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clobazam and Absence Status

clobazam has been researched along with Absence Status in 19 studies

Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.

Research Excerpts

ExcerptRelevanceReference
"The authors administered clobazam (CLB) to treat status epilepticus in 16 patients from 3 to 62 years old."7.67[Treatment of certain forms of status epilepticus by means of a single oral dose of clobazam]. ( Aguglia, U; Gastaut, H; Lugaresi, E; Tinuper, P, 1984)
"Sixteen patients with status epilepticus (SE) and 13 patients suffering from startle-induced epilepsy were treated with clobazam (CLB)."7.67Use of clobazam in certain forms of status epilepticus and in startle-induced epileptic seizures. ( Aguglia, U; Gastaut, H; Tinuper, P, 1986)
"Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties."5.43Effects of clobazam for treatment of refractory status epilepticus. ( Gerner, ST; Geyer, A; Gollwitzer, S; Hamer, HM; Huttner, HB; Knappe, RU; Kuramatsu, JB; Madžar, D, 2016)
"Clobazam was introduced after a median duration of 4 days and after a median of three failed antiepileptic drugs."5.42Clobazam: An effective add-on therapy in refractory status epilepticus. ( Ibrahim, M; Mohamed, W; Norris, G; Parker, D; Shah, A; Sivakumar, S, 2015)
"To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)."5.40Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014)
" However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety."5.37Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011)
" Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy."4.76[Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983)
"The authors administered clobazam (CLB) to treat status epilepticus in 16 patients from 3 to 62 years old."3.67[Treatment of certain forms of status epilepticus by means of a single oral dose of clobazam]. ( Aguglia, U; Gastaut, H; Lugaresi, E; Tinuper, P, 1984)
"Sixteen patients with status epilepticus (SE) and 13 patients suffering from startle-induced epilepsy were treated with clobazam (CLB)."3.67Use of clobazam in certain forms of status epilepticus and in startle-induced epileptic seizures. ( Aguglia, U; Gastaut, H; Tinuper, P, 1986)
"Recent studies support the initial treatment of status epilepticus with early and aggressive benzodiazepine dosing."2.55Advancements in the critical care management of status epilepticus. ( Bauerschmidt, A; Claassen, J; Martin, A, 2017)
"Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties."1.43Effects of clobazam for treatment of refractory status epilepticus. ( Gerner, ST; Geyer, A; Gollwitzer, S; Hamer, HM; Huttner, HB; Knappe, RU; Kuramatsu, JB; Madžar, D, 2016)
"Clobazam was introduced after a median duration of 4 days and after a median of three failed antiepileptic drugs."1.42Clobazam: An effective add-on therapy in refractory status epilepticus. ( Ibrahim, M; Mohamed, W; Norris, G; Parker, D; Shah, A; Sivakumar, S, 2015)
"To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)."1.40Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014)
" However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety."1.37Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011)
"Spasms in series and hypsarrhythmia disappeared after treatment with high-dose phenobarbital; however, single spasms persisted with right-sided predominance, and polyspike activity in the left parieto-temporal areas preceded or coincided with these spasms."1.36Non-convulsive status epilepticus and audiogenic seizures complicating a patient with asymmetrical epileptic spasms. ( Hoshino, K; Komaki, H; Nakagawa, E; Saito, Y; Sakuma, H; Sasaki, M; Sugai, K, 2010)
"Three patients aged 16, 19, and 65 years with a 13- to 36-year history of partial epilepsy were receiving a therapeutic dosage of carbamazepine or phenobarbital plus either clobazam (CLB) or valproate (VPA)."1.30Negative myoclonic status due to antiepileptic drug tapering: report of three cases. ( Aguglia, U; Gambardella, A; Oliveri, RL; Quattrone, A; Russo, C; Zappia, M, 1997)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.79)18.7374
1990's1 (5.26)18.2507
2000's4 (21.05)29.6817
2010's7 (36.84)24.3611
2020's4 (21.05)2.80

Authors

AuthorsStudies
Sager, SG1
Turkyilmaz, A1
Gunbey, HP1
Karatoprak, EY1
Aslan, ES1
Akın, Y1
Specchio, N1
Pietrafusa, N1
Ferretti, A1
Trivisano, M1
Vigevano, F1
Deng, L1
Ma, A1
Wood, N1
Ardern-Holmes, S1
van den Munckhof, B1
Arzimanoglou, A1
Perucca, E1
van Teeseling, HC1
Leijten, FSS1
Braun, KPJ1
Jansen, FE1
Tolbert, D1
Harris, SI1
Bekersky, I1
Lee, D1
Isojarvi, J1
Sivakumar, S1
Ibrahim, M1
Parker, D1
Norris, G1
Shah, A1
Mohamed, W1
Madžar, D1
Geyer, A1
Knappe, RU1
Gollwitzer, S1
Kuramatsu, JB1
Gerner, ST1
Hamer, HM1
Huttner, HB1
Bauerschmidt, A1
Martin, A1
Claassen, J1
Carota, A1
Novy, J1
Rossetti, AO1
Saito, Y1
Sugai, K1
Nakagawa, E1
Sakuma, H1
Komaki, H1
Sasaki, M1
Hoshino, K1
Florence, K1
Manisha, L1
Kumar, BA1
Ankur, K1
Kumar, MA1
Ambikanandan, M1
Galimi, R1
Yoshimura, K1
Goldsmith, J1
McKnight, C1
Dickson, S1
Heenan, M1
Berezowski, R1
Cooper, J1
Feely, M1
Loiseau, P1
Gastaut, H2
Tinuper, P2
Aguglia, U3
Lugaresi, E1
Gambardella, A1
Oliveri, RL1
Russo, C1
Zappia, M1
Quattrone, A1

