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clobazam and Absence Seizure

clobazam has been researched along with Absence Seizure in 84 studies

Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.

Research Excerpts

ExcerptRelevanceReference
"Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration."9.41Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021)
"To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS)."9.19Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years. ( Conry, JA; Drummond, R; Isojarvi, J; Kernitsky, L; Lee, D; Mitchell, WG; Ng, YT; Paolicchi, JM; Veidemanis, R, 2014)
"To determine the safety and efficacy (measured by the incidence of 'treatment failure') of clobazam in comparison to standard treatment with phenytoin-sodium for prevention of seizures in persons with solitary cysticercus granulomas (SCGs)."9.12Safety and efficacy of clobazam versus phenytoin-sodium in the antiepileptic drug treatment of solitary cysticercus granulomas. ( Chopra, SC; Kaushal, S; Rani, A; Singh, G, 2006)
"Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types."9.06Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations. ( Blaschuk, K; Couture, M; Guberman, A; Sherwin, A, 1990)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures."8.98Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures."8.90Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014)
"This retrospective chart review study (GWEP20052) evaluated plant-derived highly purified cannabidiol (CBD; Epidyolex®; 100 mg/mL oral solution) use without clobazam as add-on therapy in patients aged ≥2 years with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) enrolled in a European Early Access Program."8.31Retrospective chart review study of use of cannabidiol (CBD) independent of concomitant clobazam use in patients with Lennox-Gastaut syndrome or Dravet syndrome. ( Arzimanoglou, A; Auvin, S; Berquin, P; Cross, JH; Desurkar, A; Fuller, D; Nabbout, R; Nortvedt, C; Pulitano, P; Rosati, A; Soto, V; Villanueva, V, 2023)
"To prospectively study the effectiveness and safety of clobazam as an add-on therapy in patients with epilepsy whose seizures are not adequately controlled with antiseizure medicine (ASM) monotherapy."8.12Evaluation of one-year effectiveness of clobazam as an add-on therapy to anticonvulsant monotherapy in participants with epilepsy having uncontrolled seizure episodes: An Indian experience. ( Agadi, J; Agarwal, VK; Alagesan, S; Apte, A; Arora, V; Asokan, K; Chauhan, D; Chodankar, D; Garg, S; Gurumukhani, J; Jha, SK; Kumar, A; Lingappa, L; Mandal, A; Menon, B; Padhy, U; Rathore, C; Ravat, S; Razdan, S; Satishchandra, P; Shah, SV; Shetty, S; Sundaracharya, NV; Venkateshwarlu, K; Vk, S, 2022)
" We review the use of short burst Clobazam dosing on discharge from the Epilepsy monitoring unit (EMU) to determine if this might reduce rates of representation with seizures."7.91Short burst Clobazam dosing at discharge from VEEG evaluation reduces re-presentation with seizures. ( Dionisio, S; Gillinder, L; Scarborough, L, 2019)
"This is a prospective study of children with Lennox-Gastaut syndrome receiving clobazam as adjunctive therapy."7.91Evaluation of the Effects of Clobazam on Seizure Control and Quality of Life in Children With Lennox-Gastaut Syndrome: A Pilot Study. ( Agarwal, N; Cheema, Z; Farooq, O; Hamilton, D; Parrish, J; Weinstock, A, 2019)
"A 12-year-old boy with intractable epilepsy had tonic and atonic seizures despite treatment with valproic acid (3000mg/day), levetiracetam (3000mg/day) and clobazam (40mg/day)."7.83Aggravation of atonic seizures by rufinamide: A case report. ( Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B, 2016)
"Clobazam has been used in clinical practice as an adjunctive treatment for diverse seizure types and epilepsy syndromes."7.80Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. ( Bergin, AM; Bolton, J; Bourgeois, B; Harini, C; Kadish, NE; Klehm, J; Libenson, M; Loddenkemper, T; Peters, J; Poduri, A; Rotenberg, A; Sánchez Fernández, I; Takeoka, M; Thome-Souza, S, 2014)
"In addition to reducing convulsive seizure frequency, STP also markedly reduces the number of status epilepticus episodes and associated medical complications which are more common in younger children."7.01Stiripentol for the treatment of seizures associated with Dravet syndrome in patients 6 months and older and taking clobazam. ( Vasquez, A; Wirrell, EC; Youssef, PE, 2023)
" The key outcomes were reduction in seizure frequency, differences in 50% responder rates, adverse events, and interactions with clobazam as co-therapy."7.01Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis. ( Aparasu, R; Estes, E; Reddy, DS; Talwar, A, 2023)
"Here, one such patient became seizure free, allowing us to identify and compare the changes in hippocampal electrophysiology associated with ANT stimulation and seizure freedom."5.91Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography. ( Brandman, DM; Bullinger, K; Gross, RE; Isbaine, F; Skelton, HM, 2023)
"The average number of seizures per month during the previous 3 months before CNB treatment was 19."5.91Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies. ( Aguilar-Castillo, MJ; Cabezudo-García, P; Carreño, M; Ciano-Petersen, NL; Estivill-Torrús, G; García-Martín, G; Gutierrez-Cardo, AL; López-Moreno, Y; Oliver, B; Ortega-Pinazo, J; Ramírez-García, T; Rodríguez-Uranga, JJ; Romero-Godoy, J; Sanchez-Godoy, L; Serrano-Castro, PJ, 2023)
"Several studies suggest antiseizure effects also beyond these three epilepsy syndromes."5.91Real-world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study. ( Bast, T; Becker, LL; Bertsche, A; Borggraefe, I; Boßelmann, CM; De Vries, H; Fahrbach, J; Hertzberg, C; Herz, NA; Hirsch, M; Holtkamp, M; Janello, C; Kaindl, AM; Klotz, KA; Kluger, GJ; Kühne, F; Kurlemann, G; Lerche, H; Makridis, KL; Prager, C; Pringsheim, M; Schubert-Bast, S; Schulz, J; Schulze-Bonhage, A; Steinbart, D; Steinhoff, BJ; Strzelczyk, A; Syrbe, S; von Podewils, F; Wagner, C; Wagner, J; Wilken, B, 2023)
"Clobazam is an effective agent to use as add-on AED in TRE, with 94% of patients showing a significant response within 6 months."5.62Efficacy of clobazam as add-on therapy in brain tumor-related epilepsy. ( Bachman, E; Brahmbhatt, N; Bushara, O; Schuele, SU; Stupp, R; Templer, JW, 2021)
" In the absence of clinical trial data on optimization of AED dosage in patients with LGS, dose titration is guided by personal experience, anecdotal evidence, and specific patient factors (age, comorbid conditions and medications, seizure types, etc."5.48Optimizing clobazam treatment in patients with Lennox-Gastaut syndrome. ( Chung, S; Gidal, BE; Isojarvi, J; Wechsler, RT, 2018)
"Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures."5.48Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center. ( Carson, RP; Carter, EG; Doll, ED; Fu, C; Porcari, GS, 2018)
"Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration."5.41Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021)
"Each baseline seizure-frequency quartile had ~40 patients, and baseline weekly drop-seizure frequency ranges were as follows: <10 (Quartile 1), 10-30 (Quartile 2), 32-86 (Quartile 3), and 86-1077 (Quartile 4)."5.40Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience. ( Benbadis, SR; Drummond, R; Isojarvi, J; Lee, D; Wheless, JW, 2014)
" However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety."5.37Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011)
"These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection."5.28Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992)
"To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS)."5.19Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years. ( Conry, JA; Drummond, R; Isojarvi, J; Kernitsky, L; Lee, D; Mitchell, WG; Ng, YT; Paolicchi, JM; Veidemanis, R, 2014)
"To determine the safety and efficacy (measured by the incidence of 'treatment failure') of clobazam in comparison to standard treatment with phenytoin-sodium for prevention of seizures in persons with solitary cysticercus granulomas (SCGs)."5.12Safety and efficacy of clobazam versus phenytoin-sodium in the antiepileptic drug treatment of solitary cysticercus granulomas. ( Chopra, SC; Kaushal, S; Rani, A; Singh, G, 2006)
"Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types."5.06Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations. ( Blaschuk, K; Couture, M; Guberman, A; Sherwin, A, 1990)
"To evaluate the potential impact of concomitant clobazam (CLB) use on the efficacy of cannabidiol (CBD) treatment in patients with Dravet syndrome and Lennox-Gastaut syndrome using meta-analytical techniques."5.05Cannabidiol efficacy and clobazam status: A systematic review and meta-analysis. ( Brigo, F; Del Giovane, C; Lattanzi, S; Nardone, R; Silvestrini, M; Striano, P; Trinka, E; Zaccara, G, 2020)
"Four pivotal randomized placebo-controlled trials have demonstrated that adjunctive therapy with cannabidiol (CBD) improves seizure control in patients with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS)."5.05Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials. ( Bialer, M; Perucca, E, 2020)
"The efficacy of cannabidiol (CBD) with and without concomitant clobazam (CLB) was evaluated in stratified analyses of four large randomized controlled trials, two in Lennox-Gastaut syndrome, and two in Dravet syndrome."5.05Cannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials. ( Checketts, D; Devinsky, O; Dunayevich, E; Knappertz, V; Morrison, G; Thiele, EA; Wright, S, 2020)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures."4.98Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures."4.90Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014)
"This retrospective chart review study (GWEP20052) evaluated plant-derived highly purified cannabidiol (CBD; Epidyolex®; 100 mg/mL oral solution) use without clobazam as add-on therapy in patients aged ≥2 years with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) enrolled in a European Early Access Program."4.31Retrospective chart review study of use of cannabidiol (CBD) independent of concomitant clobazam use in patients with Lennox-Gastaut syndrome or Dravet syndrome. ( Arzimanoglou, A; Auvin, S; Berquin, P; Cross, JH; Desurkar, A; Fuller, D; Nabbout, R; Nortvedt, C; Pulitano, P; Rosati, A; Soto, V; Villanueva, V, 2023)
" The mean baseline seizure frequency before initiation of clobazam was 2 (range 1-30) seizures per month."4.31Tolerability of clobazam as add-on therapy in patients aged 50 years and older with drug-resistant epilepsy. ( Bunch, ME; Frawley, B; Lynch, TM; Nagarajan, E, 2023)
"To prospectively study the effectiveness and safety of clobazam as an add-on therapy in patients with epilepsy whose seizures are not adequately controlled with antiseizure medicine (ASM) monotherapy."4.12Evaluation of one-year effectiveness of clobazam as an add-on therapy to anticonvulsant monotherapy in participants with epilepsy having uncontrolled seizure episodes: An Indian experience. ( Agadi, J; Agarwal, VK; Alagesan, S; Apte, A; Arora, V; Asokan, K; Chauhan, D; Chodankar, D; Garg, S; Gurumukhani, J; Jha, SK; Kumar, A; Lingappa, L; Mandal, A; Menon, B; Padhy, U; Rathore, C; Ravat, S; Razdan, S; Satishchandra, P; Shah, SV; Shetty, S; Sundaracharya, NV; Venkateshwarlu, K; Vk, S, 2022)
"Clobazam (CLB) is an effective anticonvulsant used as an adjunctive treatment for several seizures and epilepsy syndromes."4.12CLB add-on treatment in patients with epileptic encephalopathy: a single center experience with long-term follow-up. ( Öztürk, G; Türkdoğan, D, 2022)
"Cannabidiol (CBD) has been shown to reduce seizures among patients with refractory epilepsies of various etiologies in recent clinical trials and an expanded access program (EAP)."4.02The long-term efficacy of cannabidiol in the treatment of refractory epilepsy. ( Bruno, PL; Fleming, B; Grinspoon, R; Patel, S; Skirvin, LA; Thiele, EA; Wade, C; Wolper, E, 2021)
"With this study, we aim to test the hypothesis that the effect of cannabidiol on drop-seizure frequency in patients with Lennox-Gastaut syndrome and Dravet syndrome could be attributed to a drug-drug interaction with clobazam."3.96Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop-seizure frequency. ( Bergmann, KR; Broekhuizen, K; Groeneveld, GJ, 2020)
"This is a prospective study of children with Lennox-Gastaut syndrome receiving clobazam as adjunctive therapy."3.91Evaluation of the Effects of Clobazam on Seizure Control and Quality of Life in Children With Lennox-Gastaut Syndrome: A Pilot Study. ( Agarwal, N; Cheema, Z; Farooq, O; Hamilton, D; Parrish, J; Weinstock, A, 2019)
"Clobazam is a commonly used long-acting benzodiazepine approved by the US Food and Drug Administration (FDA) to treat seizures associated with Lennox Gastaut syndrome."3.91Safety and Efficacy of Supratherapeutic Doses of Clobazam. ( Freedman, DA; Gedela, S; Glynn, P; Patel, AD; Salvator, A, 2019)
" We review the use of short burst Clobazam dosing on discharge from the Epilepsy monitoring unit (EMU) to determine if this might reduce rates of representation with seizures."3.91Short burst Clobazam dosing at discharge from VEEG evaluation reduces re-presentation with seizures. ( Dionisio, S; Gillinder, L; Scarborough, L, 2019)
