clobazam has been researched along with Aggression in 4 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with benzodiazepines, including clobazam, may increase aggression/behavioral problems in patients with Lennox-Gastaut syndrome." | 9.20 | Clobazam and Aggression-Related Adverse Events in Pediatric Patients With Lennox-Gastaut Syndrome. ( Drummond, R; Isojarvi, J; Lee, D; Paolicchi, JM; Ross, G, 2015) |
| "Seven of 63 children (11%) treated with clobazam (CLB) for refractory epilepsy developed a severe behavior disorder." | 9.07 | Aggression in children treated with clobazam for epilepsy. ( Goulden, KJ; Ronen, GM; Sheth, RD, 1994) |
| " Treatment with benzodiazepines, including clobazam, may increase aggression/behavioral problems in patients with Lennox-Gastaut syndrome." | 5.20 | Clobazam and Aggression-Related Adverse Events in Pediatric Patients With Lennox-Gastaut Syndrome. ( Drummond, R; Isojarvi, J; Lee, D; Paolicchi, JM; Ross, G, 2015) |
| "Seven of 63 children (11%) treated with clobazam (CLB) for refractory epilepsy developed a severe behavior disorder." | 5.07 | Aggression in children treated with clobazam for epilepsy. ( Goulden, KJ; Ronen, GM; Sheth, RD, 1994) |
| "Enciprazine was selected for clinical investigations." | 1.28 | Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. ( Engel, J; Fleischhauer, I; Jakovlev, V; Johanson, CE; Kleemann, A; Kutscher, B; Nickel, B; Rauer, H; Szelenyi, I; Werner, U, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Engel, J | 1 |
| Fleischhauer, I | 1 |
| Jakovlev, V | 1 |
| Kleemann, A | 1 |
| Kutscher, B | 1 |
| Nickel, B | 1 |
| Rauer, H | 1 |
| Werner, U | 1 |
| Szelenyi, I | 1 |
| Johanson, CE | 1 |
| Paolicchi, JM | 1 |
| Ross, G | 1 |
| Lee, D | 1 |
| Drummond, R | 1 |
| Isojarvi, J | 1 |
| Sheth, RD | 1 |
| Goulden, KJ | 1 |
| Ronen, GM | 1 |
| Griebel, G | 1 |
| Perrault, G | 1 |
| Sanger, DJ | 1 |
2 trials available for clobazam and Aggression
| Article | Year |
|---|---|
Clobazam and Aggression-Related Adverse Events in Pediatric Patients With Lennox-Gastaut Syndrome.
Topics: Adolescent; Aggression; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Double- | 2015 |
Aggression in children treated with clobazam for epilepsy.
Topics: Aggression; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; Child B | 1994 |
2 other studies available for clobazam and Aggression
| Article | Year |
|---|---|
Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Chemical Phenomena; Chemistry; Explorato | 1990 |
Differences in anxiolytic-like profile of two novel nonbenzodiazepine BZ (omega) receptor agonists on defensive behaviors of mice.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Benzimidazoles; Benzodiazepines; Benzo | 1999 |