clobazam has been researched along with Convulsive Generalized Seizure Disorder in 12 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy." | 9.08 | Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998) |
| "To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures." | 8.98 | Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018) |
| "To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures." | 8.90 | Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014) |
| "To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy." | 5.08 | Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998) |
| "To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures." | 4.98 | Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018) |
| "To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures." | 4.90 | Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014) |
| "Clobazam (CLB) is an effective anticonvulsant used as an adjunctive treatment for several seizures and epilepsy syndromes." | 4.12 | CLB add-on treatment in patients with epileptic encephalopathy: a single center experience with long-term follow-up. ( Öztürk, G; Türkdoğan, D, 2022) |
| "Clobazam offers a new treatment option for patients with refractory epilepsy." | 2.48 | Clobazam for treatment of epilepsy. ( Benbadis, SR; Giarratano, M; Standley, K, 2012) |
| "Minimal, predominantly clonic seizures with preserved righting ability were reliably induced by pentylenetetrazol and suppressed by clobazam in rats aged 18 days or more." | 1.30 | Antipentylenetetrazol action of clobazam in developing rats. ( Haugvicová, R; Kubová, H; Mares, P, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Gimigliano, F | 1 |
| Türkdoğan, D | 1 |
| Öztürk, G | 1 |
| Arya, R | 2 |
| Giridharan, N | 1 |
| Anand, V | 2 |
| Garg, SK | 2 |
| Michael, BD | 1 |
| Martínez-Rivera, V | 1 |
| Martínez-Antón, J | 1 |
| Giarratano, M | 1 |
| Standley, K | 1 |
| Benbadis, SR | 1 |
| Veggiotti, P | 1 |
| Termine, C | 1 |
| Granocchio, E | 1 |
| Bova, S | 1 |
| Papalia, G | 1 |
| Lanzi, G | 1 |
| Mayer, T | 1 |
| Specht, U | 1 |
| Bourgeois, B | 1 |
| Dhossche, D | 1 |
| Petrides, G | 1 |
| Haugvicová, R | 1 |
| Kubová, H | 1 |
| Mares, P | 1 |
5 reviews available for clobazam and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Is clobazam monotherapy effective and safe in people with focal or generalized seizures? A Cochrane Review summary with commentary.
Topics: Anticonvulsants; Clobazam; Epilepsies, Partial; Epilepsy, Generalized; Humans | 2020 |
Clobazam monotherapy for focal or generalized seizures.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par | 2018 |
Clobazam monotherapy for partial-onset or generalized-onset seizures.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par | 2014 |
Clobazam for treatment of epilepsy.
Topics: Anticonvulsants; Benzodiazepines; Clobazam; Epilepsy, Generalized; Humans | 2012 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera | 1995 |
3 trials available for clobazam and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Long-term neuropsychological follow-up and nosological considerations in five patients with continuous spikes and waves during slow sleep.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Pr | 2002 |
Propranolol in startle induced epileptic seizures.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clob | 1995 |
Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy.
Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; C | 1998 |
4 other studies available for clobazam and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
CLB add-on treatment in patients with epileptic encephalopathy: a single center experience with long-term follow-up.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clobazam; Drug Therapy, Combination; Epilepsie | 2022 |
[Hyperekplexia associated to precocious puberty].
Topics: Anticonvulsants; Benzodiazepines; Cerebral Palsy; Child; Clobazam; Drug Therapy, Combination; Electr | 2015 |
Negative symptoms or catatonia?
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Benzodiazepinones; Child; Clobazam; Cloz | 1997 |
Antipentylenetetrazol action of clobazam in developing rats.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Convul | 1999 |