"Clobazam treatment tailored to the timing of patient's seizures may improve seizure control."3.83Clobazam higher-evening differential dosing as an add-on therapy in refractory epilepsy. ( Fernández, IS; Jackson, M; Kadish, NE; Klehm, J; Loddenkemper, T; Manganaro, S; Thome-Souza, S, 2016)
"A 12-year-old boy with intractable epilepsy had tonic and atonic seizures despite treatment with valproic acid (3000mg/day), levetiracetam (3000mg/day) and clobazam (40mg/day)."3.83Aggravation of atonic seizures by rufinamide: A case report. ( Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B, 2016)
"We report the case of an aborted awake craniotomy for a left frontotemporoinsular glioma due to ammonia encephalopathy on a patient taking Levetiracetam, valproic acid and clobazam."3.81Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy. ( Arroyo Pérez, R; Fernández-Candil, JL; León Jorba, A; Pacreu Terradas, S; Villalba Martínez, G; Vivanco-Hidalgo, RM, 2015)
"Clobazam (CLB), a 1,5-benzodiazepine (BZD), was FDA-approved in October 2011 for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years and older."3.80Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes. ( Ebert, B; Jensen, HS; Lee, D; Nichol, K, 2014)
"Clobazam has been used in clinical practice as an adjunctive treatment for diverse seizure types and epilepsy syndromes."3.80Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. ( Bergin, AM; Bolton, J; Bourgeois, B; Harini, C; Kadish, NE; Klehm, J; Libenson, M; Loddenkemper, T; Peters, J; Poduri, A; Rotenberg, A; Sánchez Fernández, I; Takeoka, M; Thome-Souza, S, 2014)
"Stiripentol is an effective and well-tolerated therapy that markedly reduced frequency of prolonged seizures in Dravet syndrome."3.79Stiripentol in Dravet syndrome: results of a retrospective U.S. study. ( Chancharme, L; Chugani, H; de Menezes, MS; Devinsky, O; Franz, DN; Hamiwka, L; Hernandez, A; Laux, L; Le Guern, ME; Mikati, MA; Morse, RP; Saneto, RP; Sullivan, J; Valencia, I; Wirrell, EC, 2013)
" In one approach, mice were chronically treated with either diazepam, clonazepam, clobazam or the novel anxiolytic and anticonvulsant beta-carboline derivative abecarnil for 4 weeks, at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole."3.69Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil. ( Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C, 1996)
"Tolerance to the anticonvulsant effects of clobazam has been studied in three murine models of epilepsy: pentylenetetrazole- and N-methyl-D,L-aspartic acid-induced seizures and audiogenic-induced seizures in the DBA/2 strain."3.68Tolerance to the anticonvulsant effects of clobazam in mice. ( Pleuvry, BJ; Wildin, JD, 1992)
"Preliminary studies of patients who had brain damage, intractable epilepsy, and mental subnormality showed that clobazam in small doses (20 to 30 mg/day) was beneficial, and indicated that a more detailed investigation was worthwhile."3.67On the anticonvulsant and psychotropic properties of clobazam--a preliminary study. ( Moffett, A; Scott, DF, 1986)
"Epidiolex® (CBD) is FDA-approved for seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and tuberous sclerosis complex (TSC)."3.30Real-world, long-term evaluation of the tolerability and therapy retention of Epidiolex® (cannabidiol) in patients with refractory epilepsy. ( Felton, E; Georgieva, D; Gidal, BE; Hartkopf, K; Hawk, L; Hsu, D; Langley, J; Margolis, A; Struck, A, 2023)
" The key outcomes were reduction in seizure frequency, differences in 50% responder rates, adverse events, and interactions with clobazam as co-therapy."3.01Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis. ( Aparasu, R; Estes, E; Reddy, DS; Talwar, A, 2023)
"In addition to reducing convulsive seizure frequency, STP also markedly reduces the number of status epilepticus episodes and associated medical complications which are more common in younger children."3.01Stiripentol for the treatment of seizures associated with Dravet syndrome in patients 6 months and older and taking clobazam. ( Vasquez, A; Wirrell, EC; Youssef, PE, 2023)
" ≥50% reduction in drop seizure frequency from baseline and occurrence of treatment-emergent adverse events (TEAEs) were the primary efficacy and safety outcomes."2.82Short-term and long-term efficacy and safety of antiseizure medications in Lennox Gastaut syndrome: A network meta-analysis. ( Ameen, R; Bansal, D; Devi, N; Madaan, P; Sahu, JK, 2022)
"Clobazam (CLB) is a new antiepileptic drug that is the first 1,5-benzodiazepine (BZP) having nitrogen atoms in the 1 and 5 positions of the heterocyclic ring, whose chemical structure was designed to give it a different pharmacological profile from that of 1,4-BZPs."2.41[A pharmacological profile of clobazam (Mystan), a new antiepileptic drug]. ( Nakajima, H, 2001)
"Several studies suggest antiseizure effects also beyond these three epilepsy syndromes."1.91Real-world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study. ( Bast, T; Becker, LL; Bertsche, A; Borggraefe, I; Boßelmann, CM; De Vries, H; Fahrbach, J; Hertzberg, C; Herz, NA; Hirsch, M; Holtkamp, M; Janello, C; Kaindl, AM; Klotz, KA; Kluger, GJ; Kühne, F; Kurlemann, G; Lerche, H; Makridis, KL; Prager, C; Pringsheim, M; Schubert-Bast, S; Schulz, J; Schulze-Bonhage, A; Steinbart, D; Steinhoff, BJ; Strzelczyk, A; Syrbe, S; von Podewils, F; Wagner, C; Wagner, J; Wilken, B, 2023)
"Cenobamate is an antiseizure medication (ASM) approved for the treatment of partial-onset seizures in adults."1.91A retrospective non-interventional study evaluating the pharmacokinetic interactions between cenobamate and clobazam. ( Bien, CG; Brandt, C; Elakkary, S; Hagemann, A; Klimpel, D, 2023)
" To support the use of cenobamate monotherapy, this pharmacokinetic (PK)-based simulation analysis evaluated the predicted PK exposure of cenobamate when used as monotherapy versus adjunctive therapy."1.91Pharmacokinetics of cenobamate as monotherapy compared with adjunctive therapy. ( Ferrari, L; Kamin, M; Rosenfeld, WE; Vashi, V, 2023)
"The average number of seizures per month during the previous 3 months before CNB treatment was 19."1.91Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies. ( Aguilar-Castillo, MJ; Cabezudo-García, P; Carreño, M; Ciano-Petersen, NL; Estivill-Torrús, G; García-Martín, G; Gutierrez-Cardo, AL; López-Moreno, Y; Oliver, B; Ortega-Pinazo, J; Ramírez-García, T; Rodríguez-Uranga, JJ; Romero-Godoy, J; Sanchez-Godoy, L; Serrano-Castro, PJ, 2023)
