clioquinol has been researched along with Optic Neuritis in 101 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Optic Neuritis: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
| Excerpt | Relevance | Reference |
|---|---|---|
| " One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol." | 7.66 | Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan. ( Hanakago, R; Uono, M, 1981) |
| " One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol." | 3.66 | Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan. ( Hanakago, R; Uono, M, 1981) |
| "A man, aged 46, who had been taking Clioquinol in high doses for a long period, developed a characteristic neurological syndrome of subacute myelo-optic neuropathy rather abruptly." | 3.65 | Ultrastructural study of a muscle biopsy from a patient with subacute myelo-optic neuropathy. ( de Coster, W; de Reuck, J; Otte, G; Thiery, E; vander Eecken, H, 1977) |
| " An annotation on the 6th Revision of the Japan Pharmacopoeia (1954) allowed irregular increase in its dosage depending on the severity of illness." | 2.42 | [SMON--a model of the iatrogenic disease]. ( Takasu, T, 2003) |
| "Clioquinol or chinoform was strongly suspected as the cause of the disease because the iron chelate of chinoform was identified in the green urine of the patients." | 2.36 | Subacute myelo-optico-neuropathy (SMON) in Japan. With special reference to the autopsy cases. ( Egashira, Y; Matsuyama, H, 1982) |
| " Fourthly, there was no dose-response relationship." | 2.35 | Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis. ( Meade, TW, 1975) |
| "Clioquinol was used extensively in the mid-1900s as an amebicide to treat indigestion and diarrhea." | 1.40 | Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. ( Ibi, M; Iwata, K; Katsuyama, M; Matsumoto, M; Ohshima, Y; Yabe-Nishimura, C, 2014) |
| "Those patients with complete or near complete blindness were profoundly handicapped so that the ratio of patients with a life-long institutionalization was high compared to the groups with less severe visual disturbance." | 1.31 | [Analysis of SMON at 30 years after its outbreak ending: special reference to those patients with blindness]. ( Iwashita, H; Konagaya, M; Matsuoka, Y; Nakae, K, 2002) |
| " Pharmacokinetic studies in the dog demonstrated that the compound was well absorbed; the bioavailability was 36% of the dose of 1 mg/kg." | 1.27 | Metabolism of 14C-iodochlorhydroxyquin in the dog and the rat. ( Inaba, T; Jurima, M; Kalow, W, 1984) |
| "Clioquinol can increase the penetration of metallic cations through cellular membranes by forming lipophilic metal-chelates." | 1.27 | The aetiology of SMON may involve an interaction between clioquinol and environmental metals. ( Tjälve, H, 1984) |
