clioquinol has been researched along with Peripheral Nervous System Diseases in 24 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clioquinol is used for treatment of amoebiasis and infection with Dientamoeba fragilis." | 5.46 | [Clioquinol use for Dientamoeba fragilis infections is questionable]. ( Stricker, BHC; van Hunsel, F; van Nieuwkoop, C, 2017) |
| " Although clioquinol may show activity against Alzheimer's disease or malignancy, its toxic effects cause severe irreversible neurological sequelae." | 2.52 | [SMON: toxicity of clioquinol and the status quo]. ( Konagaya, M, 2015) |
| "Clioquinol or chinoform was strongly suspected as the cause of the disease because the iron chelate of chinoform was identified in the green urine of the patients." | 2.36 | Subacute myelo-optico-neuropathy (SMON) in Japan. With special reference to the autopsy cases. ( Egashira, Y; Matsuyama, H, 1982) |
| "The prevalence of subjective insomnia (6 ≤ Athens Insomnia Scale score) was 89." | 1.51 | Sleep problems in subacute myelo-optico neuropathy (SMON). ( Abe, K; Hishikawa, N; Ohta, Y; Sakai, K; Sato, K; Takemoto, M; Yamashita, T, 2019) |
| "Clioquinol is used for treatment of amoebiasis and infection with Dientamoeba fragilis." | 1.46 | [Clioquinol use for Dientamoeba fragilis infections is questionable]. ( Stricker, BHC; van Hunsel, F; van Nieuwkoop, C, 2017) |
| "Subacute myelopathy was seen in six patients, optico-myelopathy in two, and myeloneuropathy only once." | 1.27 | SMON as seen from Bombay. ( Wadia, NH, 1984) |
| " The onset of all manifestations (except toxic encephalopathy) was usually subacute, with subsequent partial recovery." | 1.26 | Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan. ( Baumgartner, G; Gawel, MJ; Kaeser, HE; Pallis, CA; Rose, FC; Schaumburg, HH; Thomas, PK; Wadia, NH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (62.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, H | 1 |
| Sasai, H | 1 |
| Kawamoto, N | 1 |
| Katsuyama, M | 1 |
| Minamiyama, M | 1 |
| Kuru, S | 1 |
| Fukao, T | 1 |
| Ohnishi, H | 1 |
| Konishi, T | 3 |
| Hayashi, K | 1 |
| Sugiyama, H | 1 |
| van Hunsel, F | 1 |
| van Nieuwkoop, C | 1 |
| Stricker, BHC | 1 |
| Hishikawa, N | 1 |
| Takemoto, M | 1 |
| Sato, K | 1 |
| Yamashita, T | 1 |
| Ohta, Y | 1 |
| Sakai, K | 2 |
| Abe, K | 1 |
| Konagaya, M | 3 |
| Saito, Y | 1 |
| Kimura, E | 1 |
| Hirano, T | 1 |
| Yamashita, S | 1 |
| Hirai, T | 1 |
| Uchida, Y | 1 |
| Maeda, Y | 1 |
| Uchino, M | 1 |
| Matsumoto, A | 1 |
| Takase, S | 1 |
| Mizutani, T | 1 |
| Sobue, G | 1 |
| Hayabara, T | 1 |
| Iwashita, H | 1 |
| Ujihira, T | 1 |
| Miyata, K | 1 |
| Matsuoka, Y | 1 |
| Thomas, PK | 2 |
| Wadia, NH | 2 |
| Gilland, O | 1 |
| Egashira, Y | 1 |
| Matsuyama, H | 1 |
| Mukoyama, M | 1 |
| Iida, M | 1 |
| Sobue, I | 1 |
| Le Quesne, PM | 1 |
| Thomann, P | 2 |
| Krinke, G | 2 |
| Hess, R | 2 |
| Schaumburg, HH | 2 |
| Spencer, PS | 1 |
| Baumgartner, G | 1 |
| Gawel, MJ | 1 |
| Kaeser, HE | 1 |
| Pallis, CA | 1 |
| Rose, FC | 1 |
| Shimada, Y | 1 |
| Tsuji, T | 1 |
| Igata, A | 1 |
| Steinitz, H | 1 |
| Terry, SI | 1 |
| McEwen, LM | 1 |
| Jones, EL | 1 |
| Searle, CE | 1 |
| Smith, WT | 1 |
| Cohen, D | 1 |
| Streifler, M | 1 |
4 reviews available for clioquinol and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
[SMON: toxicity of clioquinol and the status quo].
Topics: Clioquinol; Cognition; Demyelinating Diseases; Humans; Japan; Peripheral Nervous System Diseases; Sp | 2015 |
Subacute myelo-optico-neuropathy (SMON) in Japan. With special reference to the autopsy cases.
Topics: Adult; Aged; Animals; Autopsy; Clioquinol; Digestive System; Dogs; Female; Humans; Male; Middle Aged | 1982 |
Neurotoxic substances.
Topics: Acrylamides; Animals; Cats; Central Nervous System Diseases; Clioquinol; Environmental Exposure; Hex | 1975 |
[Toxicity studies on clioquinol in laboratory animals].
Topics: Animals; Clioquinol; Dogs; Nervous System Diseases; Peripheral Nerves; Peripheral Nervous System Dis | 1977 |
20 other studies available for clioquinol and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON).
Topics: ATP-Binding Cassette Transporters; Clioquinol; Humans; Japan; Multidrug Resistance-Associated Protei | 2022 |
The Aggravation of Depression with Aging in Japanese Patients with Subacute Myelo-optico-neuropathy (SMON).
Topics: Aged; Aged, 80 and over; Aging; Asian People; Clioquinol; Depressive Disorder; Female; Humans; Male; | 2017 |
[Clioquinol use for Dientamoeba fragilis infections is questionable].
Topics: Antiprotozoal Agents; Clioquinol; Dientamoebiasis; Humans; Netherlands; Peripheral Nervous System Di | 2017 |
Physical Disabilities Related to the Depressive Mental States of Japanese Patients with Subacute Myelo-optico-neuropathy.
Topics: Age Factors; Aged; Aged, 80 and over; Clioquinol; Depressive Disorder; Disability Evaluation; Female | 2018 |
Sleep problems in subacute myelo-optico neuropathy (SMON).
Topics: Aged; Aged, 80 and over; Clioquinol; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Per | 2019 |
The prevalence of dementia in subacute myelo-optico-neuropathy (SMON) patients who underwent medical checkups.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Infective Agents; Clioquinol; Dementia; Female; Hum | 2016 |
Cervical MRI of subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anthelmintics; Chelating Agents; Clioquinol; Copper; Female; Humans; Magnet | 2011 |
Clinical analysis of longstanding subacute myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban.
Topics: Aged; Aged, 80 and over; Amebicides; Autonomic Nervous System Diseases; Blindness; Clioquinol; Cohor | 2004 |
Neurotoxicity of halogenated hydroxyquinolines: non-Japanese cases.
Topics: Clioquinol; Humans; Hydroxyquinolines; Japan; Optic Atrophy; Peripheral Nervous System Diseases; Spi | 1984 |
SMON as seen from Bombay.
Topics: Adult; Aged; Child; Clioquinol; Female; Humans; Hydroxyquinolines; India; Japan; Male; Middle Aged; | 1984 |
A neurological evaluation of purported cases of SMON in Sweden.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clioquinol; Female; Humans; Hydroxyquinolines; Mal | 1984 |
Hyperbaric oxygen therapy for peripheral nerve damage induced in rabbits with clioquinol.
Topics: Animals; Atmosphere Exposure Chambers; Clioquinol; Hindlimb; Hyperbaric Oxygenation; Nerve Regenerat | 1975 |
Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog.
Topics: Animals; Axons; Brain; Brain Diseases; Clioquinol; Dogs; Ketones; Methyl n-Butyl Ketone; Microscopy, | 1979 |
Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Child, Preschool; Clioquinol; Dose-Response Relation | 1979 |
Halogenated oxyquinoline derivatives and neurological syndromes.
Topics: Abdomen; Administration, Oral; Adult; Aged; Clioquinol; Feces; Female; Fluorescent Antibody Techniqu | 1971 |
Entero-Vioform and organic neurologic disease.
Topics: Arthritis, Rheumatoid; Chloroquine; Clioquinol; Diarrhea; Humans; Malaria; Optic Atrophy; Peripheral | 1971 |
Transient dysaesthesiae and persistent leucocytosis after clioquinol therapy.
Topics: Adult; Anti-Infective Agents, Local; Arm; Ascaris; Blood Cell Count; Clioquinol; Diarrhea; Face; Fec | 1971 |
Neuropathy after clioquinol.
Topics: Anti-Infective Agents, Local; Clioquinol; Female; Humans; Male; Optic Neuritis; Paralysis; Periphera | 1971 |
Peripheral neuropathy in ageing rats fed clioquinol and a maize diet.
Topics: Age Factors; Animals; Clioquinol; Demyelinating Diseases; Diet; Male; Peripheral Nervous System Dise | 1973 |
[Hydroxyquinoline derivatives and the nervous system].
Topics: Acrodermatitis; Amebiasis; Child; Chloroquine; Clioquinol; Humans; Male; Paresthesia; Peripheral Ner | 1972 |