clioquinol has been researched along with Optic Nerve Diseases in 13 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Optic Nerve Diseases: Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, dysphagia has attracted attention as a complication of SMON." | 1.48 | Tongue strength in patients with subacute myelo-optico-neuropathy. ( Ando, Y; Honda, S; Kimura, E; Konagaya, M; Nakama, T; Ueda, M; Yamashita, S, 2018) |
| "The prevalence of major depressive disorder in SMON patients was estimated by structured interview and using Beck's depression inventory (BDI) questionnaires." | 1.35 | Depression in patients with subacute myelo-optico-neuropathy (SMON). ( Fujimura, H; Funakawa, I; Hayashi, K; Hayashi, M; Kaido, M; Konishi, T; Ueno, S; Yoshida, S, 2008) |
| "Clioquinol is a hydroxyquinoline antibiotic that has been associated with severe side-effects in the CNS." | 1.31 | Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol. ( Ekblom, J; Gottfries, CG; Oreland, L; Xilinas, M; Yassin, MS, 2000) |
| " The onset of all manifestations (except toxic encephalopathy) was usually subacute, with subsequent partial recovery." | 1.26 | Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan. ( Baumgartner, G; Gawel, MJ; Kaeser, HE; Pallis, CA; Rose, FC; Schaumburg, HH; Thomas, PK; Wadia, NH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamashita, S | 2 |
| Nakama, T | 1 |
| Ueda, M | 1 |
| Honda, S | 1 |
| Kimura, E | 2 |
| Konagaya, M | 3 |
| Ando, Y | 1 |
| Konishi, T | 3 |
| Schaumburg, H | 1 |
| Herskovitz, S | 1 |
| Mao, X | 1 |
| Li, X | 1 |
| Sprangers, R | 1 |
| Wang, X | 1 |
| Venugopal, A | 1 |
| Wood, T | 1 |
| Zhang, Y | 1 |
| Kuntz, DA | 1 |
| Coe, E | 1 |
| Trudel, S | 1 |
| Rose, D | 1 |
| Batey, RA | 1 |
| Kay, LE | 1 |
| Schimmer, AD | 1 |
| Hayashi, K | 1 |
| Hayashi, M | 1 |
| Ueno, S | 1 |
| Yoshida, S | 1 |
| Fujimura, H | 1 |
| Funakawa, I | 1 |
| Kaido, M | 1 |
| Hirano, T | 1 |
| Hirai, T | 1 |
| Uchida, Y | 1 |
| Maeda, Y | 1 |
| Uchino, M | 1 |
| Kuru, S | 1 |
| Konagaya, Y | 1 |
| Matsumoto, A | 1 |
| Takase, S | 1 |
| Mizutani, T | 1 |
| Sobue, G | 1 |
| Hayabara, T | 1 |
| Iwashita, H | 1 |
| Ujihira, T | 1 |
| Miyata, K | 1 |
| Matsuoka, Y | 1 |
| Yamanaka, Y | 1 |
| Asahina, M | 1 |
| Akaogi, Y | 1 |
| Koyama, Y | 1 |
| Hattori, T | 1 |
| Yassin, MS | 1 |
| Ekblom, J | 1 |
| Xilinas, M | 1 |
| Gottfries, CG | 1 |
| Oreland, L | 1 |
| Tateishi, J | 1 |
| Baumgartner, G | 1 |
| Gawel, MJ | 1 |
| Kaeser, HE | 1 |
| Pallis, CA | 1 |
| Rose, FC | 1 |
| Schaumburg, HH | 1 |
| Thomas, PK | 1 |
| Wadia, NH | 1 |
| Chevaleraud, JP | 1 |
| Hamard, H | 1 |
1 review available for clioquinol and Optic Nerve Diseases
| Article | Year |
|---|---|
Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals.
Topics: Animals; Brain Injuries; Clioquinol; Diagnosis, Differential; Disease Models, Animal; Humans; Japan; | 2000 |
12 other studies available for clioquinol and Optic Nerve Diseases
| Article | Year |
|---|---|
Tongue strength in patients with subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Clioquinol; Deglutition Disorders; Female; H | 2018 |
Physical Disabilities Related to the Depressive Mental States of Japanese Patients with Subacute Myelo-optico-neuropathy.
Topics: Age Factors; Aged; Aged, 80 and over; Clioquinol; Depressive Disorder; Disability Evaluation; Female | 2018 |
Copper deficiency myeloneuropathy: a clue to clioquinol-induced subacute myelo-optic neuropathy?
Topics: Animals; Chelating Agents; Clioquinol; Copper; Humans; Nerve Fibers, Myelinated; Optic Nerve; Optic | 2008 |
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.
Topics: Animals; Antineoplastic Agents; Archaeal Proteins; Asian People; Cell Line, Tumor; Clioquinol; Coppe | 2009 |
Depression in patients with subacute myelo-optico-neuropathy (SMON).
Topics: Aged; Aged, 80 and over; Clioquinol; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; | 2008 |
Cervical MRI of subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anthelmintics; Chelating Agents; Clioquinol; Copper; Female; Humans; Magnet | 2011 |
[Evaluation of neurological symptoms related to hip fracture in a 29-year longitudinal study of subacute myelo-optic-neuropathy (SMON)].
Topics: Aged; Clioquinol; Female; Femoral Neck Fractures; Humans; Longitudinal Studies; Male; Middle Aged; M | 2010 |
Clinical analysis of longstanding subacute myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban.
Topics: Aged; Aged, 80 and over; Amebicides; Autonomic Nervous System Diseases; Blindness; Clioquinol; Cohor | 2004 |
Diminished skin vasodilator response to local heating in patients with long-standingsubacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Autonomic Dysreflexia; Autonomic Nervous System Dise | 2007 |
Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol.
Topics: Amebicides; Animals; Brain; Clioquinol; Male; Metals; Mice; Mice, Inbred Strains; Optic Nerve Diseas | 2000 |
Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Child, Preschool; Clioquinol; Dose-Response Relation | 1979 |
[Optic neuropathies].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Central Nervous System Agents; | 1985 |