| "8 g/kg) in shorter periods (19-47 days) and there was no difference between each group on the increasing dosage and on fixed dosage." | 1.25 | Neurotoxity of iodoxyquinoline: a further study on beagle dogs. ( Ikeda, H; Kuroda, S; Otsuki, S; Tateishi, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (88.12) | 18.7374 |
| 1990's | 4 (3.96) | 18.2507 |
| 2000's | 4 (3.96) | 29.6817 |
| 2010's | 3 (2.97) | 24.3611 |
| 2020's | 1 (0.99) | 2.80 |
| Authors | Studies |
|---|---|
| Kuru, S | 1 |
| Konishi, T | 1 |
| Hayashi, K | 1 |
| Sugiyama, H | 1 |
| Perez, DR | 1 |
| Sklar, LA | 1 |
| Chigaev, A | 1 |
| Katsuyama, M | 1 |
| Ibi, M | 1 |
| Matsumoto, M | 1 |
| Iwata, K | 1 |
| Ohshima, Y | 1 |
| Yabe-Nishimura, C | 1 |
| Konagaya, M | 1 |
| Matsuoka, Y | 1 |
| Nakae, K | 3 |
| Iwashita, H | 2 |
| Igata, A | 3 |
| Takasu, T | 3 |
| Hansson, O | 2 |
| Herxheimer, A | 1 |
| Soffer, M | 1 |
| Basdevant, A | 1 |
| Sarragoussi, JJ | 1 |
| Raison, J | 1 |
| Guy-Grand, B | 1 |
| Jurima, M | 1 |
| Kalow, W | 1 |
| Inaba, T | 1 |
| Tjälve, H | 1 |
| Okada, H | 1 |
| Aoki, K | 2 |
| Ohno, Y | 1 |
| Kitazawa, S | 1 |
| Ohtani, M | 2 |
| Egashira, Y | 1 |
| Matsuyama, H | 1 |
| Sturtevant, FM | 1 |
| Yolton, DP | 1 |
| Hanakago, R | 1 |
| Uono, M | 1 |
| Matsuki, Y | 1 |
| Yoshimura, S | 1 |
| Abe, M | 1 |
| Arbiser, JL | 1 |
| Kraeft, SK | 1 |
| van Leeuwen, R | 1 |
| Hurwitz, SJ | 1 |
| Selig, M | 1 |
| Dickersin, GR | 1 |
| Flint, A | 1 |
| Byers, HR | 1 |
| Chen, LB | 1 |
| Tabira, T | 1 |
| Mamoli, B | 1 |
| Thaler, A | 2 |
| Heilig, P | 2 |
| Siakos, G | 1 |
| Bernard, G | 1 |
| Griffith, RW | 1 |
| Otte, G | 2 |
| de Coster, W | 2 |
| Thiery, E | 2 |
| de Reuck, J | 2 |
| vander Eecken, H | 2 |
| de Pinto, O | 1 |
| Burley, D | 1 |
| Worden, AN | 1 |
| Heywood, R | 1 |
| Lee, JA | 1 |
| Shigematsu, I | 4 |
| Yanagawa, H | 2 |
| Asao, M | 1 |
| Fabiani, F | 1 |
| Sinibaldi, L | 1 |
| Meade, TW | 1 |
| Tateishi, J | 8 |
| Kono, R | 2 |
| Shiraki, H | 1 |
| Otsuki, S | 4 |
| Kuroda, S | 5 |
| Ikeda, H | 3 |
| Sobue, I | 1 |
| Yamamoto, S | 2 |
| Kusui, K | 1 |
| Tamura, Z | 3 |
| Toyokura, Y | 2 |
| Matsuoka, O | 1 |
| Wadia, NH | 2 |
| Degos, CF | 1 |
| Thomas-Lamotte, PJ | 1 |
| Hayakawa, K | 2 |
| Imanari, T | 2 |
| Aron, JJ | 1 |
| Lebuisson, DA | 1 |
| Guidi, M | 1 |
| Buchanan, DS | 1 |
| Mathew, R | 1 |
| Gupta, PS | 1 |
| Kasamaki, A | 1 |
| Furuya, K | 1 |
| Kanamitsu, M | 1 |
| Sonoda, K | 1 |
| Charasz, N | 1 |
| Vacherot, B | 1 |
| Dougados, M | 1 |
| Bousser, MG | 1 |
| Belaiche, J | 1 |
| Cattan, D | 1 |
| Vanĕcek, J | 1 |
| Fink, Z | 1 |
| Matsuda, M | 1 |
| Yanagisawa, N | 1 |
| Tsukada, N | 1 |
| Chevaleraud, JP | 1 |
| Hamard, H | 1 |
| Rose, FC | 1 |
| Katahira, K | 1 |
| Kobayshi, T | 1 |
| Higashida, T | 1 |
| Kamae, S | 1 |
| Nakajima, Y | 1 |
| Fujimoto, S | 1 |
| Bhasin, DK | 1 |
| Raina, R | 1 |
| Mehta, SK | 1 |
| Arora, MM | 1 |
| Wolffers, I | 1 |
| Shimada, Y | 1 |
| Tsuji, T | 1 |
| Steinitz, H | 1 |
| Osterman, PO | 1 |