Reviews

3 reviews available for clobazam and Absence Status

ArticleYear
Advancements in the critical care management of status epilepticus.
    Current opinion in critical care, 2017, Volume: 23, Issue:2

    Topics: Acetamides; Administration, Intravenous; Anticonvulsants; Benzodiazepines; Clobazam; Critical Care;

2017
Nonconvulsive status epilepticus in pediatric populations: diagnosis and management.
    Minerva pediatrica, 2012, Volume: 64, Issue:3

    Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Child; Clobazam; Electroencephalography; Humans; Lo

2012
[Benzodiazepines in the treatment of epilepsy].
    L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam

1983

Trials

1 trial available for clobazam and Absence Status

ArticleYear
Corticosteroids versus clobazam in epileptic encephalopathy with ESES: a European multicentre randomised controlled clinical trial (RESCUE ESES*).
    Trials, 2020, Nov-23, Volume: 21, Issue:1

    Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Clobazam; Electroencephalography; Epilepsy; Europe

2020

Other Studies

15 other studies available for clobazam and Absence Status

ArticleYear
A novel de novo TET3 loss-of-function variant in a Turkish boy presenting with neurodevelopmental delay and electrical status epilepticus during slow-wave sleep.
    Brain & development, 2023, Volume: 45, Issue:2

    Topics: Child; Clobazam; Dioxygenases; Electroencephalography; Humans; Infant; Male; Sleep; Sleep, Slow-Wave

2023
Successful use of fenfluramine in nonconvulsive status epilepticus of Dravet syndrome.
    Epilepsia, 2020, Volume: 61, Issue:4

    Topics: Anticonvulsants; Child; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Fenfluramine; Hu

2020
Vaccination management in an asymptomatic child with a novel SCN1A variant and family history of status epilepticus following vaccination: A case report on a potential new direction in personalised medicine.
    Seizure, 2020, Volume: 78

    Topics: Anticonvulsants; Clobazam; Enterovirus A, Human; Enterovirus Infections; Epilepsy; Fatal Outcome; Fe

2020
Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome.
    Epilepsy & behavior : E&B, 2014, Volume: 37

    Topics: Adult; Aged; Anticonvulsants; Anxiety Disorders; Benzodiazepines; Clobazam; Drug-Related Side Effect

2014
Clobazam: An effective add-on therapy in refractory status epilepticus.
    Epilepsia, 2015, Volume: 56, Issue:6

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Electroencephalography;

2015
Effects of clobazam for treatment of refractory status epilepticus.
    BMC neurology, 2016, Oct-21, Volume: 16, Issue:1

    Topics: Aged; Anticonvulsants; Benzodiazepines; Clobazam; Drug Resistant Epilepsy; Female; Humans; Male; Mid

2016
Symptomatic complex partial status epilepticus manifesting as utilization behavior of a mobile phone.
    Epilepsy & behavior : E&B, 2009, Volume: 14, Issue:3

    Topics: Anticonvulsants; Benzodiazepines; Brain Neoplasms; Cell Phone; Clobazam; Electroencephalography; Epi

2009
Non-convulsive status epilepticus and audiogenic seizures complicating a patient with asymmetrical epileptic spasms.
    Brain & development, 2010, Volume: 32, Issue:7

    Topics: Anticonvulsants; Benzodiazepines; Brain; Clobazam; Electroencephalography; Epilepsy, Reflex; Female;

2010
Intranasal clobazam delivery in the treatment of status epilepticus.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:2

    Topics: Administration, Intranasal; Animals; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Drug Stabili

2011
A case of nonconvulsive status epilepticus associated with focal cortical dysplasia.
    Brain & development, 2003, Volume: 25, Issue:3

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain Diseases; Cerebral Cortex; Child; Child

2003
Miconazole and clobazam; a useful interaction in Dravet's syndrome?
    Archives of disease in childhood, 2004, Volume: 89, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Child; Clobazam; Drug Interactions; Drug Therapy, Combination; Fem

2004
The difficulty in diagnosing non-convulsive status epilepticus during routine medical practice.
    Age and ageing, 2004, Volume: 33, Issue:5

    Topics: Aged; Anticonvulsants; Benzodiazepines; Clobazam; Diagnosis, Differential; Emergencies; Humans; Mida

2004
[Treatment of certain forms of status epilepticus by means of a single oral dose of clobazam].
    Revue d'electroencephalographie et de neurophysiologie clinique, 1984, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child;

1984
Negative myoclonic status due to antiepileptic drug tapering: report of three cases.
    Epilepsia, 1997, Volume: 38, Issue:7

    Topics: Adolescent; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cerebral

1997
Use of clobazam in certain forms of status epilepticus and in startle-induced epileptic seizures.
    Epilepsia, 1986, Volume: 27 Suppl 1

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobaz

1986