"Here, one such patient became seizure free, allowing us to identify and compare the changes in hippocampal electrophysiology associated with ANT stimulation and seizure freedom."1.91Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography. ( Brandman, DM; Bullinger, K; Gross, RE; Isbaine, F; Skelton, HM, 2023)
"A positive response (seizure-free and >50 % seizure reduction) was determined for focal-onset (62."1.72The effectiveness and tolerability of clobazam in the pediatric population: Adjunctive therapy and monotherapy in a large-cohort multicenter study. ( Arslan, EA; Aydın, K; Cansu, A; Çarman, KB; Dilber, B; Dündar, NO; Durgut, BD; Erdoğan, I; Gencpinar, P; Hız, SA; Kamaşak, T; Kılıç, BA; Okuyaz, Ç; Özen, N; Özkan Kart, P; Polat, BG; Şahin, S; Serdaroğlu, A; Serdaroğlu, E; Serin, HM; Tekgül, H; Topçu, Y; Yıldız, N; Yılmaz, Ö; Yücel Şen, AD, 2022)
" VPA showed a relatively short half-life in both mice and rats, which correlated with a sharp decline in efficacy."1.72Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach. ( Johnson, K; Mensah, JA; Metcalf, CS; Reilly, CA; Rower, JE; Wilcox, KS, 2022)
"Evidence for treating seizures in AS mainly derives from low-quality studies."1.72Pharmacotherapeutic management of seizures in patients with Angleman Syndrome. ( Samanta, D, 2022)
"Clobazam is an effective agent to use as add-on AED in TRE, with 94% of patients showing a significant response within 6 months."1.62Efficacy of clobazam as add-on therapy in brain tumor-related epilepsy. ( Bachman, E; Brahmbhatt, N; Bushara, O; Schuele, SU; Stupp, R; Templer, JW, 2021)
"Mean reduction in weekly seizure frequency was greater at the best point of seizure control within the first year than at two months of treatment with CBD, regardless of concomitant CLB usage (all p > 0."1.56Efficacy of cannabidiol in subjects with refractory epilepsy relative to concomitant use of clobazam. ( Anagnos, CJ; Bruno, PL; Savage, TE; Skirvin, LA; Sourbron, J; Thiele, EA; Wolper, ES, 2020)
"Seizures are present in over 90% of infants and children with Wolf-Hirschhorn syndrome (WHS)."1.48A survey of antiepileptic drug responses identifies drugs with potential efficacy for seizure control in Wolf-Hirschhorn syndrome. ( Battaglia, A; Carey, JC; Ho, KS; Lortz, A; Markham, LM; Newcomb, T; Olson, LM; Sheng, X; Twede, H; Wassman, ER; Weng, C, 2018)
"Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures."1.48Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center. ( Carson, RP; Carter, EG; Doll, ED; Fu, C; Porcari, GS, 2018)
" In the absence of clinical trial data on optimization of AED dosage in patients with LGS, dose titration is guided by personal experience, anecdotal evidence, and specific patient factors (age, comorbid conditions and medications, seizure types, etc."1.48Optimizing clobazam treatment in patients with Lennox-Gastaut syndrome. ( Chung, S; Gidal, BE; Isojarvi, J; Wechsler, RT, 2018)
"In addition, the effect on seizure count was compared with that of various AED regimen and the vagus nerve stimulation (VNS)."1.42Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen. ( Benninger, F; Dressler, A; Feucht, M; Grassl, R; Gröppel, G; Mühlebner, A; Reiter-Fink, E; Reithofer, E; Trimmel-Schwahofer, P, 2015)
"The seizures were easily controlled with valproate and clobazam."1.40Neck myoclonia with absence seizures in an Indian girl. ( Aneja, S; Jain, P; Sharma, S, 2014)
"The anticonvulsant interaction profile between 1-MeTHIQ and CLB in the mouse MES model was determined using an isobolographic analysis for parallel dose-response relationship curves."1.40Additive interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and clobazam in the mouse maximal electroshock-induced tonic seizure model--an isobolographic analysis for parallel dose-response relationship curves. ( Andres-Mach, M; Haratym-Maj, A; Luszczki, JJ; Zagaja, M, 2014)
"Each baseline seizure-frequency quartile had ~40 patients, and baseline weekly drop-seizure frequency ranges were as follows: <10 (Quartile 1), 10-30 (Quartile 2), 32-86 (Quartile 3), and 86-1077 (Quartile 4)."1.40Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience. ( Benbadis, SR; Drummond, R; Isojarvi, J; Lee, D; Wheless, JW, 2014)
" However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety."1.37Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011)
"The aim of this study was to characterize the anticonvulsant effects of stiripentol (STP) in combination with clobazam [CLB], and valproate [VPA]) in the mouse maximal electroshock (MES)-induced seizure model using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs)."1.36Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Trojnar, MK, 2010)
"Minimal, predominantly clonic seizures with preserved righting ability were reliably induced by pentylenetetrazol and suppressed by clobazam in rats aged 18 days or more."1.30Antipentylenetetrazol action of clobazam in developing rats. ( Haugvicová, R; Kubová, H; Mares, P, 1999)
"These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection."1.28Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992)
"The electrocardiogram showed a right bundle branch block and a left anterior hemiblock over 72 h."1.28[Maprotiline poisoning in an eleven-month-old infant]. ( Bétremieux, P; Breurec, JY; Dabadie, A; Durand, C; Lefrançois, C; Roussey, M, 1990)
"Three personal observations of "eating seizures' are described and similar cases in the literature considered."1.27Eating seizures. ( Aguglia, U; Tinuper, P, 1983)
"Maximal seizures were induced by electroshock (MES) and the chemical convulsants pentetrazol (PTZ), picrotoxin (PTX), bicuculline (BIC), isoniazid (INH), nicotine (NIC) and strychnine (STR)."1.27Etifoxine: evaluation of its anticonvulsant profile in mice in comparison with sodium valproate, phenytoin and clobazam. ( Kruse, HJ; Kuch, H, 1985)
"Tonic-clonic (maximal) seizures were induced by maximal electroshock (MES; 12 mA, 200 ms) and clonic (threshold) seizures by pentetrazol (PTZ; 85 mg/kg s."1.27Potentiation of clobazam's anticonvulsant activity by etifoxine, a non-benzodiazepine tranquilizer, in mice. Comparison studies with sodium valproate. ( Kruse, HJ; Kuch, H, 1986)
"Clobazam is a new benzodiazepine recently introduced in Canada on an experimental basis."1.27Clobazam for refractory childhood seizure disorders--a valuable supplementary drug. ( Camfield, C; Camfield, P; Dooley, J; Munn, R, 1988)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19907 (8.33)18.7374
1990's13 (15.48)18.2507
2000's8 (9.52)29.6817
2010's31 (36.90)24.3611
2020's25 (29.76)2.80

