clobazam has been researched along with Epilepsy, Temporal Lobe in 12 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, one such patient became seizure free, allowing us to identify and compare the changes in hippocampal electrophysiology associated with ANT stimulation and seizure freedom." | 5.91 | Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography. ( Brandman, DM; Bullinger, K; Gross, RE; Isbaine, F; Skelton, HM, 2023) |
| "Clobazam is a benzodiazepine with known antiepileptic action; however, it is not considered first line therapy in the treatment of epilepsy." | 5.33 | Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosis. ( Cendes, F; Ferreira, CM; Guerreiro, CA; Li, LM; Montenegro, MA, 2005) |
| " Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy." | 4.76 | [Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983) |
| "Here, one such patient became seizure free, allowing us to identify and compare the changes in hippocampal electrophysiology associated with ANT stimulation and seizure freedom." | 1.91 | Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography. ( Brandman, DM; Bullinger, K; Gross, RE; Isbaine, F; Skelton, HM, 2023) |
| "Conclusions Depressive disorders are common, underdiagnosed and undertreated in patients with refractory MTLE." | 1.48 | Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy. ( Cendes, F; de Oliveira Cardoso, TAM; Gonçalves, EB; Yasuda, CL, 2018) |
| "Carbamazepine was progressively withdrawn and the patient was progressively switched to zonisamide." | 1.35 | Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. ( Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R, 2009) |
| "Clobazam is a benzodiazepine with known antiepileptic action; however, it is not considered first line therapy in the treatment of epilepsy." | 1.33 | Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosis. ( Cendes, F; Ferreira, CM; Guerreiro, CA; Li, LM; Montenegro, MA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Skelton, HM | 1 |
| Brandman, DM | 1 |
| Bullinger, K | 1 |
| Isbaine, F | 1 |
| Gross, RE | 1 |
| Androsova, G | 1 |
| Krause, R | 1 |
| Borghei, M | 1 |
| Wassenaar, M | 1 |
| Auce, P | 1 |
| Avbersek, A | 1 |
| Becker, F | 1 |
| Berghuis, B | 1 |
| Campbell, E | 1 |
| Coppola, A | 1 |
| Francis, B | 1 |
| Wolking, S | 1 |
| Cavalleri, GL | 1 |
| Craig, J | 1 |
| Delanty, N | 1 |
| Koeleman, BPC | 1 |
| Kunz, WS | 1 |
| Lerche, H | 1 |
| Marson, AG | 1 |
| Sander, JW | 1 |
| Sills, GJ | 1 |
| Striano, P | 1 |
| Zara, F | 1 |
| Sisodiya, SM | 1 |
| Depondt, C | 1 |
| Gonçalves, EB | 1 |
| de Oliveira Cardoso, TAM | 1 |
| Yasuda, CL | 1 |
| Cendes, F | 2 |
| da Rocha, FF | 1 |
| Bamberg, TO | 1 |
| Lage, NV | 1 |
| Correa, H | 1 |
| Teixeira, AL | 1 |
| Crespel, A | 1 |
| Velizarova, R | 1 |
| Genton, P | 1 |
| Coubes, P | 1 |
| Gélisse, P | 1 |
| Montenegro, MA | 1 |
| Ferreira, CM | 1 |
| Li, LM | 1 |
| Guerreiro, CA | 1 |
| Loiseau, P | 1 |
| Pechadre, JC | 1 |
| Beudin, P | 1 |
| Devoize, JL | 1 |
| Gibert, J | 1 |
| Maher, J | 1 |
| McLachlan, RS | 1 |
| Bravaccio, F | 1 |
| D'Ambrosio, G | 1 |
| De Rosa, A | 1 |
| Tata, MR | 1 |
| Volpe, E | 1 |
| Larrieu, JL | 1 |
| Lagueny, A | 1 |
| Ferrer, X | 1 |
| Julien, J | 1 |
| Heller, AJ | 1 |
| Ring, HA | 1 |
| Reynolds, EH | 1 |
1 review available for clobazam and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
[Benzodiazepines in the treatment of epilepsy].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam | 1983 |
1 trial available for clobazam and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Antiepileptic drug treatment following temporal lobectomy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1998 |
10 other studies available for clobazam and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography.
Topics: Biomarkers; Clobazam; Deep Brain Stimulation; Drug Resistant Epilepsy; Electrocorticography; Epileps | 2023 |
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam; | 2017 |
Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Benzodiazepines; Carbamazepine; Clobazam; Depressive | 2018 |
Obsessive-compulsive disorder secondary to temporal lobe epilepsy with response to carbamazepine treatment.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Epilepsy, Temporal Lobe; Female; Humans; | 2009 |
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Thera | 2009 |
Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Clobazam; Drug Therapy, Combination; Epil | 2005 |
[Anti-epileptic effect of clobazam in Lennox-Gastaut syndrome (author's transl)].
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; | 1981 |
[The anti-epileptic properties of a diazepine drug (clobazam). Preliminary results].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Clobazam; Epilepsy; Epilepsy, | 1979 |
[Epilepsy with continuous discharges during slow-wave sleep. Treatment with clobazam].
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clo | 1986 |
Clobazam for refractory epilepsy.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Drug Resistance; Epilepsy, Tempor | 1987 |