clioquinol has been researched along with Syndrome in 63 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol." | 7.66 | Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan. ( Hanakago, R; Uono, M, 1981) |
| " One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol." | 3.66 | Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan. ( Hanakago, R; Uono, M, 1981) |
| "A man, aged 46, who had been taking Clioquinol in high doses for a long period, developed a characteristic neurological syndrome of subacute myelo-optic neuropathy rather abruptly." | 3.65 | Ultrastructural study of a muscle biopsy from a patient with subacute myelo-optic neuropathy. ( de Coster, W; de Reuck, J; Otte, G; Thiery, E; vander Eecken, H, 1977) |
| "Those patients with complete or near complete blindness were profoundly handicapped so that the ratio of patients with a life-long institutionalization was high compared to the groups with less severe visual disturbance." | 1.31 | [Analysis of SMON at 30 years after its outbreak ending: special reference to those patients with blindness]. ( Iwashita, H; Konagaya, M; Matsuoka, Y; Nakae, K, 2002) |
| "Subacute myelopathy was seen in six patients, optico-myelopathy in two, and myeloneuropathy only once." | 1.27 | SMON as seen from Bombay. ( Wadia, NH, 1984) |
| " Pharmacokinetic studies in the dog demonstrated that the compound was well absorbed; the bioavailability was 36% of the dose of 1 mg/kg." | 1.27 | Metabolism of 14C-iodochlorhydroxyquin in the dog and the rat. ( Inaba, T; Jurima, M; Kalow, W, 1984) |
| "Clioquinol can increase the penetration of metallic cations through cellular membranes by forming lipophilic metal-chelates." | 1.27 | The aetiology of SMON may involve an interaction between clioquinol and environmental metals. ( Tjälve, H, 1984) |
| "A case of acrodermatitis enteropathica occurred with corneal changes consisting of linear subepithelial corneal opacities." | 1.25 | Acrodermatitis enteropathica. Corneal involvement with histochemical and electron micrographic studies. ( Doughman, DJ; Harris, JE; Hill, CW; Warshawsky, RS, 1975) |
| "8 g/kg) in shorter periods (19-47 days) and there was no difference between each group on the increasing dosage and on fixed dosage." | 1.25 | Neurotoxity of iodoxyquinoline: a further study on beagle dogs. ( Ikeda, H; Kuroda, S; Otsuki, S; Tateishi, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (85.71) | 18.7374 |
| 1990's | 4 (6.35) | 18.2507 |
| 2000's | 4 (6.35) | 29.6817 |
| 2010's | 1 (1.59) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perez, DR | 1 |
| Sklar, LA | 1 |
| Chigaev, A | 1 |
| Konagaya, M | 1 |
| Matsuoka, Y | 1 |
| Nakae, K | 2 |
| Iwashita, H | 2 |
| Igata, A | 2 |
| Yamanaka, Y | 1 |
| Asahina, M | 1 |
| Akaogi, Y | 1 |
| Koyama, Y | 1 |
| Hattori, T | 1 |
| Thomas, PK | 3 |
| Wadia, NH | 4 |
| Gilland, O | 1 |
| Hansson, O | 2 |
| Herxheimer, A | 1 |
| Soffer, M | 1 |
| Basdevant, A | 1 |
| Sarragoussi, JJ | 1 |