Authors

AuthorsStudies
Yogeeswari, P1
Sriram, D1
Thirumurugan, R1
Raghavendran, JV1
Sudhan, K1
Pavana, RK1
Stables, J1
Rajak, H1
Singh Thakur, B1
Singh, A1
Raghuvanshi, K1
Sah, AK1
Veerasamy, R1
Sharma, PC1
Singh Pawar, R1
Kharya, MD1
Malik, S1
Bahare, RS1
Khan, SA1
Satishchandra, P1
Rathore, C1
Apte, A1
Kumar, A1
Mandal, A1
Chauhan, D1
Agadi, J1
Gurumukhani, J1
Asokan, K1
Venkateshwarlu, K1
Lingappa, L1
Sundaracharya, NV1
Jha, SK1
Ravat, S1
Vk, S1
Garg, S1
Shah, SV1
Alagesan, S1
Razdan, S1
Padhy, U1
Agarwal, VK1
Arora, V1
Menon, B1
Shetty, S1
Chodankar, D1
Devi, N1
Madaan, P1
Ameen, R1
Sahu, JK1
Bansal, D1
Kamaşak, T1
Serdaroğlu, E1
Yılmaz, Ö1
Kılıç, BA1
Polat, BG1
Erdoğan, I1
Yücel Şen, AD1
Özen, N1
Durgut, BD1
Yıldız, N1
Özkan Kart, P1
Dilber, B1
Arslan, EA1
Şahin, S1
Topçu, Y1
Gencpinar, P1
Serin, HM1
Hız, SA1
Çarman, KB1
Dündar, NO1
Okuyaz, Ç1
Aydın, K1
Serdaroğlu, A1
Tekgül, H1
Cansu, A1
Samanta, D1
Mensah, JA1
Johnson, K1
Reilly, CA1
Wilcox, KS1
Rower, JE1
Metcalf, CS1
Talwar, A1
Estes, E1
Aparasu, R1
Reddy, DS1
Elakkary, S1
Hagemann, A1
Klimpel, D1
Bien, CG1
Brandt, C1
Kühne, F1
Becker, LL1
Bast, T2
Bertsche, A1
Borggraefe, I1
Boßelmann, CM1
Fahrbach, J1
Hertzberg, C1
Herz, NA1
Hirsch, M1
Holtkamp, M1
Janello, C1
Kluger, GJ1
Kurlemann, G2
Lerche, H1
Makridis, KL1
von Podewils, F1
Pringsheim, M1
Schubert-Bast, S2
Schulz, J1
Schulze-Bonhage, A1
Steinbart, D1
Steinhoff, BJ1
Strzelczyk, A2
Syrbe, S1
De Vries, H1
Wagner, C1
Wagner, J1
Wilken, B1
Prager, C1
Klotz, KA1
Kaindl, AM1
Georgieva, D1
Langley, J1
Hartkopf, K1
Hawk, L1
Margolis, A1
Struck, A1
Felton, E1
Hsu, D1
Gidal, BE2
Nagarajan, E1
Lynch, TM1
Frawley, B1
Bunch, ME1
Vasquez, A1
Wirrell, EC2
Youssef, PE1
Nabbout, R1
Arzimanoglou, A1
Auvin, S1
Berquin, P1
Desurkar, A1
Fuller, D1
Nortvedt, C1
Pulitano, P1
Rosati, A1
Soto, V1
Villanueva, V1
Cross, JH1
Vashi, V1
Rosenfeld, WE1
Ferrari, L1
Kamin, M1
Serrano-Castro, PJ1
Rodríguez-Uranga, JJ1
Cabezudo-García, P1
García-Martín, G1
Romero-Godoy, J1
Estivill-Torrús, G1
Ciano-Petersen, NL1
Oliver, B1
Ortega-Pinazo, J1
López-Moreno, Y1
Aguilar-Castillo, MJ1
Gutierrez-Cardo, AL1
Ramírez-García, T1
Sanchez-Godoy, L1
Carreño, M1
Skelton, HM1
Brandman, DM1
Bullinger, K1
Isbaine, F1
Gross, RE1
Bergmann, KR1
Broekhuizen, K1
Groeneveld, GJ1
Savage, TE1
Sourbron, J1
Bruno, PL2
Skirvin, LA2
Wolper, ES1
Anagnos, CJ1
Thiele, EA3
Mandelbaum, DE1
Lattanzi, S1
Trinka, E1
Striano, P1
Zaccara, G1
Del Giovane, C1
Nardone, R1
Silvestrini, M1
Brigo, F1
Bialer, M1
Perucca, E1
Devinsky, O2
Wright, S1
Checketts, D1
Morrison, G1
Dunayevich, E1
Knappertz, V1
Brahmbhatt, N1
Stupp, R1
Bushara, O1
Bachman, E1
Schuele, SU1
Templer, JW1
Türkdoğan, D1
Öztürk, G1
Segal, EB1
Tarquinio, D1
Miller, I1
Wheless, JW2
Dlugos, D1
Biton, V1
Cascino, GD1
Desai, J1
Hogan, RE1
Liow, K1
Sperling, MR1
Vazquez, B1
Cook, DF1
Rabinowicz, AL1
Carrazana, E1
Patel, S1
Grinspoon, R1
Fleming, B1
Wade, C1
Wolper, E1
Isojarvi, J3
Chung, S1
Wechsler, RT1
Porcari, GS1
Fu, C1
Doll, ED1
Carter, EG1
Carson, RP1
Ho, KS1
Markham, LM1
Twede, H1
Lortz, A1
Olson, LM1
Sheng, X1
Weng, C1
Wassman, ER2
Newcomb, T1
Carey, JC1
Battaglia, A1
Arya, R2
Giridharan, N1
Anand, V2
Garg, SK2
Citraro, R1
De Sarro, C1
Leo, A1
Donato di Paola, E1
Palma, E1
Russo, E1
De Sarro, G1
Gillinder, L1
Scarborough, L1
Dionisio, S1
Weinstock, A1
Agarwal, N1
Farooq, O1
Cheema, Z1
Hamilton, D1
Parrish, J1
Gedela, S2
Freedman, DA1
Glynn, P1
Salvator, A1
Patel, AD1
Wolff, M1
Wiemer-Kruel, A1
von Spiczak, S1
Trollmann, R1
Reif, PS1
Pritchard, C1
Polster, T1
Neubauer, BA1
Mayer, T1
Macdonald, D1
Kluger, G1
Klein, KM1
Kieslich, M1
Kay, L1
Kalski, M1
Irwin, J1
Herting, A1
Carroll, J1
Bettendorf, U1
Rosenow, F1
Besag, FMC1
Vasey, MJ1
Tayah, T1
Savard, M1
Desbiens, R1
Nguyen, DK1
Laux, L1
Franz, DN1
Sullivan, J1
Saneto, RP1
Morse, RP1
Chugani, H1
Hernandez, A1
Hamiwka, L1
Mikati, MA1
Valencia, I1
Le Guern, ME1
Chancharme, L1
de Menezes, MS1
Jensen, HS1
Nichol, K1
Lee, D3
Ebert, B1
Jain, P1
Sharma, S1
Aneja, S1
Conry, JA1
Ng, YT1
Kernitsky, L1
Mitchell, WG1
Veidemanis, R1
Drummond, R2
Paolicchi, JM1
Klehm, J2
Thome-Souza, S2
Sánchez Fernández, I1
Bergin, AM1
Bolton, J1
Harini, C1
Kadish, NE2
Libenson, M1
Peters, J1
Poduri, A1
Rotenberg, A1
Takeoka, M1
Bourgeois, B2
Loddenkemper, T2
Andres-Mach, M1
Haratym-Maj, A1
Zagaja, M3
Luszczki, JJ4
Michael, BD1
Benbadis, SR1
Florek-Luszczki, M2
Villalba Martínez, G1
Fernández-Candil, JL1
Vivanco-Hidalgo, RM1
Pacreu Terradas, S1
León Jorba, A1
Arroyo Pérez, R1
Dressler, A1
Trimmel-Schwahofer, P1
Reithofer, E1
Mühlebner, A1
Gröppel, G1
Reiter-Fink, E1
Benninger, F1
Grassl, R1
Feucht, M1
Bektaş, G1
Çalışkan, M1
Aydın, A1
Pembegül Yıldız, E1
Tatlı, B1
Aydınlı, N1
Özmen, M1
Jackson, M1
Manganaro, S1
Fernández, IS1
Hawkins, NA1
Zachwieja, NJ1
Miller, AR1
Anderson, LL1
Kearney, JA1
Ertam, I1
Sezgin, AO1
Unal, I1
Trojnar, MK1
Ratnaraj, N1
Patsalos, PN1
Czuczwar, SJ1
Florence, K1
Manisha, L1
Kumar, BA1
Ankur, K1
Kumar, MA1
Ambikanandan, M1
Cao, D1
Ohtani, H1
Ogiwara, I1
Ohtani, S1
Takahashi, Y1
Yamakawa, K1
Inoue, Y1
Veggiotti, P1
Termine, C1
Granocchio, E1
Bova, S1
Papalia, G1
Lanzi, G1
Goldsmith, J1
McKnight, C1
Dickson, S1
Heenan, M1
Berezowski, R1
Marsden, D1
Libretto, SE1
Kaushal, S1
Rani, A1
Chopra, SC1
Singh, G1
Kulkarni, S1
Hegde, A1
Shah, KN1
Haigh, JR1
Gent, JP1
Calvert, R1
Shenoy, AK1
Miyahara, JT1
Swinyard, EA1
Kupferberg, HJ1
Aguglia, U1
Tinuper, P1
Schwarer, AP1
Opat, SS1
Watson, AL1
Cole-Sinclair, MF1
Caramaschi, P1
Biasi, D1
Carletto, A1
Manzo, T1
Bambara, LM1
Chimirri, A1
Gitto, R1
Grasso, S1
Zappalà, M1
De Sarro, A1
Battista De Sarro, G1
Löscher, W1
Rundfeldt, C1
Hönack, D1
Ebert, U1
Haugvicová, R1
Kubová, H1
Mares, P1
Nakajima, H1
Terra, VC1
Garcia-Cairasco, N1
Wildin, JD1
Pleuvry, BJ1
Tietz, EI1
Bétremieux, P1
Durand, C1
Lefrançois, C1
Roussey, M1
Breurec, JY1
Dabadie, A1
Zifkin, B1
Sherwin, A2
Andermann, F1
Kassahun, K1
Farrell, K1
Zheng, JJ1
Abbott, F1
Guberman, A1
Couture, M1
Blaschuk, K1
Kruse, HJ2
Kuch, H2
Munn, R1
Camfield, P1
Camfield, C1
Dooley, J1
Scott, DF1
Moffett, A1