| Selby, G | 2 |
| Spillane, JD | 1 |
| Billson, FH | 1 |
| Reich, J | 1 |
| Hopkins, IJ | 1 |
| Saito, A | 2 |
| Zeiller, P | 1 |
| Sensch, KH | 1 |
| Dahme, E | 1 |
| Aoyama, H | 1 |
| Oira, M | 1 |
| Ota, T | 1 |
| Yoshioka, S | 1 |
| Yoshida, T | 1 |
| Kean, BH | 1 |
| Roe, WP | 1 |
| Danis, P | 1 |
| Jensen, JP | 1 |
| Bryndum, B | 1 |
| Pedersen, KK | 1 |
| Christiansen, N | 1 |
| Nelson, E | 1 |
| Pannekoek, JH | 1 |
| Bron, HL | 1 |
| Korten, JJ | 1 |
| Pinckers, AJ | 1 |
| Majoor, CL | 1 |
| van Beeck, JA | 1 |
| Scholten, JB | 1 |
| Cambier, J | 1 |
| Masson, M | 1 |
| Berkman, N | 1 |
| Dairou, R | 1 |
| Jones, EL | 1 |
| Searle, CE | 1 |
| Smith, WT | 1 |
| Dimov, D | 1 |
| Grenier, B | 1 |
| Rolland, JC | 1 |
| Kiffer, A | 1 |
| Maupas, P | 1 |
| Oakley, GP | 1 |
| Yoshioka, M | 1 |
| Fukaya, J | 1 |
| Kusaka, J | 1 |
| Reich, JA | 1 |
| Billson, FA | 1 |
| Papuziński, M | 1 |
| Wilmowska-Pietruszyńska, A | 1 |
| Gendre, JP | 1 |
| Barbanel, C | 1 |
| Degos, JD | 1 |
| Le Quintrec, Y | 1 |
| Inoue, N | 1 |
| Kuroiwa, Y | 1 |
| Ikeda, M | 1 |
| Yasukouchi, T | 1 |
| Vitale, C | 1 |
| Feldman, JL | 1 |
| Hubault, A | 1 |
| Weisbecker, J | 1 |
| Bechetoille, A | 1 |
| de Sèze, S | 1 |
| McEwen, LM | 1 |
8 reviews available for clioquinol and Optic Neuritis
| Article | Year |
|---|---|
Clioquinol: To harm or heal.
Topics: Animals; Anti-Infective Agents; Asian People; ATP-Binding Cassette Transporters; Clioquinol; Cyclic | 2019 |
[SMON--a model of the iatrogenic disease].
Topics: Amebicides; Anti-Infective Agents, Local; Clioquinol; Humans; Iatrogenic Disease; Myelitis; Optic Ne | 2003 |
Subacute myelo-optico-neuropathy (SMON) in Japan. With special reference to the autopsy cases.
Topics: Adult; Aged; Animals; Autopsy; Clioquinol; Digestive System; Dogs; Female; Humans; Male; Middle Aged | 1982 |
[SMON and pharmacokinetics of chinoform with special reference to animal species difference].
Topics: Amebicides; Animals; Cats; Clioquinol; Dogs; Dose-Response Relationship, Drug; Humans; Lipid Peroxid | 1997 |
[Neurotoxicity of chinoform].
Topics: Acute Disease; Amebicides; Clioquinol; Humans; Myelitis; Optic Neuritis; Quality of Life; Severity o | 1999 |
Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis.
Topics: Abdomen; Clioquinol; Environmental Pollution; Epidemiologic Methods; Female; Humans; Japan; Male; My | 1975 |
[Neurotoxicity of chinoform].
Topics: Animals; Cats; Child; Clioquinol; Dogs; Guinea Pigs; Haplorhini; Humans; Lethal Dose 50; Mice; Myeli | 1976 |
Introductory review of subacute myeolo-optico-neuropathy (SMON) and its studies done by the SMON Research Commission.
Topics: Clioquinol; Humans; Japan; Male; Middle Aged; Myelitis; Optic Neuritis; Syndrome | 1975 |
93 other studies available for clioquinol and Optic Neuritis
| Article | Year |
|---|---|
[Fifity years after the identification of the cause of SMON].
Topics: Acute Disease; Administration, Oral; Animals; Clioquinol; Diagnosis, Differential; Humans; Japan; My | 2021 |
The Aggravation of Depression with Aging in Japanese Patients with Subacute Myelo-optico-neuropathy (SMON).
Topics: Aged; Aged, 80 and over; Aging; Asian People; Clioquinol; Depressive Disorder; Female; Humans; Male; | 2017 |
Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression.
Topics: Amebicides; Clioquinol; Gene Expression; Humans; Myelitis; Nerve Growth Factors; Neuroblastoma; Neur | 2014 |
[Analysis of SMON at 30 years after its outbreak ending: special reference to those patients with blindness].
Topics: Adult; Aged; Blindness; Clioquinol; Disease Outbreaks; Female; Follow-Up Studies; Humans; Japan; Mal | 2002 |
[Contribution of Japanese researchers to progress in the field of neurology in the last 100 years: SMON].
Topics: Clioquinol; History, 20th Century; Humans; Myelitis; Optic Neuritis; Syndrome | 2002 |
Idiosyncratic neurotoxicity: clioquinol and bismuth.
Topics: Austria; Bismuth; Brain Diseases; Clioquinol; Dose-Response Relationship, Drug; France; Humans; Japa | 1980 |
Neurotoxicity of oxyquinolines.
Topics: Abdomen; Clioquinol; Humans; Myelitis; Optic Neuritis; Pain; Syndrome | 1980 |
Oxyquinoline toxicity.
Topics: Clioquinol; Diverticulum; Drug Combinations; France; Humans; Hydroxyquinolines; Male; Middle Aged; M | 1983 |
Metabolism of 14C-iodochlorhydroxyquin in the dog and the rat.
Topics: Administration, Oral; Animals; Bile; Biological Availability; Clioquinol; Dogs; Female; Hydroxyquino | 1984 |
The aetiology of SMON may involve an interaction between clioquinol and environmental metals.
Topics: Clioquinol; Drug Interactions; Environmental Pollutants; Humans; Hydroxyquinolines; Japan; Metals; M | 1984 |
Effects of metal-containing drugs taken simultaneously with clioquinol upon clinical features of SMON.
Topics: Clioquinol; Drug Interactions; Female; Humans; Hydroxyquinolines; Male; Metals; Middle Aged; Motor A | 1984 |
Zinc deficiency, acrodermatitis enteropathica, optic atrophy, subacute myelo-optic neuropathy, and 5,7-dihalo-8-quinolinols.
Topics: Acrodermatitis; Clioquinol; Humans; Hydroxyquinolines; Myelitis; Optic Atrophy; Optic Neuritis; Oxyq | 1980 |
Nutritional effects of zinc on ocular and systemic physiology.
Topics: Clioquinol; Dithizone; Ethambutol; Eye Diseases; Humans; Intraocular Pressure; Iodoquinol; Isoniazid | 1981 |
Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan.
Topics: Acrodermatitis; Adult; Clioquinol; Global Health; Humans; Japan; Male; Myelitis; Optic Neuritis; Syn | 1981 |
Clioquinol-zinc chelate: a candidate causative agent of subacute myelo-optic neuropathy.
Topics: Chelating Agents; Clioquinol; Humans; Membrane Potentials; Mitochondria; Myelitis; Optic Neuritis; S | 1998 |
Clioquinol's return: cautions from Japan.
Topics: Alzheimer Disease; Animals; Clinical Trials, Phase II as Topic; Clioquinol; Humans; Japan; Mice; Mye | 2001 |
[Subacute myelo-optic-neuropathy (S.M.O.N.) following treatment with clioquinol (author's transl)].
Topics: Abdomen, Acute; Aged; Clioquinol; Colostomy; Electromyography; Extremities; Female; Humans; Male; My | 1975 |
Clioquinol.
Topics: Benzoates; Clioquinol; Drug Combinations; Drug Industry; Myelitis; Optic Neuritis; Oxyquinoline; Qui | 1977 |
Ultrastructural study of a muscle biopsy from a patient with subacute myelo-optic neuropathy.
Topics: Clioquinol; Humans; Inclusion Bodies; Male; Middle Aged; Muscles; Myelin Sheath; Myelitis; Neuromusc | 1977 |
Toxicity of oxyquinolines.
Topics: Clioquinol; Humans; Hydroxyquinolines; Myelitis; Optic Neuritis; Oxyquinoline; Syndrome | 1977 |
Clioquinol: time to act.
Topics: Abdomen; Clioquinol; Diarrhea; Humans; Myelitis; Optic Neuritis; Pain | 1977 |
Clioquinol toxicity.
Topics: Animals; Clioquinol; Dogs; Myelitis; Optic Neuritis; Syndrome | 1978 |
Data on clioquinol and S.M.O.N.
Topics: Clioquinol; Humans; Japan; Myelitis; Optic Neuritis; Syndrome | 1978 |
Data on clioquinol and S.M.O.N.
Topics: Clioquinol; Humans; Japan; Myelitis; Optic Neuritis; Syndrome | 1978 |
Clioquinol and S.M.O.N.: Reanalysis of original data.
Topics: Clioquinol; Drug Evaluation; Humans; Japan; Myelitis; Optic Neuritis; Population Surveillance; Syndr | 1979 |
S.M.O.N. in Italy.
Topics: Adult; Clioquinol; Diagnosis, Differential; Female; Humans; Italy; Myelitis; Optic Neuritis; Syndrom | 1977 |
The neuropathology of subacute myelo-optico-neuropathy, "SMON", in the humans: --with special reference to the quinoform intoxication.
Topics: Adolescent; Adult; Aged; Brain; Brain Stem; Cerebellum; Child; Clioquinol; Cranial Nerves; Diencepha | 1975 |
Experimental reproduction of SMON in animals by prolonged administration of clioquinol: clinico-pathological findings.
Topics: Acute Disease; Animals; Cats; Chronic Disease; Clioquinol; Dogs; Haplorhini; Kidney; Liver; Male; Mi | 1975 |
Neurotoxity of iodoxyquinoline: a further study on beagle dogs.
Topics: Administration, Oral; Animals; Clioquinol; Disease Models, Animal; Dogs; Intestines; Kidney; Liver; | 1975 |
Prognosis of SMON patients.
Topics: Adult; Age Factors; Aged; Clioquinol; Female; Humans; Male; Middle Aged; Myelitis; Optic Neuritis; P | 1975 |
Epidemiological approach to SMON (subacute myelo-optico-neuropathy).
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Clioquinol; Female; Follow-Up Studies | 1975 |
Subacute myelo-optico-neuropathy (SMON) and clioquinol: -A response to doubts about clioquinol causation theory-.
Topics: Clioquinol; Dose-Response Relationship, Drug; Epidemiologic Methods; Humans; Japan; Myelitis; Optic | 1975 |
Outline of the joint SMON investigation by the clinical section.
Topics: Clioquinol; Follow-Up Studies; Humans; Japan; Myelitis; Optic Neuritis; Syndrome | 1975 |
Clinical chemistry of clioquinol.
Topics: Adult; Aged; Animals; Chemical Phenomena; Chemistry; Clioquinol; Female; Humans; Male; Mice; Middle | 1975 |
Experimental studies utilizing radionuclide-labelled clioquinol as tracer in vivo.
Topics: Animals; Autoradiography; Biotransformation; Clioquinol; Digestive System; Humans; Liver; Myelitis; | 1975 |
Clinical features of SMON.
Topics: Adult; Clioquinol; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Myelitis; Optic Neuri | 1975 |
Subacute myelo-optic neuropathy. A toxic or a viral etiology?
Topics: Clioquinol; Humans; Male; Middle Aged; Myelitis; Optic Neuritis; Syndrome | 1976 |
Some observations on SMON from Bombay.
Topics: Adult; Aged; Child; Clioquinol; Female; Humans; India; Male; Middle Aged; Myelitis; Optic Neuritis; | 1977 |
[A iatrogenic disease... subacute myelo-optico-neuropathy].
Topics: Clioquinol; Humans; Myelitis; Optic Neuritis | 1977 |
Relationship between neurological symptoms and concentrations of clioquinol in serum and nervous systems of beagle dogs.
Topics: Animals; Central Nervous System; Clioquinol; Dogs; Female; Myelitis; Optic Neuritis; Syndrome | 1977 |
[Further study on the neurotoxicity of clioquinol in beagle dogs (author's transl)].
Topics: Animals; Clioquinol; Dogs; Female; Male; Myelitis; Optic Neuritis | 1975 |
[Optic neuritis caused by clioquinol derivatives in children (apropos of 2 cases)].
Topics: Child, Preschool; Clioquinol; Diarrhea; Female; Humans; Intestinal Absorption; Optic Neuritis | 1977 |
[SMON syndrome].
Topics: Clioquinol; Humans; Myelitis; Optic Neuritis; Syndrome | 1977 |
Iatrogenic causes of neurologic disorders: part 1. Affect, convulsions, and encephalopathies.
Topics: Affective Symptoms; Aged; Antiparkinson Agents; Brain Diseases; Clioquinol; Cognition Disorders; Hum | 1978 |
Sub-acute myelo-optico neuropathy (a case report).
Topics: Adult; Clioquinol; Diagnosis, Differential; Female; Humans; Myelitis; Optic Neuritis; Syndrome | 1978 |
Demonstration of antibody activity to clioquinol in sera of experimental rabbits and patients with subacute myelo-optico-neuropathy.
Topics: Adult; Aged; Animals; Antibodies; Antibody Specificity; Clioquinol; Hemagglutination Inhibition Test | 1978 |
SMON and other socially induced diseases in Japan.
Topics: Clioquinol; Humans; Japan; Life Style; Myelitis; Optic Neuritis; Social Isolation; Social Security; | 1978 |
[Subacute myelo-optic-neuropathy during treatment with chloro-iodo-hydroxyquinoleine (author's transl)].
Topics: Aged; Clioquinol; Female; Humans; Myelitis; Optic Neuritis | 1979 |
[Subacute myelo-optic neuritis].
Topics: Clioquinol; Humans; Myelitis; Optic Neuritis; Syndrome | 1979 |
[Subsets of peripheral blood lymphocytes and ageing in patients with SMON].
Topics: Aged; Aging; Clioquinol; Humans; Leukocyte Count; Lymphocyte Subsets; Middle Aged; Myelitis; Nervous | 1991 |
[Optic neuropathies].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Central Nervous System Agents; | 1985 |
Ethnic differences in drugs and xenobiotics. Clioquinol.
Topics: Adult; Child, Preschool; Clioquinol; Female; Humans; Hydroxyquinolines; Japan; Male; Middle Aged; My | 1986 |
Chinese acupuncture treatment for SMON patients.
Topics: Acupuncture Therapy; Adolescent; Adult; Aged; Clioquinol; Female; Humans; Hydroxyquinolines; Male; M | 1986 |
Assessment of neurotoxicity of clioquinol (Enterovioform) by visual evoked potentials. A preliminary communication.
Topics: Adult; Clioquinol; Diarrhea; Evoked Potentials, Visual; Female; Humans; Hydroxyquinolines; Male; Mid | 1985 |
[The history of quinolines].
Topics: Clioquinol; History, 20th Century; Humans; Hydroxyquinolines; Japan; Myelitis; Optic Neuritis; Quino | 1985 |
Halogenated oxyquinoline derivatives and neurological syndromes.
Topics: Abdomen; Administration, Oral; Adult; Aged; Clioquinol; Feces; Female; Fluorescent Antibody Techniqu | 1971 |
Myelopathy after clioquinol treatment.
Topics: Abdomen; Adult; Clioquinol; Humans; Male; Myelitis; Nervous System Diseases; Neurologic Manifestatio | 1971 |
Subacute myelo-optic neuropathy in Australia.
Topics: Abdomen; Aged; Australia; Clioquinol; Diarrhea; Female; Humans; Male; Middle Aged; Myelitis; Neurolo | 1972 |
S.M.O.N.
Topics: Abdomen; Adult; Clioquinol; Diarrhea; Female; Humans; Myelitis; Optic Neuritis; Pain; Paresthesia | 1972 |
Visual failure in a patient with ulcerative colitis treated by clioquinol.
Topics: Adolescent; Child; Clioquinol; Colitis, Ulcerative; Female; Humans; Optic Atrophy; Optic Nerve; Opti | 1972 |
Neurotoxicity of clioquinol in laboratory animals.
Topics: Abdomen; Administration, Oral; Animals; Cats; Clioquinol; Dogs; Myelitis; Optic Neuritis; Pain | 1972 |
S.M.O.N.: different effects of dichloroquine and iodochloroquine in cats and mice.
Topics: Abdomen; Animals; Cats; Chlorine; Clioquinol; Mice; Myelitis; Optic Neuritis; Pain; Quinolines | 1973 |
Relation between subacute myelo-optic neuropathy (S.M.O.N.) and clioquinol: nationwide survey.
Topics: Abdomen; Adolescent; Adult; Aged; Child; Clioquinol; Dose-Response Relationship, Drug; Female; Human | 1973 |
More on S.M.O.N.
Topics: Clioquinol; Humans; Hydroxyquinolines; Optic Neuritis; Oxyquinoline; Spinal Cord Diseases | 1971 |
Myelo-optic neuropathy induced by clioquinol in animals.
Topics: Animals; Cats; Clioquinol; Disease Models, Animal; Dogs; Hydroxyquinolines; Macaca; Optic Neuritis; | 1971 |
[Epidemiological studies on subacute myelo-optico neuropathy (SMON) in the town of Yubara, Japan. 3].
Topics: Abdomen; Clioquinol; Female; Humans; Male; Myelitis; Optic Neuritis; Pain | 1970 |
Subacute myelo-optic neuropathy: a probable case in the United States.
Topics: Adult; Clioquinol; Diarrhea; Gait; Giardiasis; Humans; Intestinal Diseases, Parasitic; Male; Neuromu | 1972 |
Going abroad.
Topics: Abdomen; Clioquinol; Diarrhea; Humans; Myelitis; Optic Neuritis; Pain | 1972 |
[Optic neuritis and clioquinol].
Topics: Aged; Clioquinol; Enterocolitis, Pseudomembranous; Humans; Male; Optic Neuritis; Oxyphenonium; Phena | 1971 |
[Subacute myelo-optico-neuropathy].
Topics: Aged; Clioquinol; Diarrhea; Female; Humans; Optic Neuritis; Polyneuropathies | 1972 |
[Acute and chronic clioquinol intoxication].
Topics: Acute Disease; Adult; Chronic Disease; Clioquinol; Female; Humans; Optic Neuritis | 1972 |
Subacute myelo-optico-neuropathy (SMON).
Topics: Abdomen; Clioquinol; Humans; Japan; Myelitis; Neurologic Manifestations; Optic Neuritis; Pain | 1972 |
[Neurotoxic symptoms following clioquinol (Enterovioform)].
Topics: Abdomen; Animals; Clioquinol; Humans; Intestinal Diseases; Myelitis; Optic Neuritis; Pain | 1972 |
[Subacute myelo-optico-neuropathy following use of large amounts of iodochlorhydroxyquinoline (Enterovioform)].
Topics: Abdomen; Adult; Aged; Clioquinol; Diarrhea; Female; Humans; Myelitis; Optic Neuritis; Pain | 1972 |
[Polyneuropathy following long-term use of clioquinol (Enterovioform)].
Topics: Abdomen; Aged; Clioquinol; Diarrhea; Humans; Male; Myelitis; Optic Neuritis; Pain | 1972 |
[Sensory neuropathy and optic neuritis after prolonged absorption of chloroidoquinone].
Topics: Aged; Clioquinol; Extremities; Female; Humans; Neuritis; Neurologic Manifestations; Optic Neuritis; | 1972 |
Peripheral neuropathy in rats fed with clioquinol.
Topics: Abdomen; Animals; Anti-Infective Agents, Local; Clioquinol; Humans; Myelitis; Optic Neuritis; Pain; | 1972 |
[Subacute myelo-optic neuropathy--toxic reaction or viral disease?].
Topics: Abdomen; Aged; Child; Clioquinol; Female; Humans; Myelitis; Optic Neuritis; Pain; Virus Diseases | 1972 |
[Subacute myeloradiculoneuritis and chloroiodoxyquinolein: poisoning or virus disease?].
Topics: Abdomen; Acute Disease; Aged; Child; Clioquinol; Diarrhea, Infantile; Drug Combinations; Enterovirus | 1973 |
Subacute myelo-optico-neuropathy (SMON)--neurotoxicity of clioquinols.
Topics: Abdomen; Aged; Clioquinol; Diarrhea; Enteritis; Female; Humans; Intestinal Absorption; Male; Middle | 1973 |
The neurotoxicity of the halogenated hydroxyquinolines. A commentary.
Topics: Abdomen; Anti-Infective Agents; Central Nervous System; Chlorquinaldol; Clioquinol; Disease Outbreak | 1973 |
Identification of green pigment and analysis of clioquinol in specimens from patients with subacute myelo-optico-neuropathy.
Topics: Adult; Aged; Carbon Radioisotopes; Chromatography, Gas; Clioquinol; Female; Humans; Iron Chelating A | 1973 |
Toxic optic neuritis. Clioquinol ingestion in a child.
Topics: Child; Clioquinol; Female; Humans; Optic Neuritis; Scotoma | 1973 |
Is there SMON in India?
Topics: Abdomen; Adult; Clioquinol; Female; Humans; India; Male; Middle Aged; Myelitis; Optic Neuritis; Pain | 1973 |
Comparative study of neurotoxicity of clioquinol, ethambutol, isoniazid and chloramphenicol in dogs.
Topics: Abdomen; Administration, Oral; Animals; Axons; Chloramphenicol; Clioquinol; Dogs; Ethambutol; Isonia | 1974 |
Warning on diiodohydroxyquin.
Topics: Abdomen; Acrodermatitis; Adult; Age Factors; Amebiasis; Child, Preschool; Chronic Disease; Clioquino | 1974 |
[Subacute myelo-optico neuropathy (author's transl)].
Topics: Abdomen; Aged; Clioquinol; Color Perception; Colostomy; Dose-Response Relationship, Drug; Humans; My | 1974 |
[Neurological complications in the course of treatment of acrodermatitis enteropathica with oxyquinoline derivatives].
Topics: Abdomen; Acrodermatitis; Child; Child, Preschool; Clioquinol; Female; Humans; Infant; Myelitis; Opti | 1974 |
[Experimental studies of influence of hepatic insufficiency on pathogenesis of S.M.O.N. (subacute myelo-optico neuropathy) caused by chinoform administration in dogs (author's transl)].
Topics: Administration, Oral; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1974 |
[Serious sensory-motor neuropathy. A case of renal failure following clioquinol absorption].
Topics: Abdomen; Autopsy; Clioquinol; Demyelinating Diseases; Drug Tolerance; Electromyography; Humans; Kidn | 1974 |
[Analysis of the effects of chinoform on subacute myelo-optico-neuropathy (SMON)--application of linear regression analysis by logistic transformation].
Topics: Abdomen; Adolescent; Clioquinol; Dose-Response Relationship, Drug; Humans; Myelitis; Optic Neuritis; | 1974 |
[Subacute neuromyelitis with optic neuritis following chloroiodoquine. A new case].
Topics: Clioquinol; Colitis; Constipation; Female; Humans; Middle Aged; Multiple Sclerosis; Neuromyelitis Op | 1974 |
Neuropathy after clioquinol.
Topics: Anti-Infective Agents, Local; Clioquinol; Female; Humans; Male; Optic Neuritis; Paralysis; Periphera | 1971 |