodiazepines; Carbamazepine; Clobazam; Depressive

2018
Obsessive-compulsive disorder secondary to temporal lobe epilepsy with response to carbamazepine treatment.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Apr-30, Volume: 33, Issue:3

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Epilepsy, Temporal Lobe; Female; Humans;

2009
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
    Neurophysiologie clinique = Clinical neurophysiology, 2009, Volume: 39, Issue:3

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Thera

2009
Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosis.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2005, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Clobazam; Drug Therapy, Combination; Epil

2005
[Anti-epileptic effect of clobazam in Lennox-Gastaut syndrome (author's transl)].
    L'Encephale, 1981, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child;

1981
[The anti-epileptic properties of a diazepine drug (clobazam). Preliminary results].
    Acta neurologica. Quaderni, 1979, Volume: 39

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Clobazam; Epilepsy; Epilepsy,

1979
[Epilepsy with continuous discharges during slow-wave sleep. Treatment with clobazam].
    Revue d'electroencephalographie et de neurophysiologie clinique, 1986, Volume: 16, Issue:4

    Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clo

1986
Clobazam for refractory epilepsy.
    Archives of neurology, 1987, Volume: 44, Issue:6

    Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Drug Resistance; Epilepsy, Tempor

1987