Reviews

12 reviews available for clobazam and Absence Seizure

ArticleYear
Short-term and long-term efficacy and safety of antiseizure medications in Lennox Gastaut syndrome: A network meta-analysis.
    Seizure, 2022, Volume: 99

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Humans; Lennox Gastaut Syndrome; Network Meta-Analysis; Rand

2022
Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis.
    Experimental neurology, 2023, Volume: 359

    Topics: Adult; Anticonvulsants; Cannabidiol; Child; Clobazam; Drug Resistant Epilepsy; Epilepsies, Myoclonic

2023
Stiripentol for the treatment of seizures associated with Dravet syndrome in patients 6 months and older and taking clobazam.
    Expert review of neurotherapeutics, 2023, Volume: 23, Issue:4

    Topics: Anticonvulsants; Child; Child, Preschool; Clobazam; Epilepsies, Myoclonic; Humans; Observational Stu

2023
Cannabidiol efficacy and clobazam status: A systematic review and meta-analysis.
    Epilepsia, 2020, Volume: 61, Issue:6

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Le

2020
Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials.
    Epilepsia, 2020, Volume: 61, Issue:6

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Interactions; Drug Therapy, Combination; Epilepsies, My

2020
Cannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials.
    Acta neurologica Scandinavica, 2020, Volume: 142, Issue:6

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Le

2020
Clobazam monotherapy for focal or generalized seizures.
    The Cochrane database of systematic reviews, 2018, 07-11, Volume: 7

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par

2018
Seizure management and prescription patterns of anticonvulsants in Dravet syndrome: A multicenter cohort study from Germany and review of literature.
    Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A

    Topics: Anticonvulsants; Clobazam; Cohort Studies; Drug Prescriptions; Drug Therapy, Combination; Epilepsies

2019
An evaluation of clobazam tablets and film (AQST-120) for the treatment of Lennox-Gastaut syndrome.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:13

    Topics: Anticonvulsants; Clobazam; Drug Tolerance; Humans; Lennox Gastaut Syndrome; Randomized Controlled Tr

2019
Clobazam monotherapy for partial-onset or generalized-onset seizures.
    The Cochrane database of systematic reviews, 2014, Oct-04, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par

2014
Clinical use of drugs useful in the treatment of atonic seizures.
    Advances in neurology, 1995, Volume: 67

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera

1995
[A pharmacological profile of clobazam (Mystan), a new antiepileptic drug].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Clinical Trials as Topic; Clobazam;

2001

Trials

7 trials available for clobazam and Absence Seizure

ArticleYear
Real-world, long-term evaluation of the tolerability and therapy retention of Epidiolex® (cannabidiol) in patients with refractory epilepsy.
    Epilepsy & behavior : E&B, 2023, Volume: 141

    Topics: Adolescent; Adult; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clobazam; Drug Resistant E

2023
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.
    Epilepsia, 2021, Volume: 62, Issue:6

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Diazepam; Dru

2021
Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years.
    Epilepsia, 2014, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Female; Huma

2014
Long-term neuropsychological follow-up and nosological considerations in five patients with continuous spikes and waves during slow sleep.
    Epileptic disorders : international epilepsy journal with videotape, 2002, Volume: 4, Issue:4

    Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Pr

2002
Safety and efficacy of clobazam versus phenytoin-sodium in the antiepileptic drug treatment of solitary cysticercus granulomas.
    Neurology India, 2006, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Double-Blind

