clivorine and Lung-Neoplasms

clivorine has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for clivorine and Lung-Neoplasms

Article	Year
CArcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata. Cancer letters, 1980, Volume: 10, Issue:2 The carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata, was studied in inbred ACI rats. Twelve animals in the experimental group received a 0.005% solution of clivorine in drinking water for 340 days and survived beyond 440 days after the beginning of the experiment. Of this group, 8 developed tumors in the liver; 2 developed hemangioendothelial sarcomas, and 6 developed neoplastic nodules. The hemangioendothelial sarcoma showed metastasis in the lung of one rat. No tumors were observed in the liver of the control animals. Topics: Animals; Carcinogens; Female; Hemangiosarcoma; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Pyrrolizidine Alkaloids; Rats	1980

Article

Year

CArcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata.

Cancer letters, 1980, Volume: 10, Issue:2

The carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata, was studied in inbred ACI rats. Twelve animals in the experimental group received a 0.005% solution of clivorine in drinking water for 340 days and survived beyond 440 days after the beginning of the experiment. Of this group, 8 developed tumors in the liver; 2 developed hemangioendothelial sarcomas, and 6 developed neoplastic nodules. The hemangioendothelial sarcoma showed metastasis in the lung of one rat. No tumors were observed in the liver of the control animals.

Topics: Animals; Carcinogens; Female; Hemangiosarcoma; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Pyrrolizidine Alkaloids; Rats

1980