clobazam has been researched along with Absence Status in 19 studies
Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors administered clobazam (CLB) to treat status epilepticus in 16 patients from 3 to 62 years old." | 7.67 | [Treatment of certain forms of status epilepticus by means of a single oral dose of clobazam]. ( Aguglia, U; Gastaut, H; Lugaresi, E; Tinuper, P, 1984) |
| "Sixteen patients with status epilepticus (SE) and 13 patients suffering from startle-induced epilepsy were treated with clobazam (CLB)." | 7.67 | Use of clobazam in certain forms of status epilepticus and in startle-induced epileptic seizures. ( Aguglia, U; Gastaut, H; Tinuper, P, 1986) |
| "Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties." | 5.43 | Effects of clobazam for treatment of refractory status epilepticus. ( Gerner, ST; Geyer, A; Gollwitzer, S; Hamer, HM; Huttner, HB; Knappe, RU; Kuramatsu, JB; Madžar, D, 2016) |
| "Clobazam was introduced after a median duration of 4 days and after a median of three failed antiepileptic drugs." | 5.42 | Clobazam: An effective add-on therapy in refractory status epilepticus. ( Ibrahim, M; Mohamed, W; Norris, G; Parker, D; Shah, A; Sivakumar, S, 2015) |
| "To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)." | 5.40 | Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014) |
| " However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety." | 5.37 | Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011) |
| " Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy." | 4.76 | [Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983) |
| "The authors administered clobazam (CLB) to treat status epilepticus in 16 patients from 3 to 62 years old." | 3.67 | [Treatment of certain forms of status epilepticus by means of a single oral dose of clobazam]. ( Aguglia, U; Gastaut, H; Lugaresi, E; Tinuper, P, 1984) |
| "Sixteen patients with status epilepticus (SE) and 13 patients suffering from startle-induced epilepsy were treated with clobazam (CLB)." | 3.67 | Use of clobazam in certain forms of status epilepticus and in startle-induced epileptic seizures. ( Aguglia, U; Gastaut, H; Tinuper, P, 1986) |
| "Recent studies support the initial treatment of status epilepticus with early and aggressive benzodiazepine dosing." | 2.55 | Advancements in the critical care management of status epilepticus. ( Bauerschmidt, A; Claassen, J; Martin, A, 2017) |
| "Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties." | 1.43 | Effects of clobazam for treatment of refractory status epilepticus. ( Gerner, ST; Geyer, A; Gollwitzer, S; Hamer, HM; Huttner, HB; Knappe, RU; Kuramatsu, JB; Madžar, D, 2016) |
| "Clobazam was introduced after a median duration of 4 days and after a median of three failed antiepileptic drugs." | 1.42 | Clobazam: An effective add-on therapy in refractory status epilepticus. ( Ibrahim, M; Mohamed, W; Norris, G; Parker, D; Shah, A; Sivakumar, S, 2015) |
| "To assess withdrawal-related adverse event (AE) rates following abrupt clobazam discontinuation in Phase I trials and gradual clobazam tapering (2-3 weeks) following discontinuation from III trials met the criteria for potential/III trials, we evaluated AE data from four multiple-dosage Phase I trials (duration: 8-34 days)." | 1.40 | Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome. ( Bekersky, I; Harris, SI; Isojarvi, J; Lee, D; Tolbert, D, 2014) |
| " However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety." | 1.37 | Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011) |
| "Spasms in series and hypsarrhythmia disappeared after treatment with high-dose phenobarbital; however, single spasms persisted with right-sided predominance, and polyspike activity in the left parieto-temporal areas preceded or coincided with these spasms." | 1.36 | Non-convulsive status epilepticus and audiogenic seizures complicating a patient with asymmetrical epileptic spasms. ( Hoshino, K; Komaki, H; Nakagawa, E; Saito, Y; Sakuma, H; Sasaki, M; Sugai, K, 2010) |
| "Three patients aged 16, 19, and 65 years with a 13- to 36-year history of partial epilepsy were receiving a therapeutic dosage of carbamazepine or phenobarbital plus either clobazam (CLB) or valproate (VPA)." | 1.30 | Negative myoclonic status due to antiepileptic drug tapering: report of three cases. ( Aguglia, U; Gambardella, A; Oliveri, RL; Quattrone, A; Russo, C; Zappia, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Sager, SG | 1 |
| Turkyilmaz, A | 1 |
| Gunbey, HP | 1 |
| Karatoprak, EY | 1 |
| Aslan, ES | 1 |
| Akın, Y | 1 |
| Specchio, N | 1 |
| Pietrafusa, N | 1 |
| Ferretti, A | 1 |
| Trivisano, M | 1 |
| Vigevano, F | 1 |
| Deng, L | 1 |
| Ma, A | 1 |
| Wood, N | 1 |
| Ardern-Holmes, S | 1 |
| van den Munckhof, B | 1 |
| Arzimanoglou, A | 1 |
| Perucca, E | 1 |
| van Teeseling, HC | 1 |
| Leijten, FSS | 1 |
| Braun, KPJ | 1 |
| Jansen, FE | 1 |
| Tolbert, D | 1 |
| Harris, SI | 1 |
| Bekersky, I | 1 |
| Lee, D | 1 |
| Isojarvi, J | 1 |
| Sivakumar, S | 1 |
| Ibrahim, M | 1 |
| Parker, D | 1 |
| Norris, G | 1 |
| Shah, A | 1 |
| Mohamed, W | 1 |
| Madžar, D | 1 |
| Geyer, A | 1 |
| Knappe, RU | 1 |
| Gollwitzer, S | 1 |
| Kuramatsu, JB | 1 |
| Gerner, ST | 1 |
| Hamer, HM | 1 |
| Huttner, HB | 1 |
| Bauerschmidt, A | 1 |
| Martin, A | 1 |
| Claassen, J | 1 |
| Carota, A | 1 |
| Novy, J | 1 |
| Rossetti, AO | 1 |
| Saito, Y | 1 |
| Sugai, K | 1 |
| Nakagawa, E | 1 |
| Sakuma, H | 1 |
| Komaki, H | 1 |
| Sasaki, M | 1 |
| Hoshino, K | 1 |
| Florence, K | 1 |
| Manisha, L | 1 |
| Kumar, BA | 1 |
| Ankur, K | 1 |
| Kumar, MA | 1 |
| Ambikanandan, M | 1 |
| Galimi, R | 1 |
| Yoshimura, K | 1 |
| Goldsmith, J | 1 |
| McKnight, C | 1 |
| Dickson, S | 1 |
| Heenan, M | 1 |
| Berezowski, R | 1 |
| Cooper, J | 1 |
| Feely, M | 1 |
| Loiseau, P | 1 |
| Gastaut, H | 2 |
| Tinuper, P | 2 |
| Aguglia, U | 3 |
| Lugaresi, E | 1 |
| Gambardella, A | 1 |
| Oliveri, RL | 1 |
| Russo, C | 1 |
| Zappia, M | 1 |
| Quattrone, A | 1 |
3 reviews available for clobazam and Absence Status
| Article | Year |
|---|---|
Advancements in the critical care management of status epilepticus.
Topics: Acetamides; Administration, Intravenous; Anticonvulsants; Benzodiazepines; Clobazam; Critical Care; | 2017 |
Nonconvulsive status epilepticus in pediatric populations: diagnosis and management.
Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Child; Clobazam; Electroencephalography; Humans; Lo | 2012 |
[Benzodiazepines in the treatment of epilepsy].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam | 1983 |
1 trial available for clobazam and Absence Status
| Article | Year |
|---|---|
Corticosteroids versus clobazam in epileptic encephalopathy with ESES: a European multicentre randomised controlled clinical trial (RESCUE ESES*).
Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Clobazam; Electroencephalography; Epilepsy; Europe | 2020 |
15 other studies available for clobazam and Absence Status
| Article | Year |
|---|---|
A novel de novo TET3 loss-of-function variant in a Turkish boy presenting with neurodevelopmental delay and electrical status epilepticus during slow-wave sleep.
Topics: Child; Clobazam; Dioxygenases; Electroencephalography; Humans; Infant; Male; Sleep; Sleep, Slow-Wave | 2023 |
Successful use of fenfluramine in nonconvulsive status epilepticus of Dravet syndrome.
Topics: Anticonvulsants; Child; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Fenfluramine; Hu | 2020 |
Vaccination management in an asymptomatic child with a novel SCN1A variant and family history of status epilepticus following vaccination: A case report on a potential new direction in personalised medicine.
Topics: Anticonvulsants; Clobazam; Enterovirus A, Human; Enterovirus Infections; Epilepsy; Fatal Outcome; Fe | 2020 |
Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndrome.
Topics: Adult; Aged; Anticonvulsants; Anxiety Disorders; Benzodiazepines; Clobazam; Drug-Related Side Effect | 2014 |
Clobazam: An effective add-on therapy in refractory status epilepticus.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Electroencephalography; | 2015 |
Effects of clobazam for treatment of refractory status epilepticus.
Topics: Aged; Anticonvulsants; Benzodiazepines; Clobazam; Drug Resistant Epilepsy; Female; Humans; Male; Mid | 2016 |
Symptomatic complex partial status epilepticus manifesting as utilization behavior of a mobile phone.
Topics: Anticonvulsants; Benzodiazepines; Brain Neoplasms; Cell Phone; Clobazam; Electroencephalography; Epi | 2009 |
Non-convulsive status epilepticus and audiogenic seizures complicating a patient with asymmetrical epileptic spasms.
Topics: Anticonvulsants; Benzodiazepines; Brain; Clobazam; Electroencephalography; Epilepsy, Reflex; Female; | 2010 |
Intranasal clobazam delivery in the treatment of status epilepticus.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Drug Stabili | 2011 |
A case of nonconvulsive status epilepticus associated with focal cortical dysplasia.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain Diseases; Cerebral Cortex; Child; Child | 2003 |
Miconazole and clobazam; a useful interaction in Dravet's syndrome?
Topics: Anticonvulsants; Benzodiazepines; Child; Clobazam; Drug Interactions; Drug Therapy, Combination; Fem | 2004 |
The difficulty in diagnosing non-convulsive status epilepticus during routine medical practice.
Topics: Aged; Anticonvulsants; Benzodiazepines; Clobazam; Diagnosis, Differential; Emergencies; Humans; Mida | 2004 |
[Treatment of certain forms of status epilepticus by means of a single oral dose of clobazam].
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; | 1984 |
Negative myoclonic status due to antiepileptic drug tapering: report of three cases.
Topics: Adolescent; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cerebral | 1997 |
Use of clobazam in certain forms of status epilepticus and in startle-induced epileptic seizures.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobaz | 1986 |