2006
Clobazam for seizure prophylaxis during busulfan chemotherapy.
    Lancet (London, England), 1995, Nov-04, Volume: 346, Issue:8984

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antineoplastic Agents, Alkylating; Benzodiazepines; B

1995
Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1990, Volume: 17, Issue:3

    Topics: Adult; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Dos

1990

Other Studies

65 other studies available for clobazam and Absence Seizure

ArticleYear
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
    Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver

2005
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity.
    Bioorganic & medicinal chemistry letters, 2013, Feb-01, Volume: 23, Issue:3

    Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Binding Sites; Cyclohexenes; Disease Models, Animal;

2013
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
    European journal of medicinal chemistry, 2013, Volume: 67

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models,

2013
Evaluation of one-year effectiveness of clobazam as an add-on therapy to anticonvulsant monotherapy in participants with epilepsy having uncontrolled seizure episodes: An Indian experience.
    Epilepsy & behavior : E&B, 2022, Volume: 130

    Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Epilepsy; Humans; Male; Prospective Studies; Seiz

2022
The effectiveness and tolerability of clobazam in the pediatric population: Adjunctive therapy and monotherapy in a large-cohort multicenter study.
    Epilepsy research, 2022, Volume: 184

    Topics: Anticonvulsants; Child; Clobazam; Cohort Studies; Epilepsy; Humans; Retrospective Studies; Seizures;

2022
Pharmacotherapeutic management of seizures in patients with Angleman Syndrome.
    Expert opinion on pharmacotherapy, 2022, Volume: 23, Issue:13

    Topics: Anticonvulsants; Cannabidiol; Child; Clobazam; Clonazepam; Ethosuximide; Humans; Lamotrigine; Leveti

2022
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach.
    Epilepsia, 2022, Volume: 63, Issue:11

    Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Epilepsy; Levetiracetam; Male; M

2022
A retrospective non-interventional study evaluating the pharmacokinetic interactions between cenobamate and clobazam.
    Epilepsia, 2023, Volume: 64, Issue:4

    Topics: Adult; Anticonvulsants; Carbamates; Clobazam; Humans; Retrospective Studies; Seizures

2023
Real-world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study.
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Cannabidiol; Child; Clobazam; Drug-Related Side Effects an

2023
Tolerability of clobazam as add-on therapy in patients aged 50 years and older with drug-resistant epilepsy.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023, Volume: 44, Issue:8

    Topics: Aged; Anticonvulsants; Benzodiazepines; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Combination

2023
Retrospective chart review study of use of cannabidiol (CBD) independent of concomitant clobazam use in patients with Lennox-Gastaut syndrome or Dravet syndrome.
    Seizure, 2023, Volume: 110

    Topics: Adolescent; Anticonvulsants; Cannabidiol; Clobazam; Epilepsies, Myoclonic; Humans; Lennox Gastaut Sy

2023
Pharmacokinetics of cenobamate as monotherapy compared with adjunctive therapy.
    Epilepsy research, 2023, Volume: 195

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Humans; Seizures

2023
Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies.
    Neurology(R) neuroimmunology & neuroinflammation, 2023, Volume: 10, Issue:6

    Topics: Clobazam; Drug Resistant Epilepsy; Epilepsy; gamma-Aminobutyric Acid; Humans; Precision Medicine; Pr

2023
Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography.
    Stereotactic and functional neurosurgery, 2023, Volume: 101, Issue:6

    Topics: Biomarkers; Clobazam; Deep Brain Stimulation; Drug Resistant Epilepsy; Electrocorticography; Epileps

2023
Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop-seizure frequency.
    British journal of clinical pharmacology, 2020, Volume: 86, Issue:2

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Humans; Lennox Gastaut Syndrome; Seizures

2020
Efficacy of cannabidiol in subjects with refractory epilepsy relative to concomitant use of clobazam.
    Epilepsy research, 2020, Volume: 160

    Topics: Adolescent; Adult; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clobazam; Drug Resistant E

2020
Re: Efficacy of Cannabidiol in Subjects with Refractory Epilepsy Relative to Concomitant Use of Clobazam.
    Epilepsy research, 2022, Volume: 180

    Topics: Anticonvulsants; Benzodiazepines; Cannabidiol; Clobazam; Drug Resistant Epilepsy; Humans; Seizures

2022
Efficacy of clobazam as add-on therapy in brain tumor-related epilepsy.
    Journal of neuro-oncology, 2021, Volume: 151, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Clobazam; Drug Therapy, Combination; Epilepsy; Female

2021
CLB add-on treatment in patients with epileptic encephalopathy: a single center experience with long-term follow-up.
    Acta neurologica Belgica, 2022, Volume: 122, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clobazam; Drug Therapy, Combination; Epilepsie

2022
The long-term efficacy of cannabidiol in the treatment of refractory epilepsy.
    Epilepsia, 2021, Volume: 62, Issue:7

    Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relations

2021
Optimizing clobazam treatment in patients with Lennox-Gastaut syndrome.
    Epilepsy & behavior : E&B, 2018, Volume: 78

    Topics: Adolescent; Adult; Anticonvulsants; Child; Clobazam; Diagnostic Tests, Routine; Female; Humans; Lenn

2018
Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center.
    Epilepsy & behavior : E&B, 2018, Volume: 80

    Topics: Adolescent; Anticonvulsants; Attention; Cannabidiol; Cannabis; Child; Child, Preschool; Clobazam; Dr

2018
A survey of antiepileptic drug responses identifies drugs with potential efficacy for seizure control in Wolf-Hirschhorn syndrome.
    Epilepsy & behavior : E&B, 2018, Volume: 81

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clobazam; Female; Humans

2018
Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats.
    Epilepsy research, 2018, Volume: 146

    Topics: Acoustic Stimulation; Administration, Oral; Animals; Anticonvulsants; Brain; Clobazam; Dose-Response

2018
Short burst Clobazam dosing at discharge from VEEG evaluation reduces re-presentation with seizures.
    Seizure, 2019, Volume: 67

    Topics: Adult; Anticonvulsants; Clobazam; Electroencephalography; Epilepsy; Humans; Patient Discharge; Retro

2019
Evaluation of the Effects of Clobazam on Seizure Control and Quality of Life in Children With Lennox-Gastaut Syndrome: A Pilot Study.
    Journal of child neurology, 2019, Volume: 34, Issue:8

    Topics: Anticonvulsants; Child; Child, Preschool; Clobazam; Female; Humans; Lennox Gastaut Syndrome; Male; P

2019
Safety and Efficacy of Supratherapeutic Doses of Clobazam.
    Journal of child neurology, 2019, Volume: 34, Issue:12

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Fe

2019
Ictal bradycardia and asystole in an adult with a focal left insular lesion.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:9

