clioquinol has been researched along with Tauopathies in 1 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Tauopathies: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tauopathies are characterized by the pathological accumulation of the microtubule associated protein tau within the brain." | 1.48 | Targeting metals rescues the phenotype in an animal model of tauopathy. ( Adlard, PA; Barnham, KJ; Bray, L; Bush, AI; Chan, J; Cherny, RA; Finkelstein, DI; Gunawan, L; Hung, LW; Liu, XM; Okamura, N; Parsons, J; Sedjahtera, A; Villemagne, VL; Yanai, K, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sedjahtera, A | 1 |
| Gunawan, L | 1 |
| Bray, L | 1 |
| Hung, LW | 1 |
| Parsons, J | 1 |
| Okamura, N | 1 |
| Villemagne, VL | 1 |
| Yanai, K | 1 |
| Liu, XM | 1 |
| Chan, J | 1 |
| Bush, AI | 1 |
| Finkelstein, DI | 1 |
| Barnham, KJ | 1 |
| Cherny, RA | 1 |
| Adlard, PA | 1 |
1 other study available for clioquinol and Tauopathies
| Article | Year |
|---|---|
Targeting metals rescues the phenotype in an animal model of tauopathy.
Topics: Animals; Clioquinol; Female; Male; Memory; Mice; Spatial Learning; Tauopathies | 2018 |