clioquinol has been researched along with Protein Aggregation, Pathological in 4 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To target the multi-facets of Alzheimer's disease (AD), a series of novel GSK-3β inhibitors containing the 2,3-diaminopyridine moiety were designed and synthesized." | 1.51 | Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease. ( Liu, P; Liu, ZP; Shi, XL; Wu, JD, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, XL | 1 |
| Wu, JD | 1 |
| Liu, P | 1 |
| Liu, ZP | 1 |
| Sharma, AK | 1 |
| Kim, J | 2 |
| Prior, JT | 1 |
| Hawco, NJ | 1 |
| Rath, NP | 1 |
| Mirica, LM | 1 |
| Finkelstein, DI | 1 |
| Hare, DJ | 1 |
| Billings, JL | 1 |
| Sedjahtera, A | 1 |
| Nurjono, M | 1 |
| Arthofer, E | 1 |
| George, S | 1 |
| Culvenor, JG | 1 |
| Bush, AI | 1 |
| Adlard, PA | 1 |
| Fu, CL | 1 |
| Hsu, LS | 1 |
| Liao, YF | 1 |
| Hu, MK | 1 |
4 other studies available for clioquinol and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease.
Topics: Alzheimer Disease; Amides; Amines; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Chelating | 2019 |
Small bifunctional chelators that do not disaggregate amyloid β fibrils exhibit reduced cellular toxicity.
Topics: Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Chelating Agents; Clioquinol; Cryst | 2014 |
Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice.
Topics: alpha-Synuclein; Animals; Brain; Clioquinol; Cognition Disorders; Disease Models, Animal; Explorator | 2016 |
New Hydroxyquinoline-Based Derivatives as Potent Modulators of Amyloid-β Aggregations.
Topics: Amyloid beta-Peptides; Chelating Agents; Clioquinol; Copper; Hydroxyquinolines; Protein Aggregation, | 2016 |