clioquinol and Precancerous Conditions
clioquinol has been researched along with Precancerous Conditions in 2 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" In the current study, we investigate whether clioquinol (CQ), an analog of 8-hydroxyquinoline and an Alzheimer's disease drug, and pyrrolidine dithiocarbamate (PDTC), a known copper-binding compound and antioxidant, can interact with copper to form cancer-specific proteasome inhibitors and apoptosis inducers in human breast cancer cells." | 7.73 | Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells. ( Chen, D; Cui, QC; Daniel, KG; Dou, QP; Miller, FR; Orlu, S, 2005) |
" In the current study, we investigate whether clioquinol (CQ), an analog of 8-hydroxyquinoline and an Alzheimer's disease drug, and pyrrolidine dithiocarbamate (PDTC), a known copper-binding compound and antioxidant, can interact with copper to form cancer-specific proteasome inhibitors and apoptosis inducers in human breast cancer cells." | 3.73 | Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells. ( Chen, D; Cui, QC; Daniel, KG; Dou, QP; Miller, FR; Orlu, S, 2005) |
Research
Studies (2)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (50.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (50.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Daniel, KG | 1 |
Chen, D | 1 |
Orlu, S | 1 |
Cui, QC | 1 |
Miller, FR | 1 |
Dou, QP | 1 |
Katz, H | 1 |
Redding, KG | 1 |
Other Studies
2 other studies available for clioquinol and Precancerous Conditions
Article | Year |
---|---|
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.
Topics: Anti-Infective Agents, Local; Antioxidants; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Prol | 2005 |
Therapeutic challenge of premalignant and malignant skin lesions.
Topics: Acetates; Adrenal Cortex Hormones; Adult; Aged; Balanitis; Bowen's Disease; Clioquinol; Cryosurgery; | 1975 |