clobazam has been researched along with Enlarged Liver in 1 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Cyp2b1, Cyp3a1, Cyp3a2, and Ugt2b2 mRNA levels in the liver were upregulated as compared to the control group throughout the dosing period." | 1.37 | Toxicological approach for elucidation of clobazam-induced hepatomegaly in male rats. ( Funabashi, H; Horie, H; Inada, H; Kimura, J; Matsumoto, I; Miyawaki, I; Seki, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyawaki, I | 1 |
| Matsumoto, I | 1 |
| Horie, H | 1 |
| Inada, H | 1 |
| Kimura, J | 1 |
| Funabashi, H | 1 |
| Seki, T | 1 |
1 other study available for clobazam and Enlarged Liver
| Article | Year |
|---|---|
Toxicological approach for elucidation of clobazam-induced hepatomegaly in male rats.
Topics: Animals; Anticonvulsants; Apoptosis; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Cell Proliferat | 2011 |