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clobazam and Convulsions, Grand Mal

clobazam has been researched along with Convulsions, Grand Mal in 6 studies

Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.

Research Excerpts

ExcerptRelevanceReference
"To survey the treatment situation of Dravet syndrome in Japan and to compare this result with effectiveness of stiripentol (STP) add-on therapy in an open-label multicenter study."7.75Stiripentol open study in Japanese patients with Dravet syndrome. ( Baba, H; Fukushima, K; Ikeda, S; Inoue, Y; Oguni, H; Ohtani, H; Ohtsuka, Y; Takahashi, Y; Tohyama, J, 2009)
"These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection."5.28Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992)
"To survey the treatment situation of Dravet syndrome in Japan and to compare this result with effectiveness of stiripentol (STP) add-on therapy in an open-label multicenter study."3.75Stiripentol open study in Japanese patients with Dravet syndrome. ( Baba, H; Fukushima, K; Ikeda, S; Inoue, Y; Oguni, H; Ohtani, H; Ohtsuka, Y; Takahashi, Y; Tohyama, J, 2009)
"Carbamazepine was progressively withdrawn and the patient was progressively switched to zonisamide."1.35Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. ( Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R, 2009)
"These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection."1.28Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Inoue, Y1
Ohtsuka, Y1
Oguni, H1
Tohyama, J1
Baba, H1
Fukushima, K1
Ohtani, H1
Takahashi, Y1
Ikeda, S1
Crespel, A1
Velizarova, R1
Genton, P1
Coubes, P1
Gélisse, P1
Buchanan, N1
Miura, Y1
Amano, S1
Torii, R1
Ihara, N1
Bravaccio, F1
D'Ambrosio, G1
De Rosa, A1
Tata, MR1
Volpe, E1
Terra, VC1
Garcia-Cairasco, N1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]Phase 22 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

InterventionAbscence seizures (Number)
Week 8 Baseline165
Week 12 Verapamil 4mg/kg/Day101

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionGeneral tonic-clonic seizures (Number)
Week 8 Baseline39
Week 12 Verapamil 4mg/kg/Day14

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionMyoclonic seizures (Number)
Week 8 Baseline116
Week 12 Verapamil 4mg/kg/Day175

Other Studies

6 other studies available for clobazam and Convulsions, Grand Mal

ArticleYear
Stiripentol open study in Japanese patients with Dravet syndrome.
    Epilepsia, 2009, Volume: 50, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Child; Child, Pr

2009
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
    Neurophysiologie clinique = Clinical neurophysiology, 2009, Volume: 39, Issue:3

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Thera

2009
Clobazam in the treatment of epilepsy: prospective follow-up to 8 years.
    Journal of the Royal Society of Medicine, 1993, Volume: 86, Issue:7

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child;

1993
Clobazam shows a different antiepileptic action profile from clonazepam and zonisamide in Ihara epileptic rats.
    Epilepsy research, 2002, Volume: 49, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Circadian Rhythm; Clobazam; Clonazep

2002
[The anti-epileptic properties of a diazepine drug (clobazam). Preliminary results].
    Acta neurologica. Quaderni, 1979, Volume: 39

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Clobazam; Epilepsy; Epilepsy,

1979
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections.
    Behavioural brain research, 1992, Nov-30, Volume: 52, Issue:1

    Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Arousal; Behavior, Animal; Benz

1992