| Raison, J | 1 |
| Guy-Grand, B | 1 |
| Massons Cirera, J | 1 |
| Zunzunegui Costas, J | 1 |
| Titus Alvareda, F | 1 |
| Schaumburg, HH | 1 |
| Spencer, PS | 1 |
| Kaeser, HE | 1 |
| Pallis, CA | 1 |
| Rose, FC | 2 |
| Jurima, M | 1 |
| Kalow, W | 1 |
| Inaba, T | 1 |
| Pallis, C | 1 |
| Tjälve, H | 1 |
| Okada, H | 1 |
| Aoki, K | 2 |
| Ohno, Y | 1 |
| Kitazawa, S | 1 |
| Ohtani, M | 2 |
| Sturtevant, FM | 1 |
| Hanakago, R | 1 |
| Uono, M | 1 |
| Matsuki, Y | 1 |
| Yoshimura, S | 1 |
| Abe, M | 1 |
| Arbiser, JL | 1 |
| Kraeft, SK | 1 |
| van Leeuwen, R | 1 |
| Hurwitz, SJ | 1 |
| Selig, M | 1 |
| Dickersin, GR | 1 |
| Flint, A | 1 |
| Byers, HR | 1 |
| Chen, LB | 1 |
| Tabira, T | 1 |
| Bernard, G | 1 |
| Griffith, RW | 1 |
| Otte, G | 2 |
| de Coster, W | 2 |
| Thiery, E | 2 |
| de Reuck, J | 2 |
| vander Eecken, H | 2 |
| Worden, AN | 1 |
| Heywood, R | 1 |
| Lee, JA | 1 |
| Shigematsu, I | 3 |
| Yanagawa, H | 2 |
| Asao, M | 1 |
| Fabiani, F | 1 |
| Sinibaldi, L | 1 |
| Warshawsky, RS | 1 |
| Hill, CW | 1 |
| Doughman, DJ | 1 |
| Harris, JE | 1 |
| Tateishi, J | 3 |
| Kono, R | 1 |
| Shiraki, H | 1 |
| Kuroda, S | 2 |
| Ikeda, H | 2 |
| Otsuki, S | 1 |
| Sobue, I | 1 |
| Yamamoto, S | 1 |
| Kusui, K | 1 |
| Tamura, Z | 2 |
| Toyokura, Y | 2 |
| Takasu, T | 2 |
| Matsuoka, O | 1 |
| Török, E | 1 |
| Földes, G | 1 |
| Frank, K | 1 |
| Kereszty, M | 1 |
| Kiss, P | 1 |
| Molnár, A | 1 |
| Révesz, T | 1 |
| Rosner, E | 1 |
| Szigeti, R | 1 |
| Török, I | 1 |
| Hayakawa, K | 1 |
| Imanari, T | 1 |
| Buchanan, DS | 1 |
| Mathew, R | 1 |
| Gupta, PS | 1 |
| Kasamaki, A | 1 |
| Furuya, K | 1 |
| Kanamitsu, M | 1 |
| Sonoda, K | 1 |
| Vanĕcek, J | 1 |
| Fink, Z | 1 |
| Matsuda, M | 1 |
| Yanagisawa, N | 1 |
| Tsukada, N | 1 |
| Katahira, K | 1 |
| Kobayshi, T | 1 |
| Higashida, T | 1 |
| Kamae, S | 1 |
| Nakajima, Y | 1 |
| Fujimoto, S | 1 |
| Bhasin, DK | 1 |
| Raina, R | 1 |
| Mehta, SK | 1 |
| Arora, MM | 1 |
| Wolffers, I | 1 |
| Oakley, GP | 1 |
| Ferrier, TM | 1 |
| Eadie, MJ | 1 |
| Dahl, KB | 1 |
| Vitale, C | 1 |
| Feldman, JL | 1 |
| Hubault, A | 1 |
| Weisbecker, J | 1 |
| Bechetoille, A | 1 |
| de Sèze, S | 1 |
6 reviews available for clioquinol and Syndrome
| Article | Year |
|---|---|
Clioquinol: To harm or heal.
Topics: Animals; Anti-Infective Agents; Asian People; ATP-Binding Cassette Transporters; Clioquinol; Cyclic | 2019 |
Selective vulnerability of the centrifugal and centripetal axons of primary sensory neurons.
Topics: Acrylamides; Animals; Axons; Clioquinol; Dogs; Ganglia, Spinal; Haplorhini; Humans; Nerve Degenerati | 1982 |
[SMON and pharmacokinetics of chinoform with special reference to animal species difference].
Topics: Amebicides; Animals; Cats; Clioquinol; Dogs; Dose-Response Relationship, Drug; Humans; Lipid Peroxid | 1997 |
[Neurotoxicity of chinoform].
Topics: Acute Disease; Amebicides; Clioquinol; Humans; Myelitis; Optic Neuritis; Quality of Life; Severity o | 1999 |
[Neurotoxicity of chinoform].
