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clobazam and Abdominal Epilepsy

clobazam has been researched along with Abdominal Epilepsy in 20 studies

Clobazam: A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
clobazam : 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.

Research Excerpts

ExcerptRelevanceReference
"To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy."9.08Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures."8.98Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures."8.90Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014)
"A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated within a paediatric epilepsy surgery program."5.42[Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis]. ( Blanco-Beregana, M; Budke, M; Fournier-Del Castillo, MC; Garcia-Fernandez, M; Garcia-Penas, JJ; Melero-Llorente, J; Perez-Jimenez, MÁ; Robles-Bermejo, F, 2015)
"To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy."5.08Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures."4.98Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures."4.90Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014)
"Clobazam (CLB) has an important antiepileptic effect and is less expensive than the new antiepileptic drugs (AEDs), but still has not been considered as first-line drug in the treatment of epilepsy."2.70Efficacy of clobazam as add-on therapy in patients with refractory partial epilepsy. ( Carvalho, MI; Cendes, F; Guerreiro, CA; Marques, LH; Montenegro, MA; Mory, SB; Noronha, AL, 2001)
"Gabapentin was started at 400 mg/day and was individually titrated to effective tolerable dose up to 2400 mg/day."2.69Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice. ( Bruni, J, 1998)
"The effect of 1,5-benzodiazepine clobazam was assessed in a double-blind add-on trial in 20 patients with chronic complex partial seizures uncontrolled by maximally tolerable daily dosage of standard antiepileptic drug therapy."2.66Clobazam for refractory focal epilepsy. A controlled trial. ( Roeder-Wanner, U; Rohde, M; Schmidt, D; Wolf, P, 1986)
"A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated within a paediatric epilepsy surgery program."1.42[Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis]. ( Blanco-Beregana, M; Budke, M; Fournier-Del Castillo, MC; Garcia-Fernandez, M; Garcia-Penas, JJ; Melero-Llorente, J; Perez-Jimenez, MÁ; Robles-Bermejo, F, 2015)
"Clobazam was introduced as add-on therapy in patients with previous failure of at least two monotherapies."1.33Effectiveness of clobazam as add-on therapy in children with refractory focal epilepsy. ( da Silveira, MR; Franzon, RC; Guerreiro, CA; Guerreiro, MM; Montenegro, MA, 2006)
"Three patients aged 16, 19, and 65 years with a 13- to 36-year history of partial epilepsy were receiving a therapeutic dosage of carbamazepine or phenobarbital plus either clobazam (CLB) or valproate (VPA)."1.30Negative myoclonic status due to antiepileptic drug tapering: report of three cases. ( Aguglia, U; Gambardella, A; Oliveri, RL; Quattrone, A; Russo, C; Zappia, M, 1997)
"Carbamazepine has no effect on the EEG, in epilepsies with atypical course (atypical benign partial epilepsy, Landau-Kleffner syndrome, epilepsy with continuous spikes and waves during slow sleep [CSWS]) carbamazepine usually has no effect either on the seizures or on the EEG, on the contrary, in some cases both may even get worse."1.29Treatment of "benign" partial epilepsies of childhood, including atypical forms. ( Gross-Selbeck, G, 1995)
"Clobazam was given in addition to conventional antiepileptic therapy, beginning with a dose of 20 mg at night."1.27Clobazam in the treatment of epilepsy. ( Bury, R; Fullinfaw, R; Kilpatrick, C; Moulds, R, 1987)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.00)18.7374
1990's6 (30.00)18.2507
2000's5 (25.00)29.6817
2010's5 (25.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Gimigliano, F1
Arya, R2
Giridharan, N1
Anand, V2
Garg, SK2
Imataka, G1
Noguchi, M1
Tsukada, K1
Takahashi, T1
Yamanouchi, H1
Arisaka, O1
Tanaka, S1
Tanaka, T1
Michael, BD1
Fournier-Del Castillo, MC1
Melero-Llorente, J1
Blanco-Beregana, M1
Robles-Bermejo, F1
Budke, M1
Garcia-Fernandez, M1
Garcia-Penas, JJ1
Perez-Jimenez, MÁ1
Héberlé, C1
Berquin, P1
Larnicol, N1
Wallois, F1
Iwasaki, T1
Miura, H1
Sunaoshi, W1
Hosoda, N1
Takei, K1
Katayama, F1
da Silveira, MR1
Montenegro, MA2
Franzon, RC1
Guerreiro, CA2
Guerreiro, MM1
Dulac, O1
Figueroa, D1
Rey, E1
Arthuis, M1
Gross-Selbeck, G1
Buchanan, N1
Gambardella, A1
Aguglia, U1
Oliveri, RL1
Russo, C1
Zappia, M1
Quattrone, A1
Bruni, J1
Contin, M1
Riva, R1
Albani, F1
Baruzzi, AA1
Cendes, F1
Noronha, AL1
Mory, SB1
Carvalho, MI1
Marques, LH1
Guilloton, L1
Burckard, E1
Fresse, S1
Drouet, A1
Felten, D1
Schmidt, D1
Rohde, M1
Wolf, P1
Roeder-Wanner, U1
Kilpatrick, C1
Bury, R1
Fullinfaw, R1
Moulds, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]Phase 22 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

InterventionAbscence seizures (Number)
Week 8 Baseline165
Week 12 Verapamil 4mg/kg/Day101

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionGeneral tonic-clonic seizures (Number)
Week 8 Baseline39
Week 12 Verapamil 4mg/kg/Day14

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionMyoclonic seizures (Number)
Week 8 Baseline116
Week 12 Verapamil 4mg/kg/Day175

Reviews

3 reviews available for clobazam and Abdominal Epilepsy

ArticleYear
Is clobazam monotherapy effective and safe in people with focal or generalized seizures? A Cochrane Review summary with commentary.
    Developmental medicine and child neurology, 2020, Volume: 62, Issue:6

    Topics: Anticonvulsants; Clobazam; Epilepsies, Partial; Epilepsy, Generalized; Humans

2020
Clobazam monotherapy for focal or generalized seizures.
    The Cochrane database of systematic reviews, 2018, 07-11, Volume: 7

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par

2018
Clobazam monotherapy for partial-onset or generalized-onset seizures.
    The Cochrane database of systematic reviews, 2014, Oct-04, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par

2014

Trials

5 trials available for clobazam and Abdominal Epilepsy

ArticleYear
Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1998, Volume: 25, Issue:2

    Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anti-Anxiety Agents; Anticonvulsants;

1998
Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy.
    Epilepsia, 1998, Volume: 39, Issue:9

    Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; C

1998
Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Chil

1999
Efficacy of clobazam as add-on therapy in patients with refractory partial epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Clobazam; Drug Admin

2001
Clobazam for refractory focal epilepsy. A controlled trial.
    Archives of neurology, 1986, Volume: 43, Issue:8

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic

1986

Other Studies

12 other studies available for clobazam and Abdominal Epilepsy

ArticleYear
Partial epilepsy and developmental delay in infant with ring chromosome 14.
    Genetic counseling (Geneva, Switzerland), 2013, Volume: 24, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Chromosome Disorders; Chromosomes, Human, Pair 1

2013
Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2013, Volume: 15, Issue:2

    Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Drug Therapy, Combination; Epilepsies, Partial; E

2013
[Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis].
    Revista de neurologia, 2015, Jan-16, Volume: 60, Issue:2

    Topics: Acetamides; Anticonvulsants; Benzodiazepines; Child; Clobazam; Cognition Disorders; Dibenzazepines;

2015
Vagus nerve stimulation in a case of epilepsy with CSWSS: respiratory side effects during sleep.
    Epilepsia, 2002, Volume: 43, Issue:10

    Topics: Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Clobazam; Combined Modali

2002
[A case of intractable epilepsy showing frequent gelastic seizures by administration of clobazam].
    No to hattatsu = Brain and development, 2003, Volume: 35, Issue:5

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Clobazam; Epilepsies, Partial; Humans; Laughter; Male;

2003
Effectiveness of clobazam as add-on therapy in children with refractory focal epilepsy.
    Arquivos de neuro-psiquiatria, 2006, Volume: 64, Issue:3B

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Electroencephalogra

2006
[Monotherapy with clobazam in epilepsies in children].
    Presse medicale (Paris, France : 1983), 1983, Apr-16, Volume: 12, Issue:17

    Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; Child,

1983
Treatment of "benign" partial epilepsies of childhood, including atypical forms.
    Neuropediatrics, 1995, Volume: 26, Issue:1

    Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinone

1995
Clobazam in the treatment of epilepsy: prospective follow-up to 8 years.
    Journal of the Royal Society of Medicine, 1993, Volume: 86, Issue:7

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child;

1993
Negative myoclonic status due to antiepileptic drug tapering: report of three cases.
    Epilepsia, 1997, Volume: 38, Issue:7

    Topics: Adolescent; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cerebral

1997
[Epileptic crisis after antimalaria chemoprophylaxis with chloroquine].
    Presse medicale (Paris, France : 1983), 2001, Nov-24, Volume: 30, Issue:35

    Topics: Anti-Anxiety Agents; Anticonvulsants; Antimalarials; Benzodiazepines; Chloroquine; Clobazam; Epileps

2001
Clobazam in the treatment of epilepsy.
    Clinical and experimental neurology, 1987, Volume: 23

    Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinone

1987