    Topics: Anticonvulsants; Benzodiazepines; Bradycardia; Brain Diseases; Cerebral Cortex; Clobazam; Drug Resis

2013
Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
    Epilepsia, 2013, Volume: 54, Issue:9

    Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Therapy, Combi

2013
Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Allosteric Site; Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Brain; Clobazam; Clonazep

2014
Neck myoclonia with absence seizures in an Indian girl.
    Journal of child neurology, 2014, Volume: 29, Issue:11

    Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Electroencephalography; Epilepsies, Myoclo

2014
Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy.
    Pediatric neurology, 2014, Volume: 51, Issue:1

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dose-Response Relat

2014
Additive interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and clobazam in the mouse maximal electroshock-induced tonic seizure model--an isobolographic analysis for parallel dose-response relationship curves.
    Pharmacology, 2014, Volume: 93, Issue:3-4

    Topics: Animals; Anticonvulsants; Benzodiazepines; Clobazam; Disease Models, Animal; Dose-Response Relations

2014
Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience.
    Epilepsy & behavior : E&B, 2014, Volume: 41

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clinical Trials, Phase

2014
Influence of WIN 55,212-2 on the anticonvulsant and acute neurotoxic potential of clobazam and lacosamide in the maximal electroshock-induced seizure model and chimney test in mice.
    Epilepsy research, 2014, Volume: 108, Issue:10

    Topics: Acetamides; Animals; Anticonvulsants; Benzodiazepines; Benzoxazines; Clobazam; Disease Models, Anima

2014
Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy.
    Revista espanola de anestesiologia y reanimacion, 2015, Volume: 62, Issue:5

    Topics: Anesthesia, General; Anesthesia, Local; Anticonvulsants; Aphasia; Benzodiazepines; Brain Diseases; B

2015
Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen.
    Epilepsy research, 2015, Volume: 109

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Bromides; Child; Child, Preschool; Clobazam; Diet, Ket

2015
Influence of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the anticonvulsant and acute side-effect potentials of clobazam, lacosamide, and pregabalin in the maximal electroshock-induced seizure model and chimney test i
    Fundamental & clinical pharmacology, 2015, Volume: 29, Issue:4

    Topics: Acetamides; Animals; Anticonvulsants; Arachidonic Acids; Ataxia; Benzodiazepines; Brain; Clobazam; D

2015
Aggravation of atonic seizures by rufinamide: A case report.
    Brain & development, 2016, Volume: 38, Issue:7

    Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Com

2016
Clobazam higher-evening differential dosing as an add-on therapy in refractory epilepsy.
    Seizure, 2016, Volume: 40

    Topics: Anticonvulsants; Benzodiazepines; Case-Control Studies; Child; Child, Preschool; Clobazam; Drug Chro

2016
Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq.
    PLoS genetics, 2016, Volume: 12, Issue:10

    Topics: Animals; Benzodiazepines; Chromosome Mapping; Chromosomes; Clobazam; Disease Models, Animal; Epileps

2016
A case with Stevens Johnson syndrome triggered by combination of clobazam, lamotrigine, and valproic acid treatment.
    International journal of dermatology, 2009, Volume: 48, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Drug Therapy, Combination; Follow-Up S

2009
Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model.
    Epilepsy research, 2010, Volume: 90, Issue:3

    Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Benzodiazepine

2010
Intranasal clobazam delivery in the treatment of status epilepticus.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:2

    Topics: Administration, Intranasal; Animals; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Drug Stabili

2011
Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome.
    Epilepsia, 2012, Volume: 53, Issue:7

    Topics: Age Factors; Animals; Anticonvulsants; Benzodiazepines; Clobazam; Dioxolanes; Disease Models, Animal

2012
Miconazole and clobazam; a useful interaction in Dravet's syndrome?
    Archives of disease in childhood, 2004, Volume: 89, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Child; Clobazam; Drug Interactions; Drug Therapy, Combination; Fem

2004
Hypersensitivity to topiramate sprinkle capsules does not preclude the use of topiramate tablets.
    Paediatric drugs, 2004, Volume: 6, Issue:2

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Benzodiazepines; Capsules; Carbamazepine; Clobaza

2004
Hemifacial seizures and cerebellar tumor: a rare co-existence.
    Indian pediatrics, 2007, Volume: 44, Issue:5

    Topics: Anticonvulsants; Benzodiazepines; Cerebellar Neoplasms; Child, Preschool; Clobazam; Comorbidity; Gan

2007
Plasma concentrations of clobazam and its N-desmethyl metabolite; protection against pentetrazol-induced convulsions in mice.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Injecti

1984
Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats.
    Epilepsia, 1982, Volume: 23, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepa

1982
Eating seizures.
    European neurology, 1983, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child;

1983
Clobazam-induced systemic lupus erythematosus.
    Clinical rheumatology, 1995, Volume: 14, Issue:1

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; Clobazam; Female; H

1995
Structure-activity relationships in thienodiazepine and benzodiazepine derivatives.
    Farmaco (Societa chimica italiana : 1989), 1994, Volume: 49, Issue:3

    Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Benzodiazepines; Benz

1994
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Cloba

1996
Antipentylenetetrazol action of clobazam in developing rats.
    Physiological research, 1999, Volume: 48, Issue:6

    Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Convul

1999
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections.
    Behavioural brain research, 1992, Nov-30, Volume: 52, Issue:1

    Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Arousal; Behavior, Animal; Benz

1992
Tolerance to the anticonvulsant effects of clobazam in mice.
    Neuropharmacology, 1992, Volume: 31, Issue:2

    Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepino

1992
Repeated anticonvulsant testing: contingent tolerance to diazepam and clobazam in kindled rats.
    Epilepsy research, 1992, Volume: 11, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepa

1992
[Maprotiline poisoning in an eleven-month-old infant].
    Pediatrie, 1990, Volume: 45, Issue:1

    Topics: Anthracenes; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Bundle-Branch Block; Clobazam;

1990
Phenytoin toxicity due to interaction with clobazam.
    Neurology, 1991, Volume: 41, Issue:2 ( Pt 1)

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Chromatography, Hig

1991
Metabolic profiling of valproic acid in patients using negative-ion chemical ionization gas chromatography-mass spectrometry.
    Journal of chromatography, 1990, May-18, Volume: 527, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Ch

1990
Etifoxine: evaluation of its anticonvulsant profile in mice in comparison with sodium valproate, phenytoin and clobazam.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Electro

1985
Potentiation of clobazam's anticonvulsant activity by etifoxine, a non-benzodiazepine tranquilizer, in mice. Comparison studies with sodium valproate.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Drug Sy

1986
Clobazam for refractory childhood seizure disorders--a valuable supplementary drug.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1988, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Child, Preschool;

1988
On the anticonvulsant and psychotropic properties of clobazam--a preliminary study.
    Epilepsia, 1986, Volume: 27 Suppl 1

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy; Female; Humans;

1986