Topics: Animals; Cats; Child; Clioquinol; Dogs; Guinea Pigs; Haplorhini; Humans; Lethal Dose 50; Mice; Myeli | 1976 |
Introductory review of subacute myeolo-optico-neuropathy (SMON) and its studies done by the SMON Research Commission.
Topics: Clioquinol; Humans; Japan; Male; Middle Aged; Myelitis; Optic Neuritis; Syndrome | 1975 |
57 other studies available for clioquinol and Syndrome
| Article | Year |
|---|---|
[Analysis of SMON at 30 years after its outbreak ending: special reference to those patients with blindness].
Topics: Adult; Aged; Blindness; Clioquinol; Disease Outbreaks; Female; Follow-Up Studies; Humans; Japan; Mal | 2002 |
[Contribution of Japanese researchers to progress in the field of neurology in the last 100 years: SMON].
Topics: Clioquinol; History, 20th Century; Humans; Myelitis; Optic Neuritis; Syndrome | 2002 |
Diminished skin vasodilator response to local heating in patients with long-standingsubacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Autonomic Dysreflexia; Autonomic Nervous System Dise | 2007 |
Neurotoxicity of halogenated hydroxyquinolines: non-Japanese cases.
Topics: Clioquinol; Humans; Hydroxyquinolines; Japan; Optic Atrophy; Peripheral Nervous System Diseases; Spi | 1984 |
SMON as seen from Bombay.
Topics: Adult; Aged; Child; Clioquinol; Female; Humans; Hydroxyquinolines; India; Japan; Male; Middle Aged; | 1984 |
A neurological evaluation of purported cases of SMON in Sweden.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clioquinol; Female; Humans; Hydroxyquinolines; Mal | 1984 |
Idiosyncratic neurotoxicity: clioquinol and bismuth.
Topics: Austria; Bismuth; Brain Diseases; Clioquinol; Dose-Response Relationship, Drug; France; Humans; Japa | 1980 |
Neurotoxicity of oxyquinolines.
Topics: Abdomen; Clioquinol; Humans; Myelitis; Optic Neuritis; Pain; Syndrome | 1980 |
Oxyquinoline toxicity.
Topics: Clioquinol; Diverticulum; Drug Combinations; France; Humans; Hydroxyquinolines; Male; Middle Aged; M | 1983 |
[A case of myelo-optic neuropathy preceded by abdominal symptoms].
Topics: Abdomen; Clioquinol; Humans; Hydroxyquinolines; Male; Middle Aged; Optic Atrophy; Pain; Spinal Cord | 1983 |
Central distal axonopathy syndromes: newly recognized models of naturally occurring human degenerative disease.
Topics: Animals; Axons; Central Nervous System Diseases; Clioquinol; Disease Models, Animal; Dogs; Humans; L | 1984 |
Metabolism of 14C-iodochlorhydroxyquin in the dog and the rat.
Topics: Administration, Oral; Animals; Bile; Biological Availability; Clioquinol; Dogs; Female; Hydroxyquino | 1984 |
Some thoughts on 'SMON'.
Topics: Clioquinol; Diagnosis, Differential; Humans; Hydroxyquinolines; Japan; Optic Atrophy; Spinal Cord Di | 1984 |
The aetiology of SMON may involve an interaction between clioquinol and environmental metals.
Topics: Clioquinol; Drug Interactions; Environmental Pollutants; Humans; Hydroxyquinolines; Japan; Metals; M | 1984 |
Effects of metal-containing drugs taken simultaneously with clioquinol upon clinical features of SMON.
Topics: Clioquinol; Drug Interactions; Female; Humans; Hydroxyquinolines; Male; Metals; Middle Aged; Motor A | 1984 |
Zinc deficiency, acrodermatitis enteropathica, optic atrophy, subacute myelo-optic neuropathy, and 5,7-dihalo-8-quinolinols.
Topics: Acrodermatitis; Clioquinol; Humans; Hydroxyquinolines; Myelitis; Optic Atrophy; Optic Neuritis; Oxyq | 1980 |
Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan.
Topics: Acrodermatitis; Adult; Clioquinol; Global Health; Humans; Japan; Male; Myelitis; Optic Neuritis; Syn | 1981 |
Clioquinol-zinc chelate: a candidate causative agent of subacute myelo-optic neuropathy.
Topics: Chelating Agents; Clioquinol; Humans; Membrane Potentials; Mitochondria; Myelitis; Optic Neuritis; S | 1998 |
Clioquinol's return: cautions from Japan.
Topics: Alzheimer Disease; Animals; Clinical Trials, Phase II as Topic; Clioquinol; Humans; Japan; Mice; Mye | 2001 |
Clioquinol.
Topics: Benzoates; Clioquinol; Drug Combinations; Drug Industry; Myelitis; Optic Neuritis; Oxyquinoline; Qui | 1977 |
Ultrastructural study of a muscle biopsy from a patient with subacute myelo-optic neuropathy.
Topics: Clioquinol; Humans; Inclusion Bodies; Male; Middle Aged; Muscles; Myelin Sheath; Myelitis; Neuromusc | 1977 |
Toxicity of oxyquinolines.
Topics: Clioquinol; Humans; Hydroxyquinolines; Myelitis; Optic Neuritis; Oxyquinoline; Syndrome | 1977 |
Clioquinol toxicity.
Topics: Animals; Clioquinol; Dogs; Myelitis; Optic Neuritis; Syndrome | 1978 |
Data on clioquinol and S.M.O.N.
Topics: Clioquinol; Humans; Japan; Myelitis; Optic Neuritis; Syndrome | 1978 |
Data on clioquinol and S.M.O.N.
Topics: Clioquinol; Humans; Japan; Myelitis; Optic Neuritis; Syndrome | 1978 |
Clioquinol and S.M.O.N.: Reanalysis of original data.
Topics: Clioquinol; Drug Evaluation; Humans; Japan; Myelitis; Optic Neuritis; Population Surveillance; Syndr | 1979 |
S.M.O.N. in Italy.
Topics: Adult; Clioquinol; Diagnosis, Differential; Female; Humans; Italy; Myelitis; Optic Neuritis; Syndrom | 1977 |
Acrodermatitis enteropathica. Corneal involvement with histochemical and electron micrographic studies.
Topics: Acrodermatitis; Biopsy; Child; Child, Preschool; Clioquinol; Corneal Opacity; Histocytochemistry; Hu | 1975 |
The neuropathology of subacute myelo-optico-neuropathy, "SMON", in the humans: --with special reference to the quinoform intoxication.
Topics: Adolescent; Adult; Aged; Brain; Brain Stem; Cerebellum; Child; Clioquinol; Cranial Nerves; Diencepha | 1975 |
Neurotoxity of iodoxyquinoline: a further study on beagle dogs.
Topics: Administration, Oral; Animals; Clioquinol; Disease Models, Animal; Dogs; Intestines; Kidney; Liver; | 1975 |
Prognosis of SMON patients.
Topics: Adult; Age Factors; Aged; Clioquinol; Female; Humans; Male; Middle Aged; Myelitis; Optic Neuritis; P | 1975 |
Epidemiological approach to SMON (subacute myelo-optico-neuropathy).
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Clioquinol; Female; Follow-Up Studies | 1975 |
Subacute myelo-optico-neuropathy (SMON) and clioquinol: -A response to doubts about clioquinol causation theory-.
Topics: Clioquinol; Dose-Response Relationship, Drug; Epidemiologic Methods; Humans; Japan; Myelitis; Optic | 1975 |
Outline of the joint SMON investigation by the clinical section.
Topics: Clioquinol; Follow-Up Studies; Humans; Japan; Myelitis; Optic Neuritis; Syndrome | 1975 |
Clinical chemistry of clioquinol.
Topics: Adult; Aged; Animals; Chemical Phenomena; Chemistry; Clioquinol; Female; Humans; Male; Mice; Middle | 1975 |
Experimental studies utilizing radionuclide-labelled clioquinol as tracer in vivo.
Topics: Animals; Autoradiography; Biotransformation; Clioquinol; Digestive System; Humans; Liver; Myelitis; | 1975 |
Clinical features of SMON.
Topics: Adult; Clioquinol; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Myelitis; Optic Neuri | 1975 |
Subacute myelo-optic neuropathy. A toxic or a viral etiology?
Topics: Clioquinol; Humans; Male; Middle Aged; Myelitis; Optic Neuritis; Syndrome | 1976 |
[Enteropathic acrodermatitis].
Topics: Acrodermatitis; Administration, Oral; Adolescent; Child; Clioquinol; Drug Therapy, Combination; Fema | 1977 |
Some observations on SMON from Bombay.
Topics: Adult; Aged; Child; Clioquinol; Female; Humans; India; Male; Middle Aged; Myelitis; Optic Neuritis; | 1977 |
Relationship between neurological symptoms and concentrations of clioquinol in serum and nervous systems of beagle dogs.
Topics: Animals; Central Nervous System; Clioquinol; Dogs; Female; Myelitis; Optic Neuritis; Syndrome | 1977 |
[SMON syndrome].
Topics: Clioquinol; Humans; Myelitis; Optic Neuritis; Syndrome | 1977 |
Iatrogenic causes of neurologic disorders: part 1. Affect, convulsions, and encephalopathies.
Topics: Affective Symptoms; Aged; Antiparkinson Agents; Brain Diseases; Clioquinol; Cognition Disorders; Hum | 1978 |
Sub-acute myelo-optico neuropathy (a case report).
Topics: Adult; Clioquinol; Diagnosis, Differential; Female; Humans; Myelitis; Optic Neuritis; Syndrome | 1978 |
Demonstration of antibody activity to clioquinol in sera of experimental rabbits and patients with subacute myelo-optico-neuropathy.
Topics: Adult; Aged; Animals; Antibodies; Antibody Specificity; Clioquinol; Hemagglutination Inhibition Test | 1978 |
SMON and other socially induced diseases in Japan.
Topics: Clioquinol; Humans; Japan; Life Style; Myelitis; Optic Neuritis; Social Isolation; Social Security; | 1978 |
[Subacute myelo-optic neuritis].
Topics: Clioquinol; Humans; Myelitis; Optic Neuritis; Syndrome | 1979 |
[Subsets of peripheral blood lymphocytes and ageing in patients with SMON].
Topics: Aged; Aging; Clioquinol; Humans; Leukocyte Count; Lymphocyte Subsets; Middle Aged; Myelitis; Nervous | 1991 |
Ethnic differences in drugs and xenobiotics. Clioquinol.
Topics: Adult; Child, Preschool; Clioquinol; Female; Humans; Hydroxyquinolines; Japan; Male; Middle Aged; My | 1986 |
Chinese acupuncture treatment for SMON patients.
Topics: Acupuncture Therapy; Adolescent; Adult; Aged; Clioquinol; Female; Humans; Hydroxyquinolines; Male; M | 1986 |
Assessment of neurotoxicity of clioquinol (Enterovioform) by visual evoked potentials. A preliminary communication.
Topics: Adult; Clioquinol; Diarrhea; Evoked Potentials, Visual; Female; Humans; Hydroxyquinolines; Male; Mid | 1985 |
[The history of quinolines].
Topics: Clioquinol; History, 20th Century; Humans; Hydroxyquinolines; Japan; Myelitis; Optic Neuritis; Quino | 1985 |
The neurotoxicity of the halogenated hydroxyquinolines. A commentary.
Topics: Abdomen; Anti-Infective Agents; Central Nervous System; Chlorquinaldol; Clioquinol; Disease Outbreak | 1973 |
Clioquinol encephalopathy.
Topics: Adult; Brain Diseases; Clioquinol; Cognition Disorders; Female; Headache; Humans; Male; Memory Disor | 1973 |
Is there SMON in India?
Topics: Abdomen; Adult; Clioquinol; Female; Humans; India; Male; Middle Aged; Myelitis; Optic Neuritis; Pain | 1973 |
[Acrodermatitis enteropathica treated with iodochloroxyquinolin].
Topics: Acrodermatitis; Adult; Clioquinol; Humans; Malabsorption Syndromes; Male; Nails, Malformed; Syndrome | 1974 |
[Subacute neuromyelitis with optic neuritis following chloroiodoquine. A new case].
Topics: Clioquinol; Colitis; Constipation; Female; Humans; Middle Aged; Multiple Sclerosis; Neuromyelitis